US20080280840A1 - Meloxicam for the treatment of respiratory diseases in pigs - Google Patents

Meloxicam for the treatment of respiratory diseases in pigs Download PDF

Info

Publication number
US20080280840A1
US20080280840A1 US12/114,509 US11450908A US2008280840A1 US 20080280840 A1 US20080280840 A1 US 20080280840A1 US 11450908 A US11450908 A US 11450908A US 2008280840 A1 US2008280840 A1 US 2008280840A1
Authority
US
United States
Prior art keywords
pharmaceutical composition
meloxicam
disease
respiratory
pigs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/114,509
Inventor
Ingo Lang
Ioannis Papatsas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Vetmedica GmbH
Original Assignee
Boehringer Ingelheim Vetmedica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmedica GmbH filed Critical Boehringer Ingelheim Vetmedica GmbH
Priority to US12/114,509 priority Critical patent/US20080280840A1/en
Publication of US20080280840A1 publication Critical patent/US20080280840A1/en
Priority to US14/183,744 priority patent/US20140179639A1/en
Priority to US15/908,470 priority patent/US10548901B2/en
Assigned to BOEHRINGER INGELHEIM VETMEDICA GMBH reassignment BOEHRINGER INGELHEIM VETMEDICA GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: LANG, INGO, PAPATSAS, IOANNIS
Priority to US16/719,681 priority patent/US11083731B2/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses

Definitions

  • the invention relates to the use of meloxicam or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment or prevention of respiratory diseases in pigs.
  • Respiratory disease in pigs belongs to the most important health problems in swine production. Porcine respiratory disease is primarily caused by infectious agents, but environmental factors have a strong influence.
  • the relevant pathogens include mycoplasmas, bacteria, and viruses (e.g., G. Christensen, V. Sorensen, and J. Mousing, Diseases of the Respiratory System, In: Diseases of Swine , B. E. Straw, S. D'Allaire, W. L. Mengeling, & D. J. Taylor (eds), Iowa State University Press, Ames, Iowa (1999) pp. 913-940).
  • porcine respiratory disease The most important measures for the control of porcine respiratory disease are to improve herd management and housing conditions and introduce a vaccination program. However, if pigs have developed respiratory disease, they have to be treated.
  • cyclooxygenase-2 plays a relevant role in the pathophysiology of porcine pleuropneumonia caused by Actinobacillus pleuropneumoniae .
  • Isolated porcine alveolar macrophages increase their COX-2 activity after exposure to Actinobacillus pleuropneumoniae (W. S. Cho & C. Chae, In vitro Effects of Actinobacillus pleuropneumoniae on Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in Porcine Alveolar Macrophages, Am J Vet Res 64, (2003) pp. 1514-1518).
  • in situ hybridization W. S. Cho & C.
  • acetylsalicylic acid can be used for the treatment of pigs with respiratory disease.
  • aspirin acetylsalicylic acid
  • Ketoprofen and, to a lesser extent, flunixin decrease fever induced by experimental infection with Actinobacillus pleuropneumoniae (J. M. Swinkels, A. Pijpers, J. C. Vernooy, A. Van Nes, & J. H.
  • Ketoprofen was further tested in a controlled, blinded clinical field study (M. F. De Jong, O, Sampimon, J. P. Arnaud, G. Theunissen, G. Groenland, & P. J. Werf, A Clinical Study with a Non Steroid Antiinflammatory Drug, 14, (1996) 659 IPVS). In this study, ketoprofen had no effect on clinical score, relapse, or cure rate.
  • Meloxicam is a non-steroidal anti-inflammatory compound that belongs to the oxicam class and exerts potent anti-inflammatory, anti-exudative, and anti-pyretic activity.
  • the efficacy of meloxicam as an adjunctive therapy in the treatment of respiratory infections in cattle has been widely proven.
  • Recently meloxicam was approved for the treatment of MMA (A. Hirsch et al., J Vet Pharmacol Therap 26 (2003) pp. 355-360) and locomotor disorders in pigs (G. Friton et al., Berl Münch Tiermaschinemaschineschztl Wschr 116 (2003) pp. 421-426).
  • the problem underlying the present invention was to provide a medication for the prevention or treatment of respiratory diseases in pigs, one of the most important health problems in swine production.
  • meloxicam can be used for the treatment or prevention of respiratory diseases in pigs.
  • the invention relates to the use of meloxicam or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment or prevention of respiratory diseases in pigs.
  • the invention relates to a method of treating or preventing respiratory diseases in pigs, which method comprises administering an effective amount of meloxicam to the pigs in need thereof.
  • the invention relates to veterinary preparation containing meloxicam as well as at least one antibiotic selected from the group consisting of ⁇ -lactams, quinolones, tetracyclines, sulfonamides, fenicoles, and macrolides.
  • Another aspect of the invention is a ready-to-use two-component system for the treatment of respiratory diseases in pigs, wherein:
  • Still another aspect of the invention is an article of manufacture comprising packaging material contained within which is a composition consisting of meloxicam and a pharmaceutically acceptable carrier, and a label which indicates that the composition can be used to treat or prevent respiratory diseases in pigs.
