WO1998020862A1 - Sofortige benetzbarkeit aufweisende(r) wasserlöslicher film oder wasserlösliche schicht zur oralen applikation - Google Patents

Sofortige benetzbarkeit aufweisende(r) wasserlöslicher film oder wasserlösliche schicht zur oralen applikation Download PDF

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Publication number
WO1998020862A1
WO1998020862A1 PCT/EP1997/005820 EP9705820W WO9820862A1 WO 1998020862 A1 WO1998020862 A1 WO 1998020862A1 EP 9705820 W EP9705820 W EP 9705820W WO 9820862 A1 WO9820862 A1 WO 9820862A1
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WO
WIPO (PCT)
Prior art keywords
film
preparation according
water
water soluble
cellulose
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PCT/EP1997/005820
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English (en)
French (fr)
Inventor
Horst Georg Zerbe
Anthony J. Serino
Jian-Hwa Guo
Original Assignee
Lts Lohmann Therapie-Systeme Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to HU9904207A priority Critical patent/HU228464B1/hu
Priority to IL12981997A priority patent/IL129819A0/xx
Application filed by Lts Lohmann Therapie-Systeme Gmbh filed Critical Lts Lohmann Therapie-Systeme Gmbh
Priority to HU0500666A priority patent/HU230022B1/hu
Priority to AT97911237T priority patent/ATE247954T1/de
Priority to SK5041-2005A priority patent/SK285999B6/sk
Priority to DK03014213T priority patent/DK1362584T3/da
Priority to EP97911237A priority patent/EP0936905B1/de
Priority to CA002265651A priority patent/CA2265651C/en
Priority to DK97911237T priority patent/DK0936905T3/da
Priority to SI9730590T priority patent/SI0936905T1/xx
Priority to AU48682/97A priority patent/AU739698B2/en
Priority to CZ0164799A priority patent/CZ297354B6/cs
Priority to JP52208898A priority patent/JP4063331B2/ja
Priority to DE59710670T priority patent/DE59710670D1/de
Priority to PL97333677A priority patent/PL190376B1/pl
Priority to SK622-99A priority patent/SK285100B6/sk
Publication of WO1998020862A1 publication Critical patent/WO1998020862A1/de
Priority to NO19991921A priority patent/NO325073B1/no
Priority to HK00101167A priority patent/HK1035316A1/xx
Priority to NO20053307A priority patent/NO20053307D0/no

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/90—Block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention discloses a preparation which contains pharmaceutical active substances and / or breath-refreshing active substances for use in the oral cavity.
  • the carrier comprises water-soluble polymers in combination with certain ingredients and has a therapeutic and / or cosmetic effect.
  • the film is spread and dried using existing coating technologies and has immediate wettability, followed by rapid dissolution / decomposition when applied in the oral cavity.
  • a water-insoluble film can be added to make the surface non-adhesive.
  • WO 91/06270 by the same inventor discloses a three-layer film for prolonged release of an active ingredient in the oral cavity.
  • US 4,876,092 discloses a sheet-like, adhesive preparation comprising an adhesive layer which contains certain water-soluble and water-insoluble polymers and a water-insoluble carrier which adheres to the oral mucosa and thereby releases an active ingredient into the oral cavity. All of the aforesaid devices are not completely water-soluble and remain in the oral cavity even after the therapeutic goal has been achieved and cause some discomfort to the patient in the mouth, mainly caused by the backing layer which leaves an insoluble residue in the mouth.
  • CA 1 263 312 discloses the use of polyolefins such as polyethylene, polypropylene, polyester, PVC and nonwovens as soft carrier materials. Nevertheless, these leave a considerable amount of residues of the water-insoluble carrier film in the patient and therefore still cause an uncomfortable feeling.
  • An obvious solution to overcome this problem was to develop films that stick to the mucous membrane and which completely disintegrate or dissolve in the saliva.
  • Fuchs and Hilmann (DE 24 49 865.5) produced homogeneous, water-soluble films for buccal delivery of hormones. They proposed the use of water-soluble cellulose derivatives such as hydroxyethyl cellulose, hydroxypropyl cellulose or methyl hydroxypropyl cellulose as film formers.
  • the two patents DE 36 30 603 and EP 0 219 762 disclose the use of swellable polymers such as gelatin or corn starch as film formers, which according to Ap- slowly dissolve in the oral cavity, releasing an active ingredient that is contained in the film.
  • the same polymers can also be used to make films for dental care, as described in EP 0 452 446. But these preparations also cause an uncomfortable feeling in the mouth, particularly caused by their initial rigidity and delayed softening. This results in a need for a composition for use in the oral cavity that takes into account the need for a feeling of well-being in the mouth.
  • the present invention discloses methods and preparations by which an uncomfortable feeling can be avoided by providing an instantly wettable film / layer for application to the oral mucosa and by which a tear strength in the free film is achieved which is problem-free Coating, processing and packaging of a consumer-friendly product enables.
  • the present invention relates to a film or layer which dissolves in a film and which adheres to the oral cavity and thereby releases a pharmaceutical or cosmetic active substance, the film / layer being water-soluble polymers, one or more polyalcohols and one or more pharmaceutically or contains cosmetic active ingredients.
