WO2009115906A3 - A process for the preparation of carvedilol involving halohydrin derivative - Google Patents

A process for the preparation of carvedilol involving halohydrin derivative Download PDF

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Publication number
WO2009115906A3
WO2009115906A3 PCT/IB2009/000556 IB2009000556W WO2009115906A3 WO 2009115906 A3 WO2009115906 A3 WO 2009115906A3 IB 2009000556 W IB2009000556 W IB 2009000556W WO 2009115906 A3 WO2009115906 A3 WO 2009115906A3
Authority
WO
WIPO (PCT)
Prior art keywords
carvedilol
involving
preparation
halohydrin derivative
halohydrin
Prior art date
Application number
PCT/IB2009/000556
Other languages
French (fr)
Other versions
WO2009115906A2 (en
Inventor
Indravadan Ambalal Modi
Sanjay Muktawat
Sanjay Laxamanbhai Patel
Ramasubbu Chandrasekaran
Ravi Ponnaiah
Bakulesh Mafatlal Khamar
Original Assignee
Cadila Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Pharmaceuticals Ltd. filed Critical Cadila Pharmaceuticals Ltd.
Publication of WO2009115906A2 publication Critical patent/WO2009115906A2/en
Publication of WO2009115906A3 publication Critical patent/WO2009115906A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

The present invention relates to a cost effective and industrially viable process for th preparation of Carvedilol involving halohydrin derivative
PCT/IB2009/000556 2008-03-19 2009-03-19 An improved process for preparation of carvedilol involving halohydrin derivative WO2009115906A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN560MU2008 2008-03-19
IN560/MUM/2008 2008-03-19

Publications (2)

Publication Number Publication Date
WO2009115906A2 WO2009115906A2 (en) 2009-09-24
WO2009115906A3 true WO2009115906A3 (en) 2009-11-12

Family

ID=40998885

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/000556 WO2009115906A2 (en) 2008-03-19 2009-03-19 An improved process for preparation of carvedilol involving halohydrin derivative

Country Status (1)

Country Link
WO (1) WO2009115906A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102190613B (en) * 2010-03-14 2014-06-25 浙江华海药业股份有限公司 Method for preparing carvedilol

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4503067A (en) * 1978-04-13 1985-03-05 Boehringer Mannheim Gmbh Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions
EP0918055A1 (en) * 1997-11-24 1999-05-26 Egis Gyogyszergyar Rt. Process and intermediates for preparing 1-[9'H-carbazol-4'-yloxy]-3-[ 2''-(2'''- methoxy -phenoxy)-ethyl)-amino]-propan-2-ol[carvedilol]

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4503067A (en) * 1978-04-13 1985-03-05 Boehringer Mannheim Gmbh Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions
EP0918055A1 (en) * 1997-11-24 1999-05-26 Egis Gyogyszergyar Rt. Process and intermediates for preparing 1-[9'H-carbazol-4'-yloxy]-3-[ 2''-(2'''- methoxy -phenoxy)-ethyl)-amino]-propan-2-ol[carvedilol]

Also Published As

Publication number Publication date
WO2009115906A2 (en) 2009-09-24

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