WO2008027442A3 - Abuse deterrent oral pharmaceutical formulations of opioid agonists and method of use - Google Patents

Abuse deterrent oral pharmaceutical formulations of opioid agonists and method of use Download PDF

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Publication number
WO2008027442A3
WO2008027442A3 PCT/US2007/019015 US2007019015W WO2008027442A3 WO 2008027442 A3 WO2008027442 A3 WO 2008027442A3 US 2007019015 W US2007019015 W US 2007019015W WO 2008027442 A3 WO2008027442 A3 WO 2008027442A3
Authority
WO
WIPO (PCT)
Prior art keywords
opioid agonists
pharmaceutical formulations
oral pharmaceutical
abuse deterrent
agonists
Prior art date
Application number
PCT/US2007/019015
Other languages
French (fr)
Other versions
WO2008027442A2 (en
Inventor
Najib Babul
Original Assignee
Theraquest Biosciences Llc
Najib Babul
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theraquest Biosciences Llc, Najib Babul filed Critical Theraquest Biosciences Llc
Publication of WO2008027442A2 publication Critical patent/WO2008027442A2/en
Publication of WO2008027442A3 publication Critical patent/WO2008027442A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Abstract

The present invention is directed to pharmaceutical compositions of opioid agonists and the use thereof for preventing or minimizing the risk of abuse and/or toxicity due to opioid agonists and any co-abused cannabinoid agonists or alcohol from either intentional or unintentional tampering. The present invention is also directed at methods of preventing or minimizing the risk of abuse and/or toxicity due to opioid agonists and any co-abused cannabinoid agonists or alcohol from either intentional or unintentional tampering.
PCT/US2007/019015 2006-08-30 2007-08-30 Abuse deterrent oral pharmaceutical formulations of opioid agonists and method of use WO2008027442A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84097006P 2006-08-30 2006-08-30
US60/840,970 2006-08-30
US84899406P 2006-10-04 2006-10-04
US60/848,994 2006-10-04

Publications (2)

Publication Number Publication Date
WO2008027442A2 WO2008027442A2 (en) 2008-03-06
WO2008027442A3 true WO2008027442A3 (en) 2008-10-16

Family

ID=39136569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/019015 WO2008027442A2 (en) 2006-08-30 2007-08-30 Abuse deterrent oral pharmaceutical formulations of opioid agonists and method of use

Country Status (1)

Country Link
WO (1) WO2008027442A2 (en)

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ES2360102T3 (en) 2003-03-26 2011-05-31 Egalet A/S SYSTEM FOR CONTROLLED RELEASE OF MORPHINE.
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US20090246256A1 (en) * 2008-03-27 2009-10-01 Al-Ghananeem Abeer M Compositions and Methods for Transmucosal Delivery of Lofexidine
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CN102210764B (en) * 2011-05-30 2013-04-17 陕西师范大学 Application of sweet almond oil in preparing medicament for treating myocardial ischemia reperfusion injury
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EP2877161A1 (en) 2012-07-06 2015-06-03 Egalet Ltd. Abuse deterrent pharmaceutical compositions for controlled release
CA2880282C (en) 2012-07-27 2020-09-01 Redhill Biopharma Ltd. Formulations and methods of manufacturing formulations for use in colonic evacuation
EP2890367A4 (en) * 2012-08-29 2016-03-30 Salix Pharmaceuticals Inc Laxative compositions and methods for treating constipation and related gastrointestinal diseases and conditions
US9101636B2 (en) 2012-11-30 2015-08-11 Acura Pharmaceuticals, Inc. Methods and compositions for self-regulated release of active pharmaceutical ingredient
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WO2015071248A1 (en) 2013-11-15 2015-05-21 Synthon B.V. Abuse-proofed extended release pharmaceutical composition comprising tapentadol
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10183919B2 (en) 2014-03-12 2019-01-22 The Trustees Of Columbia University In The City Of New York Class of mu-opioid receptor agonists
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AU2015336065A1 (en) * 2014-10-20 2017-05-04 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
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KR20180012771A (en) * 2015-05-13 2018-02-06 4피-파마 Stimulant abuse inhibiting composition
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CA3010636A1 (en) 2016-06-29 2018-01-04 CannScience Innovations Inc. Decarboxylated cannabis resins, uses thereof and methods of making same
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CN112759670B (en) * 2020-12-17 2022-03-15 中国石油大学(华东) Mussel bionic functionalized hydrophilic polymer and hydrophilic polymer network modified super-hydrophilic net membrane as well as preparation method and application thereof
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US20030143269A1 (en) * 2000-02-08 2003-07-31 Benjamin Oshlack Tamper-resistant oral opioid agonist formulations
US20070185145A1 (en) * 2006-02-03 2007-08-09 Royds Robert B Pharmaceutical composition containing a central opioid agonist, a central opioid antagonist, and a peripheral opioid antagonist, and method for making the same

Patent Citations (6)

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US20030143269A1 (en) * 2000-02-08 2003-07-31 Benjamin Oshlack Tamper-resistant oral opioid agonist formulations
US20030004177A1 (en) * 2001-05-11 2003-01-02 Endo Pharmaceuticals, Inc. Abuse-resistant opioid dosage form
US20030003113A1 (en) * 2001-06-29 2003-01-02 Lewandowski Leon J. Individualized addiction cessation therapy
US20030073714A1 (en) * 2001-08-06 2003-04-17 Christopher Breder Opioid agonist formulations with releasable and sequestered antagonist
US20070185145A1 (en) * 2006-02-03 2007-08-09 Royds Robert B Pharmaceutical composition containing a central opioid agonist, a central opioid antagonist, and a peripheral opioid antagonist, and method for making the same

Also Published As

Publication number Publication date
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