WO2003084504A3 - Matrix for sustained, invariant and independent release of active compounds - Google Patents

Matrix for sustained, invariant and independent release of active compounds Download PDF

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Publication number
WO2003084504A3
WO2003084504A3 PCT/EP2003/003541 EP0303541W WO03084504A3 WO 2003084504 A3 WO2003084504 A3 WO 2003084504A3 EP 0303541 W EP0303541 W EP 0303541W WO 03084504 A3 WO03084504 A3 WO 03084504A3
Authority
WO
WIPO (PCT)
Prior art keywords
matrix
invariant
sustained
active compounds
independent release
Prior art date
Application number
PCT/EP2003/003541
Other languages
French (fr)
Other versions
WO2003084504A2 (en
Inventor
Bianca Broegmann
Silke Muehlau
Christof Spitzley
Original Assignee
Euro Celtique Sa
Bianca Broegmann
Silke Muehlau
Christof Spitzley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=28676052&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2003084504(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE10215131A external-priority patent/DE10215131A1/en
Priority claimed from DE10215067A external-priority patent/DE10215067A1/en
Priority to MXPA04009714A priority Critical patent/MXPA04009714A/en
Priority to EP03720425.2A priority patent/EP1492506B2/en
Priority to JP2003581744A priority patent/JP4620355B2/en
Priority to CA002478523A priority patent/CA2478523A1/en
Priority to NZ535286A priority patent/NZ535286A/en
Priority to BR0309004-3A priority patent/BR0309004A/en
Priority to DK03720425.2T priority patent/DK1492506T4/en
Priority to DE60325567T priority patent/DE60325567D1/en
Priority to ES03720425.2T priority patent/ES2320748T5/en
Priority to APAP/P/2004/003138A priority patent/AP2397A/en
Priority to SI200331518T priority patent/SI1492506T1/en
Application filed by Euro Celtique Sa, Bianca Broegmann, Silke Muehlau, Christof Spitzley filed Critical Euro Celtique Sa
Priority to US10/510,673 priority patent/US20050245483A1/en
Priority to AU2003224041A priority patent/AU2003224041B2/en
Priority to KR1020047015830A priority patent/KR100717591B1/en
Publication of WO2003084504A2 publication Critical patent/WO2003084504A2/en
Publication of WO2003084504A3 publication Critical patent/WO2003084504A3/en
Priority to IL16398904A priority patent/IL163989A0/en
Priority to ZA2004/07317A priority patent/ZA200407317B/en
Priority to TNP2004000193A priority patent/TNSN04193A1/en
Priority to HK05105024.4A priority patent/HK1072366A1/en
Priority to US13/348,617 priority patent/US8846090B2/en
Priority to US14/058,108 priority patent/US8846091B2/en
Priority to US14/489,452 priority patent/US9655855B2/en
Priority to US15/582,119 priority patent/US20170231978A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The invention concerns a storage stable pharmaceutical formulation comprising preferably two active compounds in a non-swellable diffusion matrix, whereby the compounds are released from the matrix in a sustained, invariant and, if several compounds are present, independent manner and the matrix is determined with respect to its substantial release characteristics by ethylcellulose and at least one fatty alcohol. The invention also concerns methods for producing such pharmaceutical formulations.
PCT/EP2003/003541 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds WO2003084504A2 (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
KR1020047015830A KR100717591B1 (en) 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds
US10/510,673 US20050245483A1 (en) 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds
APAP/P/2004/003138A AP2397A (en) 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds.
AU2003224041A AU2003224041B2 (en) 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds
JP2003581744A JP4620355B2 (en) 2002-04-05 2003-04-04 Matrix for sustained, constant and independent release of active compounds
CA002478523A CA2478523A1 (en) 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds
NZ535286A NZ535286A (en) 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds
BR0309004-3A BR0309004A (en) 2002-04-05 2003-04-04 Matrix for gradual, invariant and independent release of active compounds
DK03720425.2T DK1492506T4 (en) 2002-04-05 2003-04-04 Matrix for depot, invariant and independent release of active compounds
DE60325567T DE60325567D1 (en) 2002-04-05 2003-04-04 MATRIX FOR THE MODIFIED RELEASE OF ACTIVE SUBSTANCES
ES03720425.2T ES2320748T5 (en) 2002-04-05 2003-04-04 Matrix for sustained, invariable and independent release of active compounds
EP03720425.2A EP1492506B2 (en) 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds
SI200331518T SI1492506T1 (en) 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds
MXPA04009714A MXPA04009714A (en) 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds.
IL16398904A IL163989A0 (en) 2002-04-05 2004-09-09 Matrix for sustained, invariant and independent release of active compounds
ZA2004/07317A ZA200407317B (en) 2002-04-05 2004-09-13 Matrix for substained invariant and independent release of active compounds
TNP2004000193A TNSN04193A1 (en) 2002-04-05 2004-10-04 MATRIX RELATING TO SUSTAINED, INVARIANT AND INDEPENDENT DELIVERY OF ACTIVE COMPOUNDS
HK05105024.4A HK1072366A1 (en) 2002-04-05 2005-06-15 Matrix for sustained, invariant and independent release of active compounds
US13/348,617 US8846090B2 (en) 2002-04-05 2012-01-11 Matrix for sustained, invariant and independent release of active compounds
US14/058,108 US8846091B2 (en) 2002-04-05 2013-10-18 Matrix for sustained, invariant and independent release of active compounds
US14/489,452 US9655855B2 (en) 2002-04-05 2014-09-17 Matrix for sustained, invariant and independent release of active compounds
US15/582,119 US20170231978A1 (en) 2002-04-05 2017-04-28 Matrix for sustained, invariant and independent release of active compounds

