US599865A - Emanuel l - Google Patents

Emanuel l Download PDF

Info

Publication number
US599865A
US599865A US599865DA US599865A US 599865 A US599865 A US 599865A US 599865D A US599865D A US 599865DA US 599865 A US599865 A US 599865A
Authority
US
United States
Prior art keywords
pills
plate
bar
coated
dipping
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Publication date
Application granted granted Critical
Publication of US599865A publication Critical patent/US599865A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005Coating of tablets or the like

Definitions

  • My invention relates toa new and useful process and apparatus used in the dipping of pills in quantity in gelatin or any similar substance in order to manufacture What are termed gelatin-coated pills,.&c.
  • needle-bars which consist in a series of fine needles so mounted and manipulated that they are caused to impale a series of the pills and hold them upon their points during the process of dipping.
  • Certain devices have also been employed in which pneumatic suction is utilized for the same purpose. Both these apparatus are, however, objectionable, the former in that the needles necessarily leave a hole in one end of the pill, and the latter, although avoiding this difficulty, by reason of the uncertainty of its action and the complicated character of the necessary apparatus. r
  • Figure 1 represents a portion of a dippingbar coated on its lower side with an adhesive mixture and with a number of pills adhering thereto, the oval shape being shown, which is their preferred form.
  • Fig. 2 represents a spacing-plate and a base-plate to be used in connection with the dipping-bar.
  • Fig. 3 represents a base-plate by itself; and Fig. 4 repconvenient length.
  • the dipping-bar A may be of any I find that eighteen or twenty inches makes a convenient size. If it be desired to manipulate a larger number of pills simultaneously, a rectangular plate may be employed capable of holding amumber of rows at a time; but I have illustrated my invention only with reference to the handling of a single row of pills.
  • the lower side of the dipping-barA is coated to some depth with 7 a cleanly separable adhesive substance, as indicated at a.
  • adhesive substance in this connection means a substance having"6 5 such physicalproperties that when a light object, such as a pill, is pressed against it it will hold to its surface against the action of gravity with considerable firmness, and this even though the surface of thepill be oov- 7o ered with a coating of as smooth a substance as hard gelatin. Adhesiveness alone is, however, insufficient for my purpose, as there is a very large class of adhesive substances which would satisfy the foregoing requirements, and yet which would be wholly inapplicable to my purpose.
  • a spacing-plate B To hold the pills in position for being operated upon, a spacing-plate B, Fig. 2, is employed. In this plate there is a row of holes I find that amixture of beeswax v. I
  • This plate is of such thickness that an ordinary oval pill will project at one end appreciably above the surface of the hole, while at the same time fitting with reasonable snugness within it.
  • the edges of the holes are chamfered. The holes project clean through the plate, and in order to prevent the pills from falling through a base-plate O, the surface of which may be covered with chamois-skin or felt c, is placed below the spacing-plate.
  • the first step in my process is to sprinkle over the spacing-plate a number of uncoated pills until one has fallen in each of the holes.
  • the surplus pills are then removed and the dipping-bar pressed firmly down upon the projecting ends of the row which occupies the spacing-plate, as is seen in Fig. 4:.
  • each pill will adhere to the dipping-bar, which is then raised quite vertically, carrying with it the entire line of pills D.
  • the bar, with its adhering pills, is then set aside to dry. At this point it is evident that the lower half of the pill is coated; but the upper half is uncoated.
  • the next step in the operation is the inversion of the half-coated pills, which is accomplished as follows: The bar carrying them is carefully replaced over the spacing-plate until one pill occupies each hole. By a slight sidewise motion the bar is removed, leaving all of the pills in their holes. A second baseplate 0 Fig. 3, is then inverted and placed on top of the spacing-plate, which, with its upper and lower base-plate, is then itself in verted. hat was previously the lower and has now become the upper base-plate is then removed, leaving the coated extremities of the pills exposed upwardly.
  • the dippingbar (or a similar bar, for it must be understood that a number of these bars may be kept in use simultaneously) is then pressed upon the coated ends of the pills, which, as before, adhere to the bar and are raised all together and dipped within the gelatin to a sufficient depth to complete their coating. They are then set aside a second time to dry, and when dried are brushed from the bar and are ready for use.
  • Pills so dipped, if the manipulation is properly effected, are of a very regular elliptical form and have no objectionable holes at their ends, such as are always present in pills which have been dipped by the use of a needle-bar.
  • I claim- 1 The process of coating pills which consists in the following steps: first, applying to a series of pills held in convenient proximity to each other a bar or plate the surface of which is coated with a cleanly separable adhesive substance and pressing the same down upon the pills until they adhere thereto; second, transferring this series of adhering pills to, and dipping them to a portion of their depth within, a bath of the desired coating; third, allowing the series of pills thus partially coated to dry; fourth, pressing upon the coated extremities of the series of pills a similar bar coated with adhesive substance until the entire series of pills adhere to the latter bar by their coated extremities; and, fifth, again transferring and dipping the entire series within the bath containing the desired coating to a sufficient depth to coat the uncoated surface of the pills, substantially as described.
  • An apparatus for dipping pills which consists of the space-plate, B, the base-plate, O, and the bar or plate, A, having its lower surface coated with a cleanly separable adhesive substance, such as wax, substantially as described.