  • the formulation can optionally contain a combination of certain plasticizers or surface-active substances, colorants, sweeteners, flavoring agents, taste improvers or other corrigents, as are usually used to modify the taste of formulations intended for application in the oral cavity.
  • the resulting film is characterized by immediate wettability, which allows the film to soften immediately after application to the mucosal tissue, which means that the patient has a longer the unpleasant feeling in the mouth is prevented, as well as a tear resistance suitable for normal coating, cutting, slicing and packaging operations.
  • the mucoadhesive film of the present invention contains as essential components a water-soluble polymer or a combination of water-soluble polymers, one or more plasticizers or surface-active substances, one or more polyalcohols and a pharmaceutical or cosmetic active ingredient.
  • the polymers used for the mucoadhesive film include hydrophilic and / or water dispersible polymers.
  • Preferred polymers are water-soluble cellulose derivatives. Hydroxypropylmethyl cellulose, hydroxyethyl cellulose and hydroxypropyl cellulose, alone or mixed, are particularly preferred.
  • polyvinyl pyrrolidone polyvinyl pyrrolidone
  • carboxymethyl cellulose polyvinyl alcohol, sodium alginate
  • polyethylene glycol polyethylene glycol
  • natural gums such as xanthan resin, tragacanth, guar resin, acacia resin, gum arabic
  • water-dispersible polyacrylates such as polyacrylic acid, Methyl methacrylate copolymer, carboxyvinyl copolymers.
  • concentration of the water-soluble polymer in the finished film can be between 20 and 75% by weight. A preferred concentration is between 50 and 75% by weight.
  • the surfactants used for the mucoadhesive film can be one or more nonionic surfactants.
  • the first component can be a polyethoxysorbitan fatty acid ester or an ⁇ -hydro- ⁇ -hydroxypoly (ethoxy) poly (propoxy) poly (ethoxy) block copolymer
  • the second component can be a polye - can be thoxyalkyl ether or a polyethoxy castor oil derivative.
  • the HLB value of the polyethoxysorbitan fatty acid esters should preferably be between 10 and 20, a range between 13 and 17 being particularly preferred.
  • the ⁇ -hydro- ⁇ -hydroxypoly (ethoxy) poly (propoxy) poly (ethoxy) block copolymer should contain at least 35 propoxy units, preferably at least 50 propoxy units.
  • the polyethoxyalkyl ether should have an HLB value between 10 and 20, preferably not less than 15.
  • the polyethoxy castor oil derivative should have an HLB value between 14 and 16.
  • the ratio between the first and the second component of a binary surface-active mixture should be kept between 1:10 and 1: 1, preferably between 1: 5 and 1: 3.
  • the total concentration of surface-active substances in the finished film depends on the properties of the other ingredients, but should normally be between 0.1 and 5% by weight.
  • the polyalcohol is required to achieve the desired level of softness in the film.
  • examples of polyalcohols include glycerin, polyethylene glycol, propylene glycol, glycerol monoesters with fatty acids, or other pharmaceutically used polyalcohols.
  • concentration of polyalcohol in the dry mass of the film is usually 0.1 to 5% by weight.
  • the film is particularly well suited for delivering a wide range of pharmaceutically active ingredients through a patient's mucous membrane, particularly through the buccal mucosa.
  • Therapeutic agents that have absorption problems due to limited solubility, breakdown in the gastrointestinal tract or have extensive metabolism are particularly well suited.
  • the therapeutic agents that can be used include: hypnotics, sedatives, antiepileptics, weckamines, psychoneurotropics, neuromuscle blockers, antispasmodics, antihistamines, antiallergics, cardiotonica, antiarrhythmics, diuretics, hypotensives, vasopressors, antitussives Expectorantia, thyroid hormones, sex hormones, antidiabetics, antitumor agents, antibiotics as well as chemotherapeutics and narcotics.
  • the amount of active ingredient to be stored in the film depends on its type and is usually between 0.01 and 20% by weight, but it can be higher if necessary to achieve the desired effect.
  • Cosmetic active ingredients include breath fresheners such as menthol, other flavors, aromas or fragrances as are usually used for oral hygiene, and / or active ingredients for dental care and / or oral hygiene, for example quaternary ammonium bases.
  • breath fresheners such as menthol
  • other flavors, aromas or fragrances as are usually used for oral hygiene
  • active ingredients for dental care and / or oral hygiene, for example quaternary ammonium bases.
  • flavor enhancers such as tartaric acid, citric acid, vanillin or the like.
  • Dyes that are optionally added to the film must be safe in terms of toxicity and should be approved for use in cosmetics by the responsible authorities.
  • the mucoadhesive film according to the invention can be produced as follows:
  • the polyalcohol, surfactants, plasticizers, and other possible ingredients other than the water-soluble or water-dispersible polymer (s) are dissolved with a sufficient amount of a compatible solvent.
  • a compatible solvent include water, alcohols or mixtures thereof.
  • suitable materials include non-siliconized polyethylene terephthalate films, non-siliconized kraft paper, polyethylene-impregnated kraft paper or non-siliconized polyethylene film.