  • FIG. 1 shows the incidence of fever (rectal temperature ⁇ 40.56° C.) in percent following the first treatment in a group of pigs treated with oxytetracycline and meloxicam ( ⁇ ), in a group of pigs treated with oxytetracycline alone ( ⁇ ), and in the untreated control ( ⁇ ).
  • FIG. 2 shows the efficacy of meloxicam in drinking water in reducing lung lesions caused by experimental Swine Influenza Virus (SIV) infection on study days 7 and 14.
  • SIV Swine Influenza Virus
  • the invention relates to the use of meloxicam or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition in a form suitable for systemic or oral administration for the treatment or prevention of respiratory diseases in pigs.
  • Meloxicam (4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide) of formula
  • NSAIDs non-steroidal-anti-inflammatory drugs
  • Meloxicam and the sodium and meglumine salt thereof are described in EP-A-0 002 482 (corresponding to U.S. Pat. No. 4,233,299), each of which is hereby incorporated by reference.
  • Meloxicam may be used according to the invention in the form of a physiologically acceptable acid addition salt.
  • physiologically acceptable acid addition salts are meant, according to the invention, the meglumine, sodium, potassium, or ammonium salt, preferably the meloxicam meglumine salt.
  • the pharmaceutical composition is administered corresponding to a daily dose of meloxicam ranging from 0.01 mg/kg to 5.0 mg/kg, preferably from 0.1 mg/kg to 3.5 mg/kg, in particular from 0.2 mg/kg to 2.0 mg/kg.
  • the pharmaceutical composition is preferably administered in a form suitable for injection, in particular for intramuscular injection, or in form of water soluble granules for administration via drinking water or as top dressing on feed.
  • a suitable injection formulation is disclosed, for example, in Example 25 of EP-A-0 002 482.
  • injection solutions may additionally contain excipients selected from among citric acid, lecithin, gluconic acid, tartaric acid, phosphoric acid and EDTA or the salts thereof as disclosed in the Examples 1 to 5 of the International Patent Application WO 01/97813 (corresponding to U.S. Patent App. Pub No. 2002/0035107), each of which is hereby incorporated by reference.
  • an injection solution of meloxicam for needleless injections is disclosed in the International Patent Application WO 03/049733 (corresponding to U.S. Patent App. Pub No. 2003/0119825), each of which is hereby incorporated by reference.
  • Suitable water soluble granules for administration via drinking water or as top dressing on feed are, for example, disclosed in the International Patent Application PCT/EP03/11802 (corresponding to U.S. Patent App. Pub No. 2004/0234596), each of which is hereby incorporated by reference.
  • the meloxicam granules contain a binder which may be selected from among hydroxypropylmethylcellulose, polyvinylpyrrolidone, gelatine, starch, and polyethylene glycol ether, preferably hydroxypropylmethylcellulose, polyvinylpyrrolidone, and polyethylene glycol ether, and most preferably hydroxypropylmethylcellulose and polyvinylpyrrolidone.
  • a binder which may be selected from among hydroxypropylmethylcellulose, polyvinylpyrrolidone, gelatine, starch, and polyethylene glycol ether, preferably hydroxypropylmethylcellulose, polyvinylpyrrolidone, and polyethylene glycol ether, and most preferably hydroxypropylmethylcellulose and polyvinylpyrrolidone.
  • meloxicam granules contain a sweetener, which may be selected from among sodium saccharine, aspartame, and SUNETT® (acesulfame K), preferably sodium saccharine or aspartame.
  • a sweetener which may be selected from among sodium saccharine, aspartame, and SUNETT® (acesulfame K), preferably sodium saccharine or aspartame.
  • meloxicam granules containing a flavoring agent which may be selected from among vanilla, honey flavoring, apple flavoring, and contramarum, preferably honey flavoring and apple flavoring.
  • meloxicam granules in which the carrier is selected from among lactose, glucose, mannitol, xylitol, sucrose, and sorbitol, preferably glucose, lactose, or sorbitol, more preferably glucose or lactose, and most preferably glucose.
  • the carrier is selected from among lactose, glucose, mannitol, xylitol, sucrose, and sorbitol, preferably glucose, lactose, or sorbitol, more preferably glucose or lactose, and most preferably glucose.
  • meloxicam granules in which the content of meloxicam is between 0.05% and 4%, preferably between 0.1% and 2%, preferably between 0.3% and 1.8%, more preferably between 0.4% and 1.5%, and most preferably 1.2%. Also particularly preferred are meloxicam granules which contain meglumine and meloxicam in a molar ratio of about 9:8 to 12:8, preferably 10:8.
  • Meloxicam can be used according to the invention to treat or prevent respiratory diseases in any breed of swines.