Description

(No Model.)
r E. L. RICHARDS.
PROCESS OF AND-APPARATUS FOR DIPPING PILLS. No. 599,865. Patented Mar. 1; 1898.
WITNESSES: INVENTOR:
UNITED "STATES ATENT FFICE.
EMANUEL L. RICHARDS, OF PHILADELPHIA, PENNSYLVANIA, ASSIGNOR TO HANCE BROS. & WHITE, OF SAME PLACE.
PROCESS OF AND APPARATUS FOR DIPPING PILLS.
SPECIFICATION forming part of Letters Patent No. 599,865, dated March 1, 1898. 7 Application filed November 27; 1896. 7 Serial No. 613,487. (No model.)
To all whom it may concern:
Be it known that I, EMANUEL L. RICHARDS, of Philadelphia, in the State of Pennsylvania, have invented certain new and useful Improvement-s in Processes of and Apparatus for Dipping Pills, of which the following is a specification, reference being had to the accompanying drawings.
My invention relates toa new and useful process and apparatus used in the dipping of pills in quantity in gelatin or any similar substance in order to manufacture What are termed gelatin-coated pills,.&c. For this purpose hitherto it has been customary to employ what are termed needle-bars, which consist in a series of fine needles so mounted and manipulated that they are caused to impale a series of the pills and hold them upon their points during the process of dipping. Certain devices have also been employed in which pneumatic suction is utilized for the same purpose. Both these apparatus are, however, objectionable, the former in that the needles necessarily leave a hole in one end of the pill, and the latter, although avoiding this difficulty, by reason of the uncertainty of its action and the complicated character of the necessary apparatus. r
In my invention I employ a bar or plate a surface of which is coatedwith an adhesive preparation, such as Wax, having certain physical properties, as will be hereinafter explained, and I find that by the proper arrangements of its parts, as indicated in the following specification and drawings, it is possible ,to accurately lift and dip simultaneously a number of pills with a very small expenditure of manual labor, the apparatus being very simple and inexpensive.
The apparatus by which I carry out my processis illustrated in the accompanying drawings, in which-.-
Figure 1 represents a portion of a dippingbar coated on its lower side with an adhesive mixture and with a number of pills adhering thereto, the oval shape being shown, which is their preferred form. Fig. 2 represents a spacing-plate and a base-plate to be used in connection with the dipping-bar. Fig. 3 represents a base-plate by itself; and Fig. 4 repconvenient length.
resents in vertical cross-section the dippingbar, spacing-plate, and base-plate, all in situ. The dipping-bar A, Fig.1, may be of any I find that eighteen or twenty inches makes a convenient size. If it be desired to manipulate a larger number of pills simultaneously, a rectangular plate may be employed capable of holding amumber of rows at a time; but I have illustrated my invention only with reference to the handling of a single row of pills. The lower side of the dipping-barAis coated to some depth with 7 a cleanly separable adhesive substance, as indicated at a. By adhesive substance in this connection I mean a substance having"6 5 such physicalproperties that when a light object, such as a pill, is pressed against it it will hold to its surface against the action of gravity with considerable firmness, and this even though the surface of thepill be oov- 7o ered with a coating of as smooth a substance as hard gelatin. Adhesiveness alone is, however, insufficient for my purpose, as there is a very large class of adhesive substances which would satisfy the foregoing requirements, and yet which would be wholly inapplicable to my purpose. The additional requirement I have expressed by the words cleanly separable, meaning thereby, on the one hand, to exclude all substances which by reason of their viscid, slimy, or ropy consistency would stick so firmly to the pill that when removed a portion of the adhesive substance would remain on the surface of the pill, and also, on the other hand, to exclude all those adhesive substances which (usually by reason of their being readily soluble in Water) would tend to dry rapidly and set firmly upon the pill, so that they would forbid the removal ofthe pill without breaking 0 such, for instance, as paste or mucilage proper. and rosin in proper proportions (depending upon the temperature at which the operation is carried on) has the desired consistency and 5 possesses all the physical properties which are required by my operation.