  • the solution can be applied to the carrier material using any conventional device.
  • a particularly preferred application technique relates to a roller doctor coating machine.
  • the thickness of the resulting film layer depends on the concentration of solids in the coating solution and on the gap width of the coating machine and can vary between 5 and 200 ⁇ m.
  • the film is dried in a hot air bath using a drying oven, drying tunnel, vacuum dryer or other suitable drying devices which do not adversely affect the action of the active ingredient (s) or flavorings. In order to reliably avoid an uncomfortable feeling in the mouth, the film thickness should not exceed 70 ⁇ m. For better ease of use, the film can be cut into pieces of suitable size and shape and packaged.
  • Example 1 The invention is illustrated by the following examples.
  • Example 1 Example 1 :
  • hydroxypropylmethyl cellulose are slowly added to the solution with stirring until a clear and homogeneous solution is formed.
  • the resulting solution is then allowed to cool to room temperature and spread onto a suitable substrate, such as non-siliconized polyethylene coated kraft paper, using a conventional coating / drying device.
  • Coating gap and web speed must be controlled so that a dry film thickness between 20 and 50 ⁇ m is achieved.
  • the drying temperature depends on the length of the drying oven and the material speed and should be set so that the solvents are completely or at least largely completely removed from the film.
  • the resulting film is peeled off the support and cut into pieces of suitable size and shape for use.
  • 165.4 g of Kollidon 30 are at room temperature in a solution of 720 ml of water and 2660 ml of ethanol with stirring solves. Then 220.5 g of hydroxypropylmethyl cellulose are added at 55-60 ° C. and stirred vigorously until the solution is clear and homogeneous. After the mixture has cooled, 78.75 g of flavor, followed by a mixture of 26.88 g of nicotine salicylate and 31.5 g of caramel liquid in 120 ml of water are added with stirring. The clear, yellow-brown liquid is brushed on and dried under the conditions described in Example 1 and the dry film is cut into pieces of a suitable shape and size to give a nicotine dose of 1-2 mg per piece.

Abstract

Eine Zubereitung zur Anwendung in der Mundhöhle mit einer/einem an der Schleimhaut haftklebenden Schicht oder Film ist dadurch gekennzeichnet, daß die haftklebende Schicht oder der haftklebende Film eine homogene Mischung enthält, bestehend aus einem wasserlöslichen Polymer, einer Mischung nichtionischer oberflächenaktiver Stoffe, einem Polyalkohol, einem kosmetischen oder pharmazeutischen Wirkstoff, und einem Geschmacks- oder Aromastoff.

Description

Sofortige Benetzbarkeit aufweisende (r) wasserlöslicher Film oder wasserlösliche Schicht zur oralen Applikation
Die vorliegende Erfindung offenbart eine Zubereitung, die pharmazeutische Wirkstoffe und/oder die Atmung erfrischende Wirkstoffe enthalten, zur Anwendung in der Mundhöhle. Der Träger umfaßt wasserlösliche Polymere in Kombination mit bestimmten Inhaltsstoffen und hat eine therapeutische und/oder kosmetische Wirkung. Der Film wird unter Verwendung bestehender Beschichtungstechnologien aufgestrichen und getrocknet und weist eine sofortige Benetzbarkeit auf, gefolgt von schneller Auflösung/Zersetzung bei Applikation in der Mundhöhle.
An der Schleimhaut haftende (mukoadhäsive) Dosiersysteme zur Anwendung in der Mundhöhle, mit denen therapeutische und/oder kosmetische Wirkstoffe an die Mundschleimhaut abgegeben werden sollen, sind im Stand der Technik bekannt. Das US-Patent 5,047,244 beschreibt einen an der Mundschleimhaut haftenden Träger zur kontrollierten Abgabe eines therapeutischen Wirkstoffs durch das Schleimhautgewebe, der eine wasserfreie, aber hydratisierbare Polymermatrix und amorphes Siliciumdioxid enthält.
Fakultativ kann ein wasserunlöslicher Film beigefügt werden, um die Oberfläche nichtadhäsiv zu gestalten. Die WO 91/06270 des gleichen Erfinders offenbart einen dreischichtigen Film zur verlängerten Abgabe eines aktiven Wirkstoffs in der Mundhöhle.
In gleicher Weise offenbart US 4,876,092 eine flächenförmi- ge, adhäsive Zubereitung, umfassend eine adhäsive Schicht, welche bestimmte wasserlösliche und wasserunlösliche Polymere und einen wasserunlöslichen Träger enthält, welcher an der Mundschleimhaut haftet und dabei einen aktiven Wirkstoff an die Mundhöhle abgibt. Alle diese vorgenannten Vorrichtungen sind nicht vollständig wasserlöslich und verbleiben in der Mundhöhle, selbst nach Erreichen des therapeutischen Ziels, und bereiten dem Patienten ein gewisses Unbehagen im Mund, das hauptsächlich durch die Trägerschicht verursacht wird, welche einen unlöslichen Rückstand im Mund zurückläßt.