  • pigs selected from the swine breeds American Landrace, American Yorkshire, Angeln Saddleback, Arapawa Island, Ba Xuyen, Bantu, Bazna, Beijing Black, else Black Pied, Belgian Landrace, Bentheim Black Pied, Berkshire, Black Slavonian, British Landrace, British Lop, Bulgarian White, Cantonese, Chester White, Czech Improved White, Danish Landrace, Dermantsi Pied, Duroc, Dutch Landrace, Fengjing, Finnish Landrace, French Landrace, German Landrace, Gloucestershire Old Spots, Guinea Hog, Hampshire, Hereford, Hezuo, Iberian, Italian Landrace, Jinhua, Kele, Krskopolje, Kunekune, Lacombe, Large Black, Large Black-white, Large White, Lithuanian Native, Mangalitsa, Meishan, Middle White, Minzhu, Mong Cai, Mukota
  • meloxicam is in conjunction with an antibiotic, preferably selected from the group consisting of ⁇ -lactams, quinolones, tetracyclines, sulfonamides, fenicoles, and macrolides. Most preferred are amoxicillin, oxytetracycline, florfenicol, tylosin, tilmicosin, and sulfamethazine.
  • the dose of antibiotic is not critical per se and depends strongly on the different efficacies of the antibiotics used. As a rule up to 150.0 mg/kg, preferably from 0.1 mg/kg to 120 mg/kg, in particular from 10 mg/kg to 110 mg/kg of an antibiotic are co-administered together with meloxicam.
  • Amoxicillin 5 mg/kg to 30 mg/kg, in particular about 10 mg/kg
  • Oxytetracycline 20 mg/kg to 70 mg/kg, in particular about 30 mg/kg
  • Florfenicol 10 mg/kg to 20 mg/kg, in particular about 15 mg/kg
  • Tylosin 10 mg/kg to 25 mg/kg, in particular about 16 mg/kg
  • Tilmicosin 5 mg/kg to 30 mg/kg, in particular 10 mg/kg to 20 mg/kg
  • Sulfamethazine 80 mg/kg to 150 mg/kg, in particular about 100 mg/kg.
  • co-administration in defining use of meloxicam and an antibiotic, is intended to embrace administration of each agent in a sequential manner in a regimen that will provide beneficial effects, in particular, reduction of the symptoms of the respiratory disease in the affected pig of the drug combination.
  • the phrase also is intended to embrace co-administration of these agents in a substantially simultaneous manner, such as in a single capsule or injection solution having a fixed ratio of these active agents or in multiple, separate capsules for each agent.
  • meloxicam and the antibiotic may be co-administered in a combined form, or separately or separately and sequentially wherein the sequential administration is preferably close in time.
  • the medicament according to this invention is used for the prevention or treatment of Porcine Respiratory Disease Complex in growing or fattening pigs; or for the prevention or treatment of respiratory diseases in pigs caused by mycoplasmas, in particular Mycoplasma hyopneumoniae, Mycoplasma hyorhinis , for the prevention or treatment of respiratory diseases in pigs caused by bacteria in particular Actinobacillus spp., in particular Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Pasteurella multocida, Arcanobacterium pyogenes, Streptococcus spp., and Staphylococcus spp., or for the prevention or treatment of respiratory diseases in pigs caused by viruses, in particular Swine Influenza Virus, Aujetzky's Virus, Porcine Reproductive and Respiratory Syndrome Virus, Porcine Circovirus, and Transmissible Gastroenteritis and Porcine Respiratory Coronavirus.
  • the medicament according to this invention is used for the prevention or treatment of respiratory diseases in pigs caused by Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Pasteurella multocida, Streptococcus suis , Swine Influenza Virus, and Porcine Reproductive and Respiratory Syndrome Virus.
  • the study was a controlled, randomized, and blinded exploratory study under experimental conditions with a parallel group design.
  • Crossbred pigs of about 10 weeks of age were challenged with a single intranasal inoculation of Actinobacillus pleuropneumoniae . The next day, pigs were included in the study and treated if they fulfilled the following inclusion criteria: rectal temperature ⁇ 40° C. and clinical symptoms of acute or subacute infectious respiratory disease.
  • Meloxicam was administered as 0.5% solution, at 0.5 mg/kg daily on three consecutive days, oxytetracycline as 20% long-acting solution (OXYTET® 200) at 20 mg/kg as single injection.
  • the aim of this study was to test the efficacy of meloxicam granules dissolved in drinking water in pigs experimentally infected with Swine Influenza Virus (SIV).
  • the study was an open, negative controlled randomized laboratory study carried out according to GCP at one site.
  • the study animals were clinically examined daily on study days 0 to 7 and 14. They were weighed on study days 7 and 14. All animals of group A and 5 animals of group C were euthanized and necropsied on study day 7; the remaining study animals, group B and 5 study animals of group C, on study day 14.
  • FIG. 2 shows the quantity of lung lesions by lung lobe on study days 7 and 14.
  • meloxicam-treated pigs reached significantly higher weight gains during the two weeks following infection than untreated controls.