To hold the pills in position for being operated upon, a spacing-plate B, Fig. 2, is employed. In this plate there is a row of holes I find that amixture of beeswax v. I
b, corresponding to the positions which it is desired that the pills shall take. This plate is of such thickness that an ordinary oval pill will project at one end appreciably above the surface of the hole, while at the same time fitting with reasonable snugness within it. In order to facilitate the filling of the spacing-plate with the pills, the edges of the holes are chamfered. The holes project clean through the plate, and in order to prevent the pills from falling through a base-plate O, the surface of which may be covered with chamois-skin or felt c, is placed below the spacing-plate.
The first step in my process is to sprinkle over the spacing-plate a number of uncoated pills until one has fallen in each of the holes. The surplus pills are then removed and the dipping-bar pressed firmly down upon the projecting ends of the row which occupies the spacing-plate, as is seen in Fig. 4:. If care be taken as to the consistency of the wax, each pill will adhere to the dipping-bar, which is then raised quite vertically, carrying with it the entire line of pills D. Thus held the pills are dipped in a bath of gelatin or whatever substance the pills are to be coated with to at least half their depth, great care being taken not to dip deep enough to get any of the gelatin upon the wax. The bar, with its adhering pills, is then set aside to dry. At this point it is evident that the lower half of the pill is coated; but the upper half is uncoated.
The next step in the operation is the inversion of the half-coated pills, which is accomplished as follows: The bar carrying them is carefully replaced over the spacing-plate until one pill occupies each hole. By a slight sidewise motion the bar is removed, leaving all of the pills in their holes. A second baseplate 0 Fig. 3, is then inverted and placed on top of the spacing-plate, which, with its upper and lower base-plate, is then itself in verted. hat was previously the lower and has now become the upper base-plate is then removed, leaving the coated extremities of the pills exposed upwardly. The dippingbar (or a similar bar, for it must be understood that a number of these bars may be kept in use simultaneously) is then pressed upon the coated ends of the pills, which, as before, adhere to the bar and are raised all together and dipped within the gelatin to a sufficient depth to complete their coating. They are then set aside a second time to dry, and when dried are brushed from the bar and are ready for use.
Pills so dipped, if the manipulation is properly effected, are of a very regular elliptical form and have no objectionable holes at their ends, such as are always present in pills which have been dipped by the use of a needle-bar.
Having thus described my invention, I claim- 1. The process of coating pills which consists in the following steps: first, applying to a series of pills held in convenient proximity to each other a bar or plate the surface of which is coated with a cleanly separable adhesive substance and pressing the same down upon the pills until they adhere thereto; second, transferring this series of adhering pills to, and dipping them to a portion of their depth within, a bath of the desired coating; third, allowing the series of pills thus partially coated to dry; fourth, pressing upon the coated extremities of the series of pills a similar bar coated with adhesive substance until the entire series of pills adhere to the latter bar by their coated extremities; and, fifth, again transferring and dipping the entire series within the bath containing the desired coating to a sufficient depth to coat the uncoated surface of the pills, substantially as described.
2. An apparatus for dipping pills, which consists of the space-plate, B, the base-plate, O, and the bar or plate, A, having its lower surface coated with a cleanly separable adhesive substance, such as wax, substantially as described.
EMANUEL L. RICHARDS.
Vitnesses:
G. HERBERT JENKINS, E. Russia.
US599865D Emanuel l Expired - Lifetime US599865A (en)

