WO2010092589A3 - Process for preparation of amorphous carvedilol phosphate - Google Patents

Process for preparation of amorphous carvedilol phosphate Download PDF

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Publication number
WO2010092589A3
WO2010092589A3 PCT/IN2009/000301 IN2009000301W WO2010092589A3 WO 2010092589 A3 WO2010092589 A3 WO 2010092589A3 IN 2009000301 W IN2009000301 W IN 2009000301W WO 2010092589 A3 WO2010092589 A3 WO 2010092589A3
Authority
WO
WIPO (PCT)
Prior art keywords
carvedilol phosphate
preparation
amorphous carvedilol
phosphate
amorphous
Prior art date
Application number
PCT/IN2009/000301
Other languages
French (fr)
Other versions
WO2010092589A2 (en
Inventor
Koundinya Jitendra
Kumar Rajiv
Rampal Ashok
Kumar Arvindbhai Patel Dharmesh
Original Assignee
Alkem Laboratories Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkem Laboratories Ltd. filed Critical Alkem Laboratories Ltd.
Publication of WO2010092589A2 publication Critical patent/WO2010092589A2/en
Publication of WO2010092589A3 publication Critical patent/WO2010092589A3/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/88Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Abstract

The present invention relates to a process for the preparation of amorphous carvedilol phosphate comprising; adding carvedilol base or carvedilol phosphate to a solvent consisting of water miscible cyclic ether(s) or aliphatic nitrile(s) or a mixture thereof and optionally adding water; optionally, adding orthophosphoric acid or its diluted solution to the preceeding; and spray drying the solution thus obtained to afford amorphous carvedilol phosphate.
PCT/IN2009/000301 2008-05-26 2009-05-26 Process for preparation of amorphous carvedilol phosphate WO2010092589A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1100MU2008 2008-05-26
IN1100/MUM/2008 2008-05-26

Publications (2)

Publication Number Publication Date
WO2010092589A2 WO2010092589A2 (en) 2010-08-19
WO2010092589A3 true WO2010092589A3 (en) 2011-04-14

Family

ID=42562134

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000301 WO2010092589A2 (en) 2008-05-26 2009-05-26 Process for preparation of amorphous carvedilol phosphate

Country Status (1)

Country Link
WO (1) WO2010092589A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4503067A (en) * 1978-04-13 1985-03-05 Boehringer Mannheim Gmbh Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions
WO2007144900A2 (en) * 2006-06-14 2007-12-21 Matrix Laboratories Limited Carvedilol phosphate sesquihydrate
WO2008002683A2 (en) * 2006-06-28 2008-01-03 Teva Pharmaceutical Industries Ltd. Polymorphous forms of carvedilol phosphate
WO2008084494A1 (en) * 2007-01-08 2008-07-17 Matrix Laboratories Limited Novel polymorphic forms of carvedilol dihydrogen phosphate and process for preparing the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4503067A (en) * 1978-04-13 1985-03-05 Boehringer Mannheim Gmbh Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions
WO2007144900A2 (en) * 2006-06-14 2007-12-21 Matrix Laboratories Limited Carvedilol phosphate sesquihydrate
WO2008002683A2 (en) * 2006-06-28 2008-01-03 Teva Pharmaceutical Industries Ltd. Polymorphous forms of carvedilol phosphate
WO2008084494A1 (en) * 2007-01-08 2008-07-17 Matrix Laboratories Limited Novel polymorphic forms of carvedilol dihydrogen phosphate and process for preparing the same

Also Published As

Publication number Publication date
WO2010092589A2 (en) 2010-08-19

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