  • Mean daily weight gain in the interval study day 0 to 7 was 557 g in meloxicam group A and 257 g in the control (5 study animals of group C).
  • mean daily weight gain was 629 g in meloxicam group B and 486 g in the control (5 study animals of group C).
  • Growth performance data for each group included the Average Daily Gain (ADG) for the following trial periods: d90 to d117, d117 to d170 (slaughtering), and d90 to d170 of age. Mortality was also calculated for these time periods. Slaughterhouse records per group, included the percentage of each lung surface (LS) affected by chronic and acute respiratory lesions.
  • ADG Average Daily Gain
  • RS and AIM in the meloxicam group were significantly lower (p ⁇ 0.05) compared to the control group. Same applies for LS affected by acute lesions (p ⁇ 0.01), while no differences were observed for LS in chronic cases (Table 1).

Abstract

A method of treating or preventing a respiratory disease in a pig, the method comprising administering to the pig in need thereof an effective amount of meloxicam or a pharmaceutically acceptable salt thereof.

Description

    RELATED APPLICATIONS
  • This application is a continuation of U.S. application Ser. No. 11/047,920, filed Feb. 1, 2005, which is hereby incorporated by reference, and further claims priority to European Application No. EP 04 004 054.5, filed Feb. 23, 2004, which is hereby incorporated by reference.
  • BACKGROUND OF THE INVENTION
  • 1. Technical Field
  • The invention relates to the use of meloxicam or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment or prevention of respiratory diseases in pigs.
  • 2. Background Information
  • Respiratory disease in pigs belongs to the most important health problems in swine production. Porcine respiratory disease is primarily caused by infectious agents, but environmental factors have a strong influence. The relevant pathogens include mycoplasmas, bacteria, and viruses (e.g., G. Christensen, V. Sorensen, and J. Mousing, Diseases of the Respiratory System, In: Diseases of Swine, B. E. Straw, S. D'Allaire, W. L. Mengeling, & D. J. Taylor (eds), Iowa State University Press, Ames, Iowa (1999) pp. 913-940).
  • The most important measures for the control of porcine respiratory disease are to improve herd management and housing conditions and introduce a vaccination program. However, if pigs have developed respiratory disease, they have to be treated.
  • Current therapy of porcine respiratory disease includes treatment with antibiotics. The successful use of various types of antibiotics is described, including β-lactams, quinolones, and tetracyclines (e.g., 1. Lang, M. Rose, E. Thomas, & E. Zschiesche, A Field Study of Cefquinome for the Treatment of Pigs with Respiratory Disease, Revue Med Vet 8-9, (2002) pp. 575-580).
  • It is known that cyclooxygenase-2 (COX-2) plays a relevant role in the pathophysiology of porcine pleuropneumonia caused by Actinobacillus pleuropneumoniae. Isolated porcine alveolar macrophages increase their COX-2 activity after exposure to Actinobacillus pleuropneumoniae (W. S. Cho & C. Chae, In vitro Effects of Actinobacillus pleuropneumoniae on Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in Porcine Alveolar Macrophages, Am J Vet Res 64, (2003) pp. 1514-1518). Moreover, in situ hybridization (W. S. Cho & C. Chae, Expression of Cyclooxygenase-2 in Swine Naturally Infected with Actinobacillus pleuropneumoniae. Vet Pathol 40, (2003) pp. 25-31) and immunohistochemistry (W. S. Cho & C. Chae, Immunohistochemical Detection of Cyclooxygenase-2 in Lungs of Pigs Naturally Infected with Actinobacillus pleuropneumoniae, J Comp Pathol 127, (2002) pp. 274-279) showed increased COX-2 expression in lungs of pigs naturally infected with Actinobacillus pleuropneumoniae.
  • Moreover, it is well-known that acetylsalicylic acid (aspirin) can be used for the treatment of pigs with respiratory disease. However, little information on controlled clinical studies is available: for a review, see A. Laval, Utilisation des Anti-inflammatoires chez le Porc, Rec Méd Vét 168 (8/9) (1992) pp. 733-744. Ketoprofen, and, to a lesser extent, flunixin decrease fever induced by experimental infection with Actinobacillus pleuropneumoniae (J. M. Swinkels, A. Pijpers, J. C. Vernooy, A. Van Nes, & J. H. Verheijden, Effects of Ketoprofen and Flunixin in Pigs Experimentally Infected with Actinobacillus pleuropneumoniae, J Vet Pharmacol Ther 17, (1994) pp. 299-303). However, no effects on lung lesions were observed. Ketoprofen was further tested in a controlled, blinded clinical field study (M. F. De Jong, O, Sampimon, J. P. Arnaud, G. Theunissen, G. Groenland, & P. J. Werf, A Clinical Study with a Non Steroid Antiinflammatory Drug, 14, (1996) 659 IPVS). In this study, ketoprofen had no effect on clinical score, relapse, or cure rate.