Publications (1)

Publication Number Publication Date
US599865A true US599865A (en) 1898-03-01

Family

ID=2668505

Family Applications (1)

Application Number Title Priority Date Filing Date
US599865D Expired - Lifetime US599865A (en) Emanuel l

Country Status (1)

Country Link
US (1) US599865A (en)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2456082A (en) * 1943-09-30 1948-12-14 Rca Corp Art of metalizing nonmetallic bodies
US2812740A (en) * 1954-10-04 1957-11-12 Owens Illinois Glass Co Apparatus for wax coating scientific glassware
US2949388A (en) * 1957-10-11 1960-08-16 Illinois Tool Works Method for coating modules with a heat curable protective coating material
US4820524A (en) * 1987-02-20 1989-04-11 Mcneilab, Inc. Gelatin coated caplets and process for making same
US4867983A (en) * 1987-02-20 1989-09-19 Mcneilab, Inc. Method for double dipping gelating coated caplets
US4965089A (en) * 1989-04-10 1990-10-23 Sauter Manufacturing Corp. Method and apparatus for the gelatin coating of caplets
US4966771A (en) * 1987-02-20 1990-10-30 Mcneilab, Inc. Gelatin coated caplets and process for making same
US4990358A (en) * 1987-02-20 1991-02-05 Mcneilab, Inc. Method for double dipping gelatin coated caplets
US5198227A (en) * 1990-01-22 1993-03-30 Mcneil-Ppc, Inc. Dual subcoated simulated capsule medicament
US5464631A (en) * 1990-06-27 1995-11-07 Warner-Lambert Company Encapsulated dosage forms
US5514216A (en) * 1993-07-07 1996-05-07 Bayer Corporation (Formerly Miles, Inc.) Apparatus for holding solid compact medicaments during coating processing
US5658589A (en) * 1989-04-28 1997-08-19 Mcneil-Ppc, Inc. Subcoated simulated capsule-like medicament
WO1999004645A1 (en) * 1997-07-24 1999-02-04 Bayer Corporation Process and apparatus for the gelatin coating of medicaments
US6080426A (en) * 1994-12-16 2000-06-27 Warner-Lamberg Company Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process
US6245350B1 (en) 1994-12-16 2001-06-12 Warner-Lambert Company Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process
US20030068373A1 (en) * 2001-09-28 2003-04-10 Joseph Luber Immediate release tablet
US20030068367A1 (en) * 2001-09-28 2003-04-10 Sowden Harry S. Systems, methods and apparatuses for manufacturing dosage forms
US20030124183A1 (en) * 2001-09-28 2003-07-03 Sowden Harry S. Systems, methods and apparatuses for manufacturing dosage forms
US20030217908A1 (en) * 2001-09-28 2003-11-27 Sowden Harry S. Method and apparatus for transferring substrates
US20030232083A1 (en) * 2001-09-28 2003-12-18 David Wynn Modified release dosage form
US20040126425A1 (en) * 2001-09-28 2004-07-01 Sowden Harry S. Systems, methods and apparatuses for manufacturing dosage forms
US20040156902A1 (en) * 2002-09-28 2004-08-12 Der-Yang Lee Composite dosage forms having an inlaid portion
US20040175425A1 (en) * 2001-09-28 2004-09-09 Sowden Harry S. Systems, methods and apparatuses for manufacturing dosage forms
US20050008696A1 (en) * 2001-09-28 2005-01-13 Sowden Harry S. Systems, methods and apparatuses for manufacturing dosage forms
US20060233881A1 (en) * 2005-04-15 2006-10-19 Sowden Harry S Modified release dosage form
US7392151B2 (en) 2003-03-25 2008-06-24 Sandvik Mining And Construction Oy Initializing position and direction of mining vehicle
US7838026B2 (en) 2001-09-28 2010-11-23 Mcneil-Ppc, Inc. Burst-release polymer composition and dosage forms comprising the same

