WO2004047839A8 - High concentration formulations of opioids and opioid derivatives - Google Patents

High concentration formulations of opioids and opioid derivatives

Info

Publication number
WO2004047839A8
WO2004047839A8 PCT/US2003/038174 US0338174W WO2004047839A8 WO 2004047839 A8 WO2004047839 A8 WO 2004047839A8 US 0338174 W US0338174 W US 0338174W WO 2004047839 A8 WO2004047839 A8 WO 2004047839A8
Authority
WO
WIPO (PCT)
Prior art keywords
formulations
fentanyl
opioid
opioids
high concentration
Prior art date
Application number
PCT/US2003/038174
Other languages
French (fr)
Other versions
WO2004047839A1 (en
Inventor
Tai Wah Chan
Original Assignee
Durect Corp
Tai Wah Chan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Durect Corp, Tai Wah Chan filed Critical Durect Corp
Priority to AU2003297608A priority Critical patent/AU2003297608A1/en
Priority to EP03812057A priority patent/EP1585519A4/en
Priority to CN2003801085558A priority patent/CN1735413B/en
Priority to JP2004555827A priority patent/JP4510637B2/en
Priority to CA002507356A priority patent/CA2507356A1/en
Publication of WO2004047839A1 publication Critical patent/WO2004047839A1/en
Publication of WO2004047839A8 publication Critical patent/WO2004047839A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention provides opioid formulations suitable for long-term delivery to a subject. The formulation of the invention comprises an opioid or opioid derivative (e.g., morphine, hydromorphone, fentanyl or a fentanyl congener), and an aqueous solvent comprising a low molecular weight carboxylic acid (e.g., C2-4, C2-7). The invention thus provides for formulations comprising morphine, hydromorphone, fentanyl or fentanyl congeners in concentrations significantly in excess of conventional aqueous formulations, e.g., on the order about 2-fold to about 10,000-fold greater than conventional formulations, e.g., currently commercially available formulations.
PCT/US2003/038174 2002-11-25 2003-11-25 High concentration formulations of opioids and opioid derivatives WO2004047839A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2003297608A AU2003297608A1 (en) 2002-11-25 2003-11-25 High concentration formulations of opioids and opioid derivatives
EP03812057A EP1585519A4 (en) 2002-11-25 2003-11-25 High concentration formulations of opioids and opioid derivatives
CN2003801085558A CN1735413B (en) 2002-11-25 2003-11-25 High concentration formulations of opioids and opioid derivatives
JP2004555827A JP4510637B2 (en) 2002-11-25 2003-11-25 High concentration formulations of opioids and opioid derivatives
CA002507356A CA2507356A1 (en) 2002-11-25 2003-11-25 High concentration formulations of opioids and opioid derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/305,252 US20040102476A1 (en) 2002-11-25 2002-11-25 High concentration formulations of opioids and opioid derivatives
US10/305,252 2002-11-25

Publications (2)

Publication Number Publication Date
WO2004047839A1 WO2004047839A1 (en) 2004-06-10
WO2004047839A8 true WO2004047839A8 (en) 2004-08-19

Family

ID=32325387

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/038174 WO2004047839A1 (en) 2002-11-25 2003-11-25 High concentration formulations of opioids and opioid derivatives

Country Status (7)

Country Link
US (2) US20040102476A1 (en)
EP (1) EP1585519A4 (en)
JP (2) JP4510637B2 (en)
CN (1) CN1735413B (en)
AU (1) AU2003297608A1 (en)
CA (1) CA2507356A1 (en)
WO (1) WO2004047839A1 (en)

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US20040234602A1 (en) 2001-09-21 2004-11-25 Gina Fischer Polymer release system
US20040102476A1 (en) * 2002-11-25 2004-05-27 Chan Tai Wah High concentration formulations of opioids and opioid derivatives
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EP2822535A1 (en) * 2012-03-07 2015-01-14 Mallinckrodt LLC Improved stability of hydromorphone hydrochloride solutions
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US9650338B1 (en) 2016-07-29 2017-05-16 VDM Biochemicals, Inc. Opioid antagonist compounds and methods of making and using

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Also Published As

Publication number Publication date
AU2003297608A1 (en) 2004-06-18
CN1735413B (en) 2010-05-12
EP1585519A1 (en) 2005-10-19
CN1735413A (en) 2006-02-15
EP1585519A4 (en) 2009-09-23
JP4510637B2 (en) 2010-07-28
US20110136847A1 (en) 2011-06-09
CA2507356A1 (en) 2004-06-10
JP2010159270A (en) 2010-07-22
JP2006509772A (en) 2006-03-23
US20040102476A1 (en) 2004-05-27
WO2004047839A1 (en) 2004-06-10

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