  • Indomethacin alleviated experimental endotoxin-induced respiratory failure in pigs (N. C. Olson, T. T. Brown, J. R. Anderson, & D. L. Anderson, Dexamethasone and Indomethacin Modify Endotoxin-Induced Respiratory Failure in Pigs, J Appl Physiol 58, (1985) pp. 274-284).
  • Meloxicam is a non-steroidal anti-inflammatory compound that belongs to the oxicam class and exerts potent anti-inflammatory, anti-exudative, and anti-pyretic activity. The efficacy of meloxicam as an adjunctive therapy in the treatment of respiratory infections in cattle has been widely proven. Recently meloxicam was approved for the treatment of MMA (A. Hirsch et al., J Vet Pharmacol Therap 26 (2003) pp. 355-360) and locomotor disorders in pigs (G. Friton et al., Berl Münch Tierärztl Wschr 116 (2003) pp. 421-426).
  • A review article (P. Lees, The Pharmacokinetics of Drugs Used in the Treatment of Respiratory Diseases in Cattle and Pigs, (1991) pp. 67-74, Hatfield, U.K. Proc. Royal Vet. Coll.) focuses on pharmacokinetics used in the treatment of respiratory disease in cattle and pigs; however, non-steroidal anti-inflammatory drugs data for pigs was almost entirely lacking and only lists data for cattle including meloxicam.
  • The use of meloxicam in conjunction with antibiotics in bovine respiratory disease is well-established (H. Schmidt, H. Philipp, E. Salomon, & K. Okkinga, Effekte der zusätzlichen Gabe von Metacam (Meloxicam) auf den Krankheitsverlauf bei Rindern mit Atemwegserkrankungen, Der praktische Tierarzt 81 (2000) pp. 240-244) and registered in the EU. However, to date no information on the use of meloxicam in pigs with respiratory disease is publicly available.
  • Since the pharmacokinetics in pigs and cattle differ substantially for meloxicam (plasma half-time in cattle is 26 hours whereas it is 2.5 hours in pigs), there is no expectation that the successful use of meloxicam in cattle should also be beneficial for pigs. Moreover, the causative agents for bovine and porcine respiratory disease differ substantially.
  • The problem underlying the present invention was to provide a medication for the prevention or treatment of respiratory diseases in pigs, one of the most important health problems in swine production.
  • BRIEF DESCRIPTION OF THE INVENTION
  • It has been found surprisingly that meloxicam can be used for the treatment or prevention of respiratory diseases in pigs.
  • Accordingly, the invention relates to the use of meloxicam or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment or prevention of respiratory diseases in pigs.
  • Moreover, the invention relates to a method of treating or preventing respiratory diseases in pigs, which method comprises administering an effective amount of meloxicam to the pigs in need thereof.
  • Furthermore, the invention relates to veterinary preparation containing meloxicam as well as at least one antibiotic selected from the group consisting of β-lactams, quinolones, tetracyclines, sulfonamides, fenicoles, and macrolides.
  • Another aspect of the invention is a ready-to-use two-component system for the treatment of respiratory diseases in pigs, wherein:
      • (a) one component contains meloxicam and a pharmaceutically acceptable carrier; and
      • (b) the other component contains at least one antibiotic selected from the group consisting of β-lactams, quinolones, tetracyclines, sulfonamides, fenicoles, and macrolides and a pharmaceutically acceptable carrier.
  • Still another aspect of the invention is an article of manufacture comprising packaging material contained within which is a composition consisting of meloxicam and a pharmaceutically acceptable carrier, and a label which indicates that the composition can be used to treat or prevent respiratory diseases in pigs.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 shows the incidence of fever (rectal temperature≧40.56° C.) in percent following the first treatment in a group of pigs treated with oxytetracycline and meloxicam (♦), in a group of pigs treated with oxytetracycline alone (◯), and in the untreated control (Δ).
  • FIG. 2 shows the efficacy of meloxicam in drinking water in reducing lung lesions caused by experimental Swine Influenza Virus (SIV) infection on study days 7 and 14.
  • DETAILED DESCRIPTION OF THE INVENTION
  • Preferably the invention relates to the use of meloxicam or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition in a form suitable for systemic or oral administration for the treatment or prevention of respiratory diseases in pigs. Meloxicam (4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide) of formula
  • Figure US20080280840A1-20081113-C00001
  • is an active substance which belongs to the group of NSAIDs (non-steroidal-anti-inflammatory drugs). Meloxicam and the sodium and meglumine salt thereof (N-methyl-D-glucamine salt) are described in EP-A-0 002 482 (corresponding to U.S. Pat. No. 4,233,299), each of which is hereby incorporated by reference.
  • Meloxicam may be used according to the invention in the form of a physiologically acceptable acid addition salt. By physiologically acceptable acid addition salts are meant, according to the invention, the meglumine, sodium, potassium, or ammonium salt, preferably the meloxicam meglumine salt.
  • In a further preferred embodiment, the pharmaceutical composition is administered corresponding to a daily dose of meloxicam ranging from 0.01 mg/kg to 5.0 mg/kg, preferably from 0.1 mg/kg to 3.5 mg/kg, in particular from 0.2 mg/kg to 2.0 mg/kg.
