WO2005021504A3 - New crystalline forms of carvedilol - Google Patents

New crystalline forms of carvedilol Download PDF

Info

Publication number
WO2005021504A3
WO2005021504A3 PCT/SI2004/000029 SI2004000029W WO2005021504A3 WO 2005021504 A3 WO2005021504 A3 WO 2005021504A3 SI 2004000029 W SI2004000029 W SI 2004000029W WO 2005021504 A3 WO2005021504 A3 WO 2005021504A3
Authority
WO
WIPO (PCT)
Prior art keywords
carvedilol
new crystalline
crystalline forms
processes
relates
Prior art date
Application number
PCT/SI2004/000029
Other languages
French (fr)
Other versions
WO2005021504A2 (en
Inventor
Rok Zupet
Marija Grcman
Matej Smrkolj
Original Assignee
Krka Tovarna Zdravil D D Novo
Rok Zupet
Marija Grcman
Matej Smrkolj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka Tovarna Zdravil D D Novo, Rok Zupet, Marija Grcman, Matej Smrkolj filed Critical Krka Tovarna Zdravil D D Novo
Priority to EP04775682A priority Critical patent/EP1660451A2/en
Publication of WO2005021504A2 publication Critical patent/WO2005021504A2/en
Publication of WO2005021504A3 publication Critical patent/WO2005021504A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Abstract

The present invention relates to new crystalline carvedilol forms VII and IX and to processes for the preparation thereof. Particularly, this invention relates to processes of the isolation of carvedilol, using ethyl acetate as a solvent.
PCT/SI2004/000029 2003-09-02 2004-09-01 New crystalline forms of carvedilol WO2005021504A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04775682A EP1660451A2 (en) 2003-09-02 2004-09-01 New crystalline forms of carvedilol

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200300218A SI21616A (en) 2003-09-02 2003-09-02 New crystal forms of carvedilol
SIP-200300218 2003-09-02

Publications (2)

Publication Number Publication Date
WO2005021504A2 WO2005021504A2 (en) 2005-03-10
WO2005021504A3 true WO2005021504A3 (en) 2005-06-02

Family

ID=34271325

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SI2004/000029 WO2005021504A2 (en) 2003-09-02 2004-09-01 New crystalline forms of carvedilol

Country Status (3)

Country Link
EP (1) EP1660451A2 (en)
SI (1) SI21616A (en)
WO (1) WO2005021504A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0301802A3 (en) 2000-06-28 2009-04-28 Teva Pharma Process for producing carvedilol, crystalline carvedilol, process for producing it and pharmaceutical composition containing it
KR20040077872A (en) 2002-01-15 2004-09-07 테바 파마슈티컬 인더스트리즈 리미티드 Crystalline solids of carvedilol and processes for their preparation
KR20070088507A (en) * 2005-06-09 2007-08-29 테바 파마슈티컬 인더스트리즈 리미티드 Crystalline forms of carvedilol and processes for their preparation
WO2007043938A1 (en) * 2005-10-07 2007-04-19 Astrazeneca Ab NOVEL CRYSTALLINE FORM OF 3,5-DIBROMO-N- [ (2S) -2- (-4- FLUOROPHENYL) -4- (3-MORPHOLIN-4-YLAZTIDIN-l-YL) BUTYL] -N METHYLBENZAMIDE, MODIFICATION B
US8022094B2 (en) 2006-06-28 2011-09-20 Teva Pharmaceutical Industries Ltd. Carvedilol phosphate

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999005105A1 (en) * 1997-07-22 1999-02-04 Roche Diagnostics Gmbh Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it
WO2002000216A1 (en) * 2000-06-28 2002-01-03 Teva Pharmaceutical Industries Ltd. Carvedilol
WO2003005970A2 (en) * 2001-07-13 2003-01-23 Smithkline Beecham Corporation Carvedilol polymorph
WO2003029214A1 (en) * 2001-09-28 2003-04-10 F. Hoffmann-La Roche Ag Pseudopolymorphic forms of carvedilol
WO2003059807A2 (en) * 2002-01-15 2003-07-24 Teva Pharmaceutical Industries Ltd. Crystalline solids of carvedilol and processes for their preparation
WO2004041783A1 (en) * 2002-11-08 2004-05-21 Zentiva, A.S. Process for preparation of carvedilol
WO2004041252A1 (en) * 2002-11-08 2004-05-21 Egalet A/S Controlled release carvedilol compositions
WO2004113296A1 (en) * 2003-06-20 2004-12-29 Sun Pharmaceutical Industries Limited A process for preparation of 1-[9h-carbazol-4-yloxy]- 3-[{2-(2-(-(methoxy)phenoxy)-ethyl}-amino]-propan-2-ol