Eine Reihe von Versuchen wurde unternommen, um das ungute Gefühl in der Mundhöhle zu verringern, welches durch die Starrheit und mangelnde Flexibilität der Trägerschicht verursacht wurde, indem man weiche Filmträgβr einführte. Die Dokumente EP 0 200 508 und EP 0 381 194 schlagen die Verwendung von Polyethylenfilmen, Polyvinylacetat, Ethylen- Vinylacetat-Copolymeren, Metallfolien, Laminaten aus Stoff oder Papier und einem Plastikfilm, und ähnlichen Materialien als weiche Träger vor, wobei synthetische Harze wie Po- lyethylen, Vinylacetat-Homopolymere und Ethylen-Vinyl- Acetat bevorzugte Materialien sind.
In gleicher Weise offenbart CA 1 263 312 die Verwendung von Polyolefinen wie Polyethylen, Polypropylen, Polyester, PVC, sowie Vliesstoffen als weiche Trägermaterialien. Dennoch hinterlassen diese beim Patienten eine beträchtliche Menge von Rückständen des wasserunlöslichen Trägerfilms und verursachen daher immer noch ein unbehagliches Gefühl. Eine naheliegende Lösung zur Überwindung dieses Problems war die Entwicklung schleimhauthaftender Filme, welche vollständig zerfallen oder sich im Speichel auflösen. Fuchs und Hilmann (DE 24 49 865.5) stellten homogene, wasserlösliche Filme für buccale Zuführung von Hormonen her. Sie schlugen die Verwendung von wasserlöslichen Cellulose- derivaten wie Hydroxyethylcellulose, Hydroxypropylcellulose oder Methylhydroxypropylcellulose als Filmbildner vor.
Die beiden Patentschriften DE 36 30 603 und EP 0 219 762 offenbaren die Verwendung von quellbaren Polymeren wie Gelatine oder Maisstärke als Filmbildner, welche nach Ap- plikation in der Mundhöhle langsam zerfallen, wobei sie einen aktiven Wirkstoff freisetzen, der im Film enthalten ist. Die gleichen Polymere können ebenfalls verwendet werden, um Filme herzustellen, die zur Zahnpflege dienen sollen, entsprechend der Beschreibung in EP 0 452 446. Aber auch diese Zubereitungen rufen ebenfalls ein ungutes Gefühl im Mund hervor, insbesondere verursacht durch ihre anfängliche Starrheit und verzögerte Erweichung. Hieraus resultiert ein Bedarf für eine Komposition zur Verwendung in der Mundhöhle, die dem Erfordernis eines Wohlgefühls im Mund Rechnung trägt .
Die vorliegende Erfindung offenbart Verfahren und Zubereitungen, durch die ein unangenehmes Gefühl vermieden werden kann, und zwar durch Bereitstellen eines/einer sofortige Benetzbarkeit aufweisenden Films/Schicht zur Applikation an die Mundschleimhaut, und durch die eine Reißfestigkeit im freien Film erzielt wird, welche eine problemlose Beschichtung, Weiterverarbeitung und Verpackung eines verbraucherfreundlichen Produktes ermöglicht.
Die vorliegende Erfindung betrifft einen/eine schneilauflösende (n) Film/Schicht, der/die an der Mundhöhle haftet und dabei einen pharmazeutischen oder kosmetischen Wirkstoff abgibt, wobei der Film/die Schicht wasserlösliche Polymere, einen oder mehrere Polyalkohole und einen oder mehrere pharmazeutisch oder kosmetische wirksame Inhaltsstoffe enthält. Wahlweise kann die Formulierung eine Kombination von bestimmten Weichmachern oder oberflächenaktiven Stoffen, Farbstoffen, Süßmitteln, Geschmacksstoffen, Geschmacksverbesserern oder anderer Corrigenzien enthalten, wie sie üblicherweise zur Modifikation des Geschmacks von für die Applikation in der Mundhöhle bestimmten Formulierungen Verwendung finden. Der resultierende Film ist gekennzeichnet durch eine sofortige Benetzbarkeit, welche den Film unverzüglich nach Applikation an das Schleimhautgewebe erweichen läßt, wodurch beim Patienten ein länger anhalten- des unangenehmes Gefühl im Mund verhindert wird, sowie durch eine für normale Beschichtungs-, Schneid-, Auf- schneid- und Verpackungsoperationen geeignete Reißfestigkeit.
Der mukoadhäsive Film der vorliegenden Erfindung enthält als wesentliche Bestandteile ein wasserlösliches Polymer oder eine Kombination von wasserlöslichen Polymeren, eine oder mehrere Weichmacher oder oberflächenaktive Stoffe, ein oder mehrere Polyalkohole und einen pharmazeutischen oder kosmetischen Wirkstoff.