  • The pharmaceutical composition is preferably administered in a form suitable for injection, in particular for intramuscular injection, or in form of water soluble granules for administration via drinking water or as top dressing on feed.
  • A suitable injection formulation is disclosed, for example, in Example 25 of EP-A-0 002 482. Furthermore, such injection solutions may additionally contain excipients selected from among citric acid, lecithin, gluconic acid, tartaric acid, phosphoric acid and EDTA or the salts thereof as disclosed in the Examples 1 to 5 of the International Patent Application WO 01/97813 (corresponding to U.S. Patent App. Pub No. 2002/0035107), each of which is hereby incorporated by reference. Moreover, an injection solution of meloxicam for needleless injections is disclosed in the International Patent Application WO 03/049733 (corresponding to U.S. Patent App. Pub No. 2003/0119825), each of which is hereby incorporated by reference.
  • Suitable water soluble granules for administration via drinking water or as top dressing on feed are, for example, disclosed in the International Patent Application PCT/EP03/11802 (corresponding to U.S. Patent App. Pub No. 2004/0234596), each of which is hereby incorporated by reference.
  • In a preferred embodiment of the invention, the meloxicam granules contain a binder which may be selected from among hydroxypropylmethylcellulose, polyvinylpyrrolidone, gelatine, starch, and polyethylene glycol ether, preferably hydroxypropylmethylcellulose, polyvinylpyrrolidone, and polyethylene glycol ether, and most preferably hydroxypropylmethylcellulose and polyvinylpyrrolidone.
  • In another preferred embodiment of the invention, meloxicam granules contain a sweetener, which may be selected from among sodium saccharine, aspartame, and SUNETT® (acesulfame K), preferably sodium saccharine or aspartame.
  • Particularly preferred according to the invention are meloxicam granules containing a flavoring agent which may be selected from among vanilla, honey flavoring, apple flavoring, and contramarum, preferably honey flavoring and apple flavoring.
  • Also particularly preferred are meloxicam granules in which the carrier is selected from among lactose, glucose, mannitol, xylitol, sucrose, and sorbitol, preferably glucose, lactose, or sorbitol, more preferably glucose or lactose, and most preferably glucose.
  • Most preferred are the following granules of meloxicam recipes:
  • EXAMPLE A 0.6% Meloxicam Granules
  • g/100 g
    Meloxicam 0.6
    Meglumine 0.42
    Hydroxypropylmethylcellulose 3.00
    Povidone 2.00
    Glucose monohydrate 93.98
  • EXAMPLE B 1.2% Meloxicam Granules
  • g/100 g
    Meloxicam 1.2
    Meglumine 0.84
    Hydroxypropylmethylcellulose 3.00
    Collidone 25 2.0
    Glucose Monohydrate 92.96
  • EXAMPLE C 0.6% Meloxicam Granules
  • g/100 g
    Meloxicam 0.6
    Meglumine 0.42
    Pharmacoat 606 4.0
    Macrogol 6000 1.0
    Acesulfame K 0.3
    Lactose 93.68
  • EXAMPLE D 0.6% Meloxicam Granules
  • g/100 g
    Meloxicam 0.6
    Meglumine 0.42
    Pharmacoat 606 4.75
    Macrogol 6000 0.25
    Acesulfame K 0.3
    Liquid vanilla flavoring 0.05
    Lactose 93.63
  • Particularly preferred are meloxicam granules in which the content of meloxicam is between 0.05% and 4%, preferably between 0.1% and 2%, preferably between 0.3% and 1.8%, more preferably between 0.4% and 1.5%, and most preferably 1.2%. Also particularly preferred are meloxicam granules which contain meglumine and meloxicam in a molar ratio of about 9:8 to 12:8, preferably 10:8.
  • Meloxicam can be used according to the invention to treat or prevent respiratory diseases in any breed of swines. Preferably pigs selected from the swine breeds American Landrace, American Yorkshire, Angeln Saddleback, Arapawa Island, Ba Xuyen, Bantu, Bazna, Beijing Black, Belarus Black Pied, Belgian Landrace, Bentheim Black Pied, Berkshire, Black Slavonian, British Landrace, British Lop, Bulgarian White, Cantonese, Chester White, Czech Improved White, Danish Landrace, Dermantsi Pied, Duroc, Dutch Landrace, Fengjing, Finnish Landrace, French Landrace, German Landrace, Gloucestershire Old Spots, Guinea Hog, Hampshire, Hereford, Hezuo, Iberian, Italian Landrace, Jinhua, Kele, Krskopolje, Kunekune, Lacombe, Large Black, Large Black-white, Large White, Lithuanian Native, Mangalitsa, Meishan, Middle White, Minzhu, Mong Cai, Mukota, Mora Romagnola, Moura, Mulefoot, Neijiang, Ningxiang, Norwegian Landrace, Ossabaw Island, Oxford Sandy and Black, Philippine Native, Pietrain, Poland China, Red Wattle, Saddleback, Spots, Swabian-Hall, Swedish Landrace, Tamworth, Thuoc Nhieu, Tibetan, Turopolje, Vietnamese Potbelly, Welsh, and Wuzhishan, in particular American Landrace, Belgian Landrace, British Landrace, Danish Landrace, Dutch Landrace Finnish Landrace, French Landrace, German Landrace, Italian Landrace, and Pietrain can be treated with meloxicam according to the present invention.