Cited By (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2456082A (en) * 1943-09-30 1948-12-14 Rca Corp Art of metalizing nonmetallic bodies
US2812740A (en) * 1954-10-04 1957-11-12 Owens Illinois Glass Co Apparatus for wax coating scientific glassware
US2949388A (en) * 1957-10-11 1960-08-16 Illinois Tool Works Method for coating modules with a heat curable protective coating material
US5314537A (en) * 1987-02-20 1994-05-24 Mcneilab, Inc. Gelatin coated caplets and process for making same
US4820524A (en) * 1987-02-20 1989-04-11 Mcneilab, Inc. Gelatin coated caplets and process for making same
US4867983A (en) * 1987-02-20 1989-09-19 Mcneilab, Inc. Method for double dipping gelating coated caplets
US4966771A (en) * 1987-02-20 1990-10-30 Mcneilab, Inc. Gelatin coated caplets and process for making same
US4990358A (en) * 1987-02-20 1991-02-05 Mcneilab, Inc. Method for double dipping gelatin coated caplets
US4965089A (en) * 1989-04-10 1990-10-23 Sauter Manufacturing Corp. Method and apparatus for the gelatin coating of caplets
US5770225A (en) * 1989-04-28 1998-06-23 Mcneil-Ppc, Inc. Process of preparing a subcoated simulated capsule-like medicament
US6214380B1 (en) 1989-04-28 2001-04-10 Mcneil-Ppc, Inc. Subcoated simulated capsule-like medicament
US5658589A (en) * 1989-04-28 1997-08-19 Mcneil-Ppc, Inc. Subcoated simulated capsule-like medicament
US7087242B2 (en) 1989-04-28 2006-08-08 Mcneil-Ppc, Inc. Subcoated simulated capsule-like medicament
US5916592A (en) * 1989-04-28 1999-06-29 Mcneil-Ppc, Inc. Subcoated simulated capsule-like medicament
US20020031546A1 (en) * 1989-04-28 2002-03-14 Parekh Kishor B. Subcoated simulated capsule-like medicament
US6120801A (en) * 1989-04-28 2000-09-19 Mcneil-Ppc, Inc. Subcoated simulated capsule-like medicament
US6326026B1 (en) 1989-04-28 2001-12-04 Mcneil-Ppc, Inc. Subcoated simulated capsule-like medicament
US5198227A (en) * 1990-01-22 1993-03-30 Mcneil-Ppc, Inc. Dual subcoated simulated capsule medicament
US5296233A (en) * 1990-01-22 1994-03-22 Mcneil-Ppc, Inc. Dual subcoated simulated capsule-like medicament
US5464631A (en) * 1990-06-27 1995-11-07 Warner-Lambert Company Encapsulated dosage forms
US5514216A (en) * 1993-07-07 1996-05-07 Bayer Corporation (Formerly Miles, Inc.) Apparatus for holding solid compact medicaments during coating processing
US6080426A (en) * 1994-12-16 2000-06-27 Warner-Lamberg Company Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process
US6245350B1 (en) 1994-12-16 2001-06-12 Warner-Lambert Company Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process
US6195911B1 (en) 1997-07-24 2001-03-06 Bayer Corporation Process and apparatus for drying a plurality of dip-coated medicaments
US6132159A (en) * 1997-07-24 2000-10-17 Bayer Corporation Process and apparatus for reorienting medicaments to be coated
US6258400B1 (en) 1997-07-24 2001-07-10 Bayer Corporation Process and apparatus for holding medicaments to be coated
US6126987A (en) * 1997-07-24 2000-10-03 Boyer Corporation Process for the gelatin coating of medicaments