Die für den mukoadhäsiven Film verwendeten Polymere umfassen hydrophile und/oder wasserdispergierbare Polymere. Bevorzugte Polymere sind wasserlösliche Cellulosederivate. Hydroxypropylmethylcellulose, Hydroxyethylcellulose und Hydroxypropylcellulose sind, allein oder gemischt, besonders bevorzugt. Beispiele für andere, fakultative, Polymere werden nachfolgend genannt, ohne die Erfindung einzuschränken: Polyvinylpyrrolidon, Carboxymethylcellulose, Polyvinylalko- hol, Natriumalginat, Polyethylenglycol, natürliche Gummen wie Xanthanharz, Traganth, Guarharz, Akazienharz, Gummiara- bicum, wasserdispergierbare Polyacrylate wie Polyacryl- säure, Methylmethacrylatcopolymer, Carboxyvinylcopolymere . Die Konzentration des wasserlöslichen Polymers im fertigen Film kann zwischen 20 und 75 Gew.-% betragen. Eine bevorzugte Konzentration beträgt zwischen 50 und 75 Gew.-%.
Die für den mukoadhäsiven Film verwendeten oberflächenaktiven Stoffe können ein oder mehrere nichtionische oberflächenaktive Stoffe sein. Bei Verwendung einer Kombination von oberflächenaktiven Stoffen kann die erste Komponente ein Polyethoxysorbitan-fettsäureester oder ein α-hydro-ω- hydroxypoly(ethoxy) -poly- (propoxy) -poly(ethoxy) -Block- copolymer sein, während die zweite Komponente ein Polye- thoxyalkylether oder ein Polyethoxy-rizinusölderivat sein kann.
Bevorzugt soll der HLB-Wert der Polyethoxysorbitanfett- säurester zwischen 10 und 20 betragen, wobei ein Bereich zwischen 13 und 17 besonders bevorzugt ist. Das α-hydro-ω- hydroxypoly(ethoxy) -poly(propoxy) -poly(ethoxy) -Block- copolymer soll mindestens 35 Propoxy-Einheiten, bevorzugt mindestens 50 Propoxy-Einheiten enthalten.
Der Polyethoxyalkylether sollte einen HLB-Wert zwischen 10 und 20 besitzen, bevorzugt nicht weniger als 15. Das Polyethoxy-rizinusölderivat soll einen HLB-Wert zwischen 14 und 16 besitzen.
Um die erwünschte, sofortige Benetzbarkeit zu erreichen, soll das Verhältnis zwischen der ersten und der zweiten Komponente einer binären oberflächenaktiven Mischung zwischen 1:10 und 1:1 gehalten werden, bevorzugt zwischen 1:5 und 1:3.
Die Gesamtkonzentration der oberflächenaktiven Stoffe im fertigen Film hängt ab von den Eigenschaften der anderen Ingredienzien, soll jedoch üblicherweise zwischen 0.1 und 5 Gew. -% betragen.
Der Polyalkohol wird benötigt, um den erwünschten Weichheitsgrad des Filmes zu erreichen. Beispiele von Polyalko- holen umfassen Glycerin, Polyethylenglycol, Propylenglycol, Glycerinmonoester mit Fettsäuren, oder sonstige pharmazeutisch verwendete Polyalkohole. Die Konzentration von Polyalkohol in der Trockenmasse des Filmes beträgt üblicherweise 0.1 bis 5 Gew.-%.
Der Film ist besonders gut geeignet zur Abgabe eines weiten Bereiches pharmazeutisch aktiver Wirkstoffe durch die Schleimhautmembranen eines Patienten, insbesondere durch die buccalen Schleimhäute.
Therapeutische Wirkstoffe, die Absorptionsprobleme infolge begrenzter Löslichkeit, Abbau im Gastrointestinaltrakt oder extensiven Metabolismus haben, sind besonders gut geeignet. Als Beispiele der einsetzbaren therapeutischen Wirkstoffe sind zu nennen: Hypnotica, Sedativa, Antiepileptica, Weck- amine, Psychoneurotropica, Neuro-Muskelblocker, Antispasmo- dica, Antihistaminica, Antiallergica, Cardiotonica, Anti- arrhythmica, Diuretica, Hypotensiva, Vasopressoren, Anti- tussiva, Expectorantia, Thyroidhormone, Sexualhormone, An- tidiabetica, Antitumor-Wirkstoffe, Antibiotica sowie Chemo- therapeutica und Narcotica. Die im Film einzulagernde Menge von Wirkstoff hängt von dessen Art ab und beträgt üblicherweise zwischen 0,01 und 20 Gew.-%, sie kann jedoch, falls zur Erzielung des gewünschten Effektes notwendig, höher liegen.
Kosmetische Wirkstoffe umfassen Atemerfrischer wie Menthol, andere Geschmacks-, Aroma- oder Duftstoffe, wie sie üblicherweise für die Mundhygiene verwendet werden, und/oder Wirkstoffe für Zahnpflege und/oder Mundhygiene, beispielsweise quartäre Ammoniumbasen. Die Wirkung von Geschmacksund Aromastoffen kann durch Geschmacksverstärker wie Weinsäure, Zitronensäure, Vanillin oder dergleichen verstärkt werden.
Farbstoffe, welche wahlweise dem Film beigemischt werden, müssen hinsichtlich Toxizität sicher sein und sollten zur Verwendung in Kosmetika durch die zuständigen Behörden zugelassen sein.