  • Furthermore preferred is the administration of meloxicam is in conjunction with an antibiotic, preferably selected from the group consisting of β-lactams, quinolones, tetracyclines, sulfonamides, fenicoles, and macrolides. Most preferred are amoxicillin, oxytetracycline, florfenicol, tylosin, tilmicosin, and sulfamethazine.
  • The dose of antibiotic is not critical per se and depends strongly on the different efficacies of the antibiotics used. As a rule up to 150.0 mg/kg, preferably from 0.1 mg/kg to 120 mg/kg, in particular from 10 mg/kg to 110 mg/kg of an antibiotic are co-administered together with meloxicam.
  • The following dose ranges are most preferred:
  • Amoxicillin: 5 mg/kg to 30 mg/kg, in particular about 10 mg/kg;
    Oxytetracycline: 20 mg/kg to 70 mg/kg, in particular about 30 mg/kg;
    Florfenicol: 10 mg/kg to 20 mg/kg, in particular about 15 mg/kg;
    Tylosin: 10 mg/kg to 25 mg/kg, in particular about 16 mg/kg;
    Tilmicosin: 5 mg/kg to 30 mg/kg, in particular 10 mg/kg to
    20 mg/kg; and
    Sulfamethazine: 80 mg/kg to 150 mg/kg, in particular about 100 mg/kg.
  • The phrase “co-administration” (or “administration in conjunction with”), in defining use of meloxicam and an antibiotic, is intended to embrace administration of each agent in a sequential manner in a regimen that will provide beneficial effects, in particular, reduction of the symptoms of the respiratory disease in the affected pig of the drug combination. The phrase also is intended to embrace co-administration of these agents in a substantially simultaneous manner, such as in a single capsule or injection solution having a fixed ratio of these active agents or in multiple, separate capsules for each agent.
  • Accordingly, meloxicam and the antibiotic may be co-administered in a combined form, or separately or separately and sequentially wherein the sequential administration is preferably close in time.
  • Preferably the medicament according to this invention is used for the prevention or treatment of Porcine Respiratory Disease Complex in growing or fattening pigs; or for the prevention or treatment of respiratory diseases in pigs caused by mycoplasmas, in particular Mycoplasma hyopneumoniae, Mycoplasma hyorhinis, for the prevention or treatment of respiratory diseases in pigs caused by bacteria in particular Actinobacillus spp., in particular Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Pasteurella multocida, Arcanobacterium pyogenes, Streptococcus spp., and Staphylococcus spp., or for the prevention or treatment of respiratory diseases in pigs caused by viruses, in particular Swine Influenza Virus, Aujetzky's Virus, Porcine Reproductive and Respiratory Syndrome Virus, Porcine Circovirus, and Transmissible Gastroenteritis and Porcine Respiratory Coronavirus.
  • Most preferably the medicament according to this invention is used for the prevention or treatment of respiratory diseases in pigs caused by Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Pasteurella multocida, Streptococcus suis, Swine Influenza Virus, and Porcine Reproductive and Respiratory Syndrome Virus.
  • The Examples that follow serve to illustrate the use of meloxicam according to the invention. They are intended solely as possible procedures described by way of example, without restricting the invention to their content.
  • EXAMPLE 1 Efficacy of Meloxicam in Pigs with Experimental Actinobacillus Pleuropneumoniae Infection
  • The study was a controlled, randomized, and blinded exploratory study under experimental conditions with a parallel group design.
  • Crossbred pigs of about 10 weeks of age were challenged with a single intranasal inoculation of Actinobacillus pleuropneumoniae. The next day, pigs were included in the study and treated if they fulfilled the following inclusion criteria: rectal temperature≧40° C. and clinical symptoms of acute or subacute infectious respiratory disease.
  • Twenty-four (12 castrated male and 12 female) pigs were included and randomly allocated to three treatment groups with 8 pigs per group. The treatment groups were:
  • Group Treatment
    1 untreated
    2 oxytetracycline
    3 oxytetracycline and meloxicam
  • Meloxicam was administered as 0.5% solution, at 0.5 mg/kg daily on three consecutive days, oxytetracycline as 20% long-acting solution (OXYTET® 200) at 20 mg/kg as single injection.
  • Relevant criteria for the evaluation of efficacy were incidence of fever, clinical parameters of respiratory disease, deaths, and lung lesions at necropsy 10 days after first treatment or after spontaneous death. The percentage of affected lung tissue was calculated by lobe and averaged for the total lung.