US5942034A (en) * 1997-07-24 1999-08-24 Bayer Corporation Apparatus for the gelatin coating of medicaments
WO1999004645A1 (en) * 1997-07-24 1999-02-04 Bayer Corporation Process and apparatus for the gelatin coating of medicaments
US6742646B2 (en) 2001-09-28 2004-06-01 Mcneil-Ppc, Inc. Systems, methods and apparatuses for manufacturing dosage forms
US6982094B2 (en) 2001-09-28 2006-01-03 Mcneil-Ppc, Inc. Systems, methods and apparatuses for manufacturing dosage forms
US20030217908A1 (en) * 2001-09-28 2003-11-27 Sowden Harry S. Method and apparatus for transferring substrates
US20030232083A1 (en) * 2001-09-28 2003-12-18 David Wynn Modified release dosage form
US20040062804A1 (en) * 2001-09-28 2004-04-01 Der-Yang Lee Modified release dosage forms
US20030068367A1 (en) * 2001-09-28 2003-04-10 Sowden Harry S. Systems, methods and apparatuses for manufacturing dosage forms
US20040126425A1 (en) * 2001-09-28 2004-07-01 Sowden Harry S. Systems, methods and apparatuses for manufacturing dosage forms
US20040137057A1 (en) * 2001-09-28 2004-07-15 Sowden Harry S. Systems, methods and apparatuses for manufacturing dosage forms
US6767200B2 (en) 2001-09-28 2004-07-27 Mcneil-Ppc, Inc. Systems, methods and apparatuses for manufacturing dosage forms
US8673190B2 (en) 2001-09-28 2014-03-18 Mcneil-Ppc, Inc. Method for manufacturing dosage forms
US20040170750A1 (en) * 2001-09-28 2004-09-02 Bunick Frank J. Edible composition and dosage form comprising an edible shell
US20040175425A1 (en) * 2001-09-28 2004-09-09 Sowden Harry S. Systems, methods and apparatuses for manufacturing dosage forms
US20040191044A1 (en) * 2001-09-28 2004-09-30 Sowden Harry S. Systems, methods and apparatuses for manufacturing dosage forms
US20040213849A1 (en) * 2001-09-28 2004-10-28 Sowden Harry S. Modified release dosage forms
US20040241208A1 (en) * 2001-09-28 2004-12-02 Sowden Harry S. Fondant-based pharmaceutical composition
US6837696B2 (en) 2001-09-28 2005-01-04 Mcneil-Ppc, Inc. Apparatus for manufacturing dosage forms
US20050008696A1 (en) * 2001-09-28 2005-01-13 Sowden Harry S. Systems, methods and apparatuses for manufacturing dosage forms
US6880694B2 (en) 2001-09-28 2005-04-19 Harry S. Sowden Method and apparatus for transferring substrates
US20050129763A1 (en) * 2001-09-28 2005-06-16 Sowden Harry S. Systems, methods and apparatuses for manufacturing dosage forms
US20050126886A1 (en) * 2001-09-28 2005-06-16 Sowden Harry S. Method and apparatus for transferring substrates
US20050147677A1 (en) * 2001-09-28 2005-07-07 Sowden Harry S. Systems, methods and apparatuses for manufacturing dosage forms
US20030124183A1 (en) * 2001-09-28 2003-07-03 Sowden Harry S. Systems, methods and apparatuses for manufacturing dosage forms
US20030068373A1 (en) * 2001-09-28 2003-04-10 Joseph Luber Immediate release tablet
US8545887B2 (en) 2001-09-28 2013-10-01 Mcneil-Ppc, Inc. Modified release dosage forms
US20060246136A1 (en) * 2001-09-28 2006-11-02 Sowden Harry S Systems, methods and apparatuses for manufacturing dosage forms