Der erfindungsgemäße mukoadhäsive Film kann folgendermaßen hergestellt werden:
Der Polyalkohol, oberflächenaktive Stoffe, Weichmacher und andere mögliche Bestandteile außer dem/den wasserlöslichen oder wasserdispersiblen Polymeren werden mit einer genügenden Menge eines kompatiblen Lösungsmittels gelöst. Beispiele eines kompatiblen Lösungsmittels umfassen Wasser, Alkohole oder deren Mischungen. Nach Bildung einer klaren Lö- sung wird das wasserdispersible Polymer oder die Mischung wasserdispersibler Polymere langsam unter Rühren und, falls notwendig, Hitze zugegeben, bis eine klare und homogene Lösung gebildet ist. Diese wird auf einen Träger aufgetragen und zu einem Film getrocknet. Das Trägermaterial muß eine Oberflächenspannung haben, die es ermöglicht, die Polymer- lösung gleichmäßig über die vorgesehene Beschichtungsbreite zu verteilen, ohne daß die Lösung eingesaugt wird und somit eine destruktive Bindung zwischen Träger und Beschichtung entsteht .
Beispiele für geeignete Materialien umfassen nichtsilikoni- sierte Polyethylen-Terephthalat-Filme, nichtsiliconisiertes Kraftpapier, Polyethylen-imprägniertes Kraftpapier oder nichtsiliconisierten Polyethylenfilm.
Der Auftrag der Lösung auf das Trägermaterial kann mit jeder üblichen Vorrichtung ausgeführt werden. Eine speziell bevorzugte Auftragstechnik betrifft eine Walzenrakel- Streichmaschine .
Die Dicke der resultierenden Filmschicht hängt von der Konzentration der Feststoffe in der Beschichtungslösung sowie von der Spaltbreite der Beschichtungsmaschine ab und kann zwischen 5 und 200 um variieren. Die Trocknung des Films wird in einem Heißluftbad unter Verwendung eines Trok- kenofens, Trockentunnels, Vacuumtrockners oder anderer geeigneter Trockenvorrichtungen vorgenommen, welche die Wirkung des/der Wirkstoffs/Wirkstoffe oder der Geschmacksstof- fe nicht negativ beeinträchtigen. Um ein unangenehmes Gefühl im Mund zuverlässig zu vermeiden, soll die Filmdicke 70 um nicht überschreiten. Zur besseren Gebrauchserleichterung kann der Film in Stücke von geeigneter Größe und Form geschnitten und verpackt werden.
Die Erfindung wird anhand nachfolgender Beispiele veranschaulicht. Beispiel 1 :
15 g Sorbit, 6 g Glycerin, 0,5 g Polysorbat 80 (Tween 80),
2 g Brij 35, 25 g Zitronenminzearoma, 3 g Aspartam, 15 g 1-Menthol und 3 g Zitronensäure werden bei 60°C in einer Mixtur von 250 g Wasser und 250 g Ethanol solange gerührt, bis sich eine klare Lösung gebildet hat.
Zu der Lösung werden 30 g Hydroxypropylmethylcellulose langsam unter Rühren zugegeben, bis eine klare und homogene Lösung gebildet ist. Die resultierende Lösung wird dann bis auf Raumtemperatur abkühlen gelassen und unter Verwendung einer üblichen Beschichtungs-/Trocknungsvorrichtung auf ein geeignetes Trägermaterial aufgestrichen, beispielsweise nichtsiliconisiertes polyethylenbeschichtetes Kraftpapier. Beschichtungsspalt und Bahngeschwindigkeit müssen so geregelt werden, daß eine Trockenfilmdicke zwischen 20 und 50 um erreicht wird. Die Trockentemperatur hängt von der Länge des Trockenofens und der Materialgeschwindigkeit ab und soll so eingestellt werden, daß die Lösungsmittel vollständig, oder zumindest weitgehend vollständig vom Film entfernt werden. Der resultierende Film wird vom Träger abgelöst und zum Gebrauch in Stücke von geeigneter Größe und Form zerteilt.
Beispiel 2:
3 g Sorbit, 1,5 g Kollidon 30 (Lieferant: BASF), 5 g Glycerin, 5 g Propylenglycol, 5 g Polyethylenglycol, 4 g Polysorbat 80 (Tween 80), 8 g Brij 35, 12 g Pfefferminzaroma, 0,8 g Aspartam werden in einer Mischung von 400 g Wasser und 400 g Ethanol bei 60°C unter Rühren aufgelöst. Zu der klaren Lösung werden 28 g Hydroxypropylmethylcellulose unter Rühren langsam zugegeben. Nach völliger Auflösung des Polymers wird die Lösung auf Raumtemperatur abgekühlt und auf einen Träger unter den gleichen Beschichtungs- und TRocknungsbedingungen wie in Beispiel 1 aufgestrichen. Der trockene Film wird wieder in Stücke von geeigneter Größe und Form zerteilt.