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999005105A1 (en) * 1997-07-22 1999-02-04 Roche Diagnostics Gmbh Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it
WO2002000216A1 (en) * 2000-06-28 2002-01-03 Teva Pharmaceutical Industries Ltd. Carvedilol
WO2003005970A2 (en) * 2001-07-13 2003-01-23 Smithkline Beecham Corporation Carvedilol polymorph
WO2003029214A1 (en) * 2001-09-28 2003-04-10 F. Hoffmann-La Roche Ag Pseudopolymorphic forms of carvedilol
WO2003059807A2 (en) * 2002-01-15 2003-07-24 Teva Pharmaceutical Industries Ltd. Crystalline solids of carvedilol and processes for their preparation
WO2004041783A1 (en) * 2002-11-08 2004-05-21 Zentiva, A.S. Process for preparation of carvedilol
WO2004041252A1 (en) * 2002-11-08 2004-05-21 Egalet A/S Controlled release carvedilol compositions
WO2004113296A1 (en) * 2003-06-20 2004-12-29 Sun Pharmaceutical Industries Limited A process for preparation of 1-[9h-carbazol-4-yloxy]- 3-[{2-(2-(-(methoxy)phenoxy)-ethyl}-amino]-propan-2-ol

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VENKATESH, GOPI M. ET AL: "Detection of low levels of the amorphous phase in crystalline pharmaceutical materials by thermally stimulated current spectrometry", PHARMACEUTICAL RESEARCH , 18(1), 98-103 CODEN: PHREEB; ISSN: 0724-8741, 2001, XP002316351 *

Also Published As

Publication number Publication date
WO2005021504A2 (en) 2005-03-10
SI21616A (en) 2005-04-30
EP1660451A2 (en) 2006-05-31

Similar Documents

Publication Publication Date Title
WO2006012379A3 (en) Processes for preparation of crystalline mycophenolate sodium
WO2006128150A3 (en) Crystalline solid forms of tigecycline and methods of preparing same
WO2008092954A8 (en) Polymorphic forms of a macrocyclic inhibitor of hcv
WO2009036281A3 (en) Bortezomib and process for producing same
WO2006069363A3 (en) Crystalline forms of (r)-8-chloro-1-methyl- 2,3,4,5-tetrahydro-1h-3-benzazepine hydrochloride
WO2004113292A3 (en) Fluvastatin sodium crystal forms, processes for preparing them, compositions containing them and methods of using them
TW200606149A (en) Crystalline polymorph of bazedoxifene acetate
WO2003070725A3 (en) Process for preparing indolinone derivatives
WO2005105769A3 (en) Mycophenolate mofetil impurity
UA86055C2 (en) Crystalline polymorph of bazedoxifene acetate
WO2005070893A3 (en) Azadecalin glucocorticoid receptor modulators
WO2007024961A3 (en) Bazedoxifene acetate formulations and manufacturing process thereof
WO2005062897A3 (en) Polymorphs of ezetimibe and processes for the preparation thereof
WO2007127292A3 (en) Tigeycline crystalline forms and processes for preparation thereof
WO2006023889A3 (en) A method for preparing irbesartan and intermediates thereof
WO2005085236A3 (en) Caspase inhibitors and uses thereof
AU2003282383A1 (en) A process for the preparation of high purity escitalopram
IL183449A0 (en) Process for the preparation of carvedilol and its enantiomers
WO2006029253A3 (en) A valacyclovir impurity, process for the preparation of valacyclovir impurity and use as a reference standard
WO2007098273A3 (en) Novel crystalline forms of armodafinil and preparation thereof
WO2007026373A3 (en) Process for preparing rivastigmine
WO2005021504A3 (en) New crystalline forms of carvedilol
UA85703C2 (en) Crystalline polymorph of bazedoxifene acetate
WO2005061493A3 (en) Polymorphic form b2 of ziprasidone base
WO2007080470A3 (en) A method for the purification of levetiracetam

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2004775682

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2004775682

Country of ref document: EP