US7182199B2 (en) 2001-09-28 2007-02-27 Mcneil-Ppc, Inc. Systems, methods and apparatuses for manufacturing dosage forms
US7217381B2 (en) 2001-09-28 2007-05-15 Mcneil-Ppc, Inc. Systems, methods and apparatuses for manufacturing dosage forms
US7240785B2 (en) 2001-09-28 2007-07-10 Mcneil-Ppc, Inc. Method and apparatus for transferring substrates
US7297345B2 (en) 2001-09-28 2007-11-20 Mcneil-Ppc, Inc. Systems, methods and apparatuses for manufacturing dosage forms
US7323192B2 (en) 2001-09-28 2008-01-29 Mcneil-Ppc, Inc. Immediate release tablet
US7323129B2 (en) 2001-09-28 2008-01-29 Omj Ireland Limited Systems, methods and apparatuses for manufacturing dosage forms
US7361006B2 (en) 2001-09-28 2008-04-22 Mcneil-Ppc, Inc. Systems, methods and apparatuses for manufacturing dosage forms
US8114328B2 (en) 2001-09-28 2012-02-14 Mcneil-Ppc, Inc. Method of coating a dosage form comprising a first medicant
US20090155372A1 (en) * 2001-09-28 2009-06-18 Shun-Por Li Method of manufacturing modified release dosage forms
US7972624B2 (en) 2001-09-28 2011-07-05 Shun-Por Li Method of manufacturing modified release dosage forms
US7838026B2 (en) 2001-09-28 2010-11-23 Mcneil-Ppc, Inc. Burst-release polymer composition and dosage forms comprising the same
US7968120B2 (en) 2001-09-28 2011-06-28 Mcneil-Ppc, Inc. Modified release dosage forms
US7807197B2 (en) 2002-09-28 2010-10-05 Mcneil-Ppc, Inc. Composite dosage forms having an inlaid portion
US20040156902A1 (en) * 2002-09-28 2004-08-12 Der-Yang Lee Composite dosage forms having an inlaid portion
US7392151B2 (en) 2003-03-25 2008-06-24 Sandvik Mining And Construction Oy Initializing position and direction of mining vehicle
US20060233881A1 (en) * 2005-04-15 2006-10-19 Sowden Harry S Modified release dosage form
US8673352B2 (en) 2005-04-15 2014-03-18 Mcneil-Ppc, Inc. Modified release dosage form

Similar Documents

Publication Publication Date Title
US599865A (en) Emanuel l
US995798A (en) Cake-hanger.
US1605903A (en) Starch veueebiire pbocbss aetd apparatus
US356450A (en) Manufacture of candies
US1115426A (en) Coating-machine.
US1607664A (en) Brick-ice-cream holder
US1573425A (en) Process of making artificial stone
US2363306A (en) Process of making flame coloring sticks
US1375560A (en) Germicide-brush
US278958A (en) William s
US546525A (en) Office
US344783A (en) John krehbiel
US1107325A (en) Candy and process of making the same.
US1166071A (en) Dipping-machine.
US1148566A (en) Brush.
US574960A (en) Device for dipping chocolates
US2570093A (en) Method of painting shoe buckles
US1082234A (en) Machine for coating confections.
US299571A (en) Manufacture of enameled brick
US111638A (en) Improvement in apparatus for the manufacture of confectionery
US459066A (en) Process of treating fabrics for ornamentation
US1664034A (en) Process of coating manufactured products
US279209A (en) Process of and apparatus for the manufacture of dipped candies
US859124A (en) Apparatus for ornamenting candy.
US452522A (en) Method of producing human-hair scenery and ornaments