Beispiel 3 :
15 g Sorbit, 22,5 g Glycerin, 2,5 Propylenglycol, 2,5 g Brij 35, 2,5 g Poloxamer 407, 3,5 g Cremophor RH 40, 9 g Krauterminzearoma, 0,5 g Aspartam werden unter ständigem Rühren bei 60°C in einer Mischung von 250 g Wasser und 250 g Ethanol gelöst. Zu der klaren Lösung werden 75 g Hydroxypropylcellulose unter ständigem Rühren langsam zugegeben. Mit der klaren Lösung wird wiederum beschichtet und unter den beschriebenen Bedingungen getrocknet, wie in Beispiel 1; der trockene Film wird in Stücke von geeigneter Größe und Form zerteilt.
Beispiel 4:
3,6 Tween 80, 3,6 g Glycerin, 39 g Menthol und 171 g Kollidon 30 werden bei Raumtemperatur und unter Rühren in einer Lösung aus 600 ml Wasser und 2800 ml Ethanol gelöst. 247,5 g Hydroxypropylmethylcellulose werden dann langsam und portionsweise bei 50-55 °C hinzugefügt; es wird bis zur vollständigen Auflösung gerührt. Nach Abkühlen der Mischung werden, in Folge, 90 g Zitronenminzearoma, gefolgt von einer Lösung/Suspension aus 27,13 g Aspartam, 18 g Zitronensäure und 0,17 g FD&C yellow #5 in 120 ml Wasser unter Rühren hinzugefügt. Die klare Lösung wird unter den in Beispiel 1 angegebenen Bedingungen aufgestrichen und getrocknet; der trockene Film wird in Stücke von für die beabsichtigte Verwendung geeigneter Größe und Form zerteilt.
Beispiel 5:
165,4 g Kollidon 30 werden bei Raumtemperatur in einer Lösung aus 720 ml Wasser und 2660 ml Ethanol unter Rühren ge- löst. Sodann werden 220,5 g Hydroxypropylmethylcellulose bei 55-60 °C hinzugefügt und so lange kräftig gerührt bis die Lösung klar und homogen ist. Nach Abkühlen der Mischung werden, in Folge, 78,75 g Geschmacksstoff, gefolgt von einer Mischung aus 26,88 g Nikotinsalicylat und 31,5 g Karamelflüssigkeit in 120 ml Wasser unter Rühren hinzugefügt. Die klare, gelbbraune Flüssigkeit wird unter den in Beispiel 1 beschriebenen Bedingungen aufgestrichen und getrocknet und der trockene Film in Stücke von geeigneter Form und Größe zerteilt, zur Abgabe einer Nikotindosis von 1-2 mg pro Stück.

Claims

P A T E N T A N S P R Ü C H E
1. Zubereitung zur Anwendung in der Mundhöhle mit einer/einem an der Schleimhaut haftklebenden Schicht oder Film, dadurch gekennzeichnet, daß die haftklebende Schicht oder der haftklebende Film eine homogene Mischung enthält, bestehend aus einem wasserlöslichen Polymer, einem Polyalkohol, einem kosmetischen oder pharmazeutischen Wirkstoff, und einem Geschmacks- oder Aromastoff.
2. Zubereitung nach Anspruch 1, dadurch gekennzeichnet, daß das wasserlösliche Polymer Hydroxypropylmethylcellulose, Hydroxyethylcellulose, Hydroxypropylcellulose, Po- lyvinylpyrrolidon, Carboxylmethylcellulose, Polyvinylalko- hol, Natriumalginat, Polyethylenglycol, Xanthanharz, Traganth, Guarharz, Akazienharz, Gummiarabicum, Polyacrylsäu- re, Methylmethacrylatcopolymer, Carboxyvinylcopolymere oder deren Mischungen umfaßt.
3. Zubereitung nach Anspruch 1, dadurch gekennzeichnet, daß die Konzentration des wasserlöslichen Polymers in der Trockenmasse der Filmschicht zwischen 20 und 75 Gew.-% beträgt .
4. Zubereitung nach Anspruch 1, dadurch gekennzeichnet, daß die Mischung als wahlweise Bestandteile ein oder mehrere Weichmacher oder oberflächenaktive Stoffe enthält.
5. Zubereitung nach Anspruch 4, dadurch gekennzeichnet, daß die erste Komponente einer Mischung oberflächenaktiver Stoffe ein Polyethoxysorbitan-fettsäureester oder ein α- hydro-ω-hydroxypoly(ethoxy) -poly(propoxy) -poly(ethoxy) - Blockcopolymer ist.
6. Zubereitung nach Anspruch 4, dadurch gekennzeichnet, daß die zweite Komponente des oberflächenaktiven Stoffs ein Polyethoxyalkylether oder ein Polyethoxyrizinusölderivat ist.
7. Zubereitung nach Anspruch 1, dadurch gekennzeichnet, daß der Polyalkohol ausgewählt ist aus Glycerin, Polyethy- lenglycol, Propylenglycol oder Glycerinmonoestern mit Fettsäuren.
8. Zubereitung nach Anspruch 1, dadurch gekennzeichnet, daß der therapeutische Wirkstoff ausgewählt ist aus der Gruppe von Hypnotica, Sedativa, Antiepileptica, Weckaminen, Psy- choneurotropica, Neuro-Muskelblockern, Antispasmodica, An- tihistaminica, Antiallergica, Cardiotonica, Antiarrhythmi- ca, Diuretica, Hypotensiva, Vasopressoren, Antitussiva, Ex- pectorantia, Thyroidhormonen, Sexualhormonen, Antidiabeti- ca, Antitumor-Wirkstoffen, Antibiotica sowie Chemothera- peutica oder Narcotica.