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10215131.8 2002-04-05
DE10215131A DE10215131A1 (en) 2002-04-05 2002-04-05 Stable pharmaceutical preparation useful for the treatment of pain, especially severe pain, without causing side-effects comprises oxycodone and naxolone in retarded release formulation
DE10215067.2 2002-04-05
DE10215067A DE10215067A1 (en) 2002-04-05 2002-04-05 Stable pharmaceutical preparation useful for the treatment of pain, especially severe pain, without causing side-effects comprises oxycodone and naxolone in retarded release formulation

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US10/510,673 A-371-Of-International US20050245483A1 (en) 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds
US10510673 A-371-Of-International 2003-04-04
US13/348,617 Continuation US8846090B2 (en) 2002-04-05 2012-01-11 Matrix for sustained, invariant and independent release of active compounds

Publications (2)

Publication Number Publication Date
WO2003084504A2 WO2003084504A2 (en) 2003-10-16
WO2003084504A3 true WO2003084504A3 (en) 2004-03-11

Family

ID=28676052

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2003/003541 WO2003084504A2 (en) 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds
PCT/EP2003/003540 WO2003084520A2 (en) 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/003540 WO2003084520A2 (en) 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone

Country Status (33)

Country Link
US (11) US20050245483A1 (en)
EP (17) EP2425824B1 (en)
JP (5) JP4620355B2 (en)
KR (3) KR100784341B1 (en)
CN (4) CN102813654A (en)
AP (2) AP2043A (en)
AR (3) AR039378A1 (en)
AT (1) ATE418967T2 (en)
AU (2) AU2003224041B2 (en)
BR (2) BRPI0309544B8 (en)
CA (3) CA2478515C (en)
CO (2) CO5611100A2 (en)
CY (5) CY1108914T1 (en)
DE (6) DE20308437U1 (en)
DK (6) DK2425825T3 (en)
ES (7) ES2546010T3 (en)
FI (1) FI7846U1 (en)
GE (3) GEP20084485B (en)
HK (5) HK1072367A1 (en)
HU (4) HUE032529T2 (en)
IL (5) IL163990A0 (en)
LT (3) LT2425824T (en)
MA (2) MA27249A1 (en)
MX (2) MXPA04009713A (en)
NZ (1) NZ535286A (en)
PH (1) PH12018000176A1 (en)
PT (5) PT2425825T (en)
RU (3) RU2297225C2 (en)
SI (5) SI2425821T1 (en)
TN (1) TNSN04192A1 (en)
TW (3) TWI337077B (en)
WO (2) WO2003084504A2 (en)
ZA (2) ZA200407267B (en)