  • Challenge with Actinobacillus pleuropneumoniae lead to severe pleuropneumonia within 12 hours.
  • The incidence of fever (rectal temperature≧40.56° C.) following the first treatment was lower in group 3 (♦) than in groups 1 (Δ), and 2 (◯) (cp. FIG. 1).
  • The best treatment response in clinical parameters was observed in group 3.
  • The number of pigs which died during the three days following first treatment is displayed below.
  • Group (n = 8 per group) Deaths
    1 7
    2 1
    3 0
  • The mean extent of lung lesions was less severe in group 3 than in the other groups (see below).
  • Group Lung lesions (%)
    1 60
    2 35
    3 14
  • Meloxicam in addition to antibiotic treatment effectively reduced fever, clinical symptoms of respiratory disease, deaths, and the extent of lung lesions in pigs with experimental Actinobacillus pleuropneumoniae-infection.
  • EXAMPLE 2 Efficacy of Meloxicam in Drinking Water in Experimental Swine Influenza Virus Infection
  • The aim of this study was to test the efficacy of meloxicam granules dissolved in drinking water in pigs experimentally infected with Swine Influenza Virus (SIV).
  • The study was an open, negative controlled randomized laboratory study carried out according to GCP at one site.
  • Meloxicam granules containing 6 mg meloxicam per gram were offered to the pigs in the treatment groups (A+B) via drinking water in a concentration of 1 g granules per liter drinking water ad libitum for 7 consecutive days. This resulted in an actual meloxicam uptake of 0.8 mg per kg body weight per day. The pigs in the control group (C) received municipal drinking water ad libitum.
  • 30 pigs were infected with SIV on study day 0.10 pigs were allocated to each of the three groups A, B, and C. Treatment (groups A and B) started after SIV challenge on the same day.
  • The study animals were clinically examined daily on study days 0 to 7 and 14. They were weighed on study days 7 and 14. All animals of group A and 5 animals of group C were euthanized and necropsied on study day 7; the remaining study animals, group B and 5 study animals of group C, on study day 14.
  • It is the major finding of this study that meloxicam granules administered continuously in the drinking water at an approximate daily dose of 0.8 mg/kg body weight significantly alleviated the development of lung lesions caused by experimental infection with SIV during the first week after challenge. FIG. 2 shows the quantity of lung lesions by lung lobe on study days 7 and 14.
  • On study day 7 the percentage of lung tissue affected with SIV-related lesions (median value) was 8.9% in meloxicam group A and 23.8% in the control group (5 study animals of group C).
  • Moreover, meloxicam-treated pigs reached significantly higher weight gains during the two weeks following infection than untreated controls. Mean daily weight gain in the interval study day 0 to 7 was 557 g in meloxicam group A and 257 g in the control (5 study animals of group C). In the interval study day 0 to 14, mean daily weight gain was 629 g in meloxicam group B and 486 g in the control (5 study animals of group C).
  • The area under the curve of the clinical index score (CIS), a sum of the relevant clinical parameters, over study days 0 to 7 was significantly smaller in groups A and B than in group C.
  • Thus oral treatment with meloxicam granules at a dose of 0.8 mg meloxicam per kg body weight per day for 7 consecutive was an efficacious treatment for SIV infection.
  • EXAMPLE 3 Field Trial Regarding the Effect of Meloxicam in the Porcine Respiratory Disease Complex (PRDC) in Growing/Fattening Pigs Materials and Methods
  • A medium scale farm (560 sows) with a previous history of recurring PRDC episodes was selected. A double-blinded randomized study was carried out with the selection of 162 growing animals with a mean age of 90 days at the onset of PRDC clinical signs. Animals were randomly allocated to 8 pens and divided into two treatment groups, with respect to equal sex ratio, same housing and feeding conditions and genetic background. Group 1 (PC) received 800 ppm chlorotetracycline in the feed over 8 consecutive days plus a single IM injection of a placebo (isotonic saline) at d0 (start of the trial, n=82). Group 2 (M) received 800 ppm chlorotetracycline in the teed over 8 consecutive days plus a single IM injection of 0.4 mg/kg bodyweight meloxicam (METACAM® 2%, Boehringer Ingelheim GmbH) at d0 (n=80). Clinical parameters were assessed as the daily Respiratory Score (RS), using a 3 point score (0=absence of signs to 3=abdominal breathing and disordered general condition) over 8 consecutive days and the total number of additional required injectable medications (AIM). Growth performance data for each group included the Average Daily Gain (ADG) for the following trial periods: d90 to d117, d117 to d170 (slaughtering), and d90 to d170 of age. Mortality was also calculated for these time periods. Slaughterhouse records per group, included the percentage of each lung surface (LS) affected by chronic and acute respiratory lesions.
  • Student's t-Test and Pearson's Chi-Square Test were used for the consequent comparisons of means and frequencies between trial groups.
  • Results and Discussion
  • RS and AIM in the meloxicam group were significantly lower (p<0.05) compared to the control group. Same applies for LS affected by acute lesions (p<0.