9. Zubereitung nach Anspruch 1, dadurch gekennzeichnet, daß der kosmetische Wirkstoff Atemerf ischer wie Menthol, Geschmacks-, Aroma- oder Duftstoffe, wie sie üblicherweise für Mundhygiene verwendet werden, und/oder Wirkstoffe zur Zahn- oder Mundpflege umfaßt, wie quartäre Ammoniumbasen.
PCT/EP1997/005820 1996-11-11 1997-10-22 Sofortige benetzbarkeit aufweisende(r) wasserlöslicher film oder wasserlösliche schicht zur oralen applikation WO1998020862A1 (de)

Priority Applications (19)

Application Number Priority Date Filing Date Title
AU48682/97A AU739698B2 (en) 1996-11-11 1997-10-22 Water soluble film for oral administration with instant wettability
SI9730590T SI0936905T1 (en) 1996-11-11 1997-10-22 Immediate wettability water soluble film or water soluble layer for oral application
CZ0164799A CZ297354B6 (cs) 1996-11-11 1997-10-22 Prípravek pro aplikaci v ústní dutine s filmem nebo fólií s okamzitou smácitelností
IL12981997A IL129819A0 (en) 1996-11-11 1997-10-22 A mucoadhesive composition
SK5041-2005A SK285999B6 (sk) 1996-11-11 1997-10-22 Orálne aplikovateľný prípravok majúci okamžitú zmáčateľnosť a spôsob jeho výroby
DK03014213T DK1362584T3 (da) 1996-11-11 1997-10-22 Umiddelbar befugtning af vandoplöselig film eller vandoplöselig lag til oral anvendelse
EP97911237A EP0936905B1 (de) 1996-11-11 1997-10-22 Sofortige benetzbarkeit aufweisende(r) wasserlöslicher film oder wasserlösliche schicht zur oralen applikation
CA002265651A CA2265651C (en) 1996-11-11 1997-10-22 Immediate wettability water soluble film or water soluble layer for oral application
DK97911237T DK0936905T3 (da) 1996-11-11 1997-10-22 Vandopløselig film eller vandopløseligt lag med øjeblikkelig befugtelighed til brug ved oral indgivelse
HU9904207A HU228464B1 (en) 1996-11-11 1997-10-22 Immediate wettability water soluble film or water soluble layer for oral application
AT97911237T ATE247954T1 (de) 1996-11-11 1997-10-22 Sofortige benetzbarkeit aufweisende(r) wasserlöslicher film oder wasserlösliche schicht zur oralen applikation
HU0500666A HU230022B1 (hu) 1996-11-11 1997-10-22 Azonnal nedvesedő, vízoldható film vagy vízoldható réteg orális alkalmazás céljára
JP52208898A JP4063331B2 (ja) 1996-11-11 1997-10-22 口部に適用される瞬時湿潤性の水溶性薄膜または水溶性層
DE59710670T DE59710670D1 (de) 1996-11-11 1997-10-22 Sofortige benetzbarkeit aufweisende(r) wasserlöslicher film oder wasserlösliche schicht zur oralen applikation
PL97333677A PL190376B1 (pl) 1996-11-11 1997-10-22 Preparat do stosowania w jamie ustnej
SK622-99A SK285100B6 (sk) 1996-11-11 1997-10-22 Prípravok na aplikáciu v ústnej dutine s filmom alebo fóliou s okamžitou zmáčateľnosťou
NO19991921A NO325073B1 (no) 1996-11-11 1999-04-22 Preparat for anvendelse i munnhulen med en film eller sjikt som viser oyeblikkelig fuktbarhet.
HK00101167A HK1035316A1 (en) 1996-11-11 2000-02-25 Immediate wettability water soluble film or water soluble layer for oral application
NO20053307A NO20053307D0 (no) 1996-11-11 2005-07-06 Oralt administrerbart preparat for angivelse av virksomme stoffer i munnhulen og fremgangsmate for fremstilling derav.

Applications Claiming Priority (2)

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DE19646392.0 1996-11-11
DE19646392A DE19646392A1 (de) 1996-11-11 1996-11-11 Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht

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US (8) US5948430A (de)
EP (2) EP0936905B1 (de)
JP (3) JP4063331B2 (de)
KR (2) KR100569847B1 (de)
AT (2) ATE247954T1 (de)
AU (1) AU739698B2 (de)
CA (1) CA2265651C (de)
CZ (1) CZ297354B6 (de)
DE (4) DE19646392A1 (de)
DK (2) DK0936905T3 (de)
ES (2) ES2206692T3 (de)
HK (1) HK1035316A1 (de)
HU (2) HU228464B1 (de)
ID (1) ID22526A (de)
IL (2) IL129819A0 (de)
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NO (2) NO325073B1 (de)
NZ (1) NZ335063A (de)
PL (1) PL190376B1 (de)
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