Cited By (5)

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US8846090B2 (en) 2002-04-05 2014-09-30 Euro-Celtique S.A. Matrix for sustained, invariant and independent release of active compounds
US8932630B1 (en) 1997-12-22 2015-01-13 Purdue Pharma L.P Opioid agonist/antagonist combinations
US8936808B1 (en) 1997-12-22 2015-01-20 Purdue Pharma L.P. Opioid agonist/opioid antagonist/acetaminophen combinations
US8969369B2 (en) 2001-05-11 2015-03-03 Purdue Pharma L.P. Abuse-resistant controlled-release opioid dosage form
US9271940B2 (en) 2009-03-10 2016-03-01 Purdue Pharma L.P. Immediate release pharmaceutical compositions comprising oxycodone and naloxone

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EP2295043A1 (en) 1999-10-29 2011-03-16 Euro-Celtique S.A. Controlled release hydrocodone formulations
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
JP2003522144A (en) 2000-02-08 2003-07-22 ユーロ−セルティーク，エス．エイ． Controlled release compositions comprising opioid agonists and antagonists
AUPQ899700A0 (en) 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
CN101317825A (en) 2000-10-30 2008-12-10 欧罗赛铁克股份有限公司 Controlled release hydrocodone formulations
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
SI1416842T1 (en) 2001-07-18 2009-06-30 Euro Celtique Sa Pharmaceutical combinations of oxycodone and naloxone
ES2326794T3 (en) 2001-08-06 2009-10-20 Euro-Celtique S.A. FORMULATIONS OF OPIOID AGONISTS WITH LIBERABLE AND SEQUESTED ANTAGONISTS.
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
PA8578501A1 (en) 2002-07-25 2005-02-04 Pharmacia Corp DOSAGE FORM ONCE A DAY OF PRAMIPEXOL
MY135852A (en) 2003-04-21 2008-07-31 Euro Celtique Sa Pharmaceutical products
DE102005005446A1 (en) 2005-02-04 2006-08-10 Grünenthal GmbH Break-resistant dosage forms with sustained release
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10336400A1 (en) 2003-08-06 2005-03-24 Grünenthal GmbH Anti-abuse dosage form
DE10361596A1 (en) 2003-12-24 2005-09-29 Grünenthal GmbH Process for producing an anti-abuse dosage form
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US20060194826A1 (en) * 2003-09-25 2006-08-31 Euro-Celtique S.A. Pharmaceutical combinations of hydrocodone and naltrexone
GB0501638D0 (en) * 2005-01-28 2005-03-02 Euro Celtique Sa Particulates
TWI350762B (en) * 2004-02-12 2011-10-21 Euro Celtique Sa Particulates
GB0403098D0 (en) 2004-02-12 2004-03-17 Euro Celtique Sa Extrusion
EP1604667A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
EP1604666A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
DE102004032049A1 (en) 2004-07-01 2006-01-19 Grünenthal GmbH Anti-abuse, oral dosage form
CN101849920A (en) * 2004-08-13 2010-10-06 贝林格尔·英格海姆国际有限公司 The prolongation that comprises pramipexole or its officinal salt discharges pellet formulation, Its Preparation Method And Use
RS51527B2 (en) 2004-08-13 2018-02-28 Boehringer Ingelheim Int Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
CA2594373A1 (en) * 2005-01-28 2006-08-03 Euro-Celtique S.A. Alcohol resistant dosage forms
DE102005005449A1 (en) 2005-02-04 2006-08-10 Grünenthal GmbH Process for producing an anti-abuse dosage form
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