WO2010066034A8 - Narcotic drug formulations with decreased abuse potential - Google Patents

Narcotic drug formulations with decreased abuse potential Download PDF

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Publication number
WO2010066034A8
WO2010066034A8 PCT/CA2009/001778 CA2009001778W WO2010066034A8 WO 2010066034 A8 WO2010066034 A8 WO 2010066034A8 CA 2009001778 W CA2009001778 W CA 2009001778W WO 2010066034 A8 WO2010066034 A8 WO 2010066034A8
Authority
WO
WIPO (PCT)
Prior art keywords
abuse potential
drug formulations
narcotic drug
formulations
decreased abuse
Prior art date
Application number
PCT/CA2009/001778
Other languages
French (fr)
Other versions
WO2010066034A1 (en
Inventor
Robert Vinson
Patrick Gosselin
Aimesther Ojito Betancourt
Original Assignee
Paladin Labs Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paladin Labs Inc. filed Critical Paladin Labs Inc.
Priority to CA2690824A priority Critical patent/CA2690824C/en
Priority to EP09831343A priority patent/EP2379111B1/en
Priority to US13/133,141 priority patent/US8460640B2/en
Priority to ES09831343T priority patent/ES2414856T3/en
Priority to PL09831343T priority patent/PL2379111T3/en
Priority to MX2011006173A priority patent/MX2011006173A/en
Priority to BRPI0917608A priority patent/BRPI0917608B8/en
Publication of WO2010066034A1 publication Critical patent/WO2010066034A1/en
Publication of WO2010066034A8 publication Critical patent/WO2010066034A8/en
Priority to ZA2011/04337A priority patent/ZA201104337B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Abstract

The present application relates to novel narcotic formulations having a decreased injection abuse potential In a representative embodiment, the formulation comprises methadone hydrochloride (6-dimethylamino-4,4-diphenylheptan-3-one, a synthetic opiod), meglumine, cellulose, lactose, and magnesium stearate The application further illustrates methods for making the contemplated formulations.
PCT/CA2009/001778 2008-12-12 2009-12-14 Methadone formulation WO2010066034A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA2690824A CA2690824C (en) 2008-12-12 2009-12-14 Methadone formulation
EP09831343A EP2379111B1 (en) 2008-12-12 2009-12-14 Narcotic drug formulations with decreased abuse potential
US13/133,141 US8460640B2 (en) 2008-12-12 2009-12-14 Narcotic drug formulations with decreased abuse potential
ES09831343T ES2414856T3 (en) 2008-12-12 2009-12-14 Narcotic drug formulations with decreased addiction potential
PL09831343T PL2379111T3 (en) 2008-12-12 2009-12-14 Narcotic drug formulations with decreased abuse potential
MX2011006173A MX2011006173A (en) 2008-12-12 2009-12-14 Narcotic drug formulations with decreased abuse potential.
BRPI0917608A BRPI0917608B8 (en) 2008-12-12 2009-12-14 oral drug formulation for the reduction of potential abuse, process for manufacturing a drug formulation and its use
ZA2011/04337A ZA201104337B (en) 2008-12-12 2011-06-10 Narcotic drug formulations with decreased abuse potential

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12211708P 2008-12-12 2008-12-12
US61/122,117 2008-12-12

Publications (2)

Publication Number Publication Date
WO2010066034A1 WO2010066034A1 (en) 2010-06-17
WO2010066034A8 true WO2010066034A8 (en) 2010-08-19

Family

ID=42242269

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2009/001778 WO2010066034A1 (en) 2008-12-12 2009-12-14 Methadone formulation

Country Status (8)

Country Link
US (1) US8460640B2 (en)
EP (1) EP2379111B1 (en)
BR (1) BRPI0917608B8 (en)
ES (1) ES2414856T3 (en)
MX (1) MX2011006173A (en)
PL (1) PL2379111T3 (en)
WO (1) WO2010066034A1 (en)
ZA (1) ZA201104337B (en)

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Also Published As

Publication number Publication date
PL2379111T3 (en) 2013-08-30
WO2010066034A1 (en) 2010-06-17
US20110237615A1 (en) 2011-09-29
ZA201104337B (en) 2012-03-28
EP2379111B1 (en) 2013-03-20
EP2379111A1 (en) 2011-10-26
BRPI0917608B8 (en) 2021-05-25
MX2011006173A (en) 2011-09-01
ES2414856T3 (en) 2013-07-23
BRPI0917608B1 (en) 2021-04-13
EP2379111A4 (en) 2011-11-16
US8460640B2 (en) 2013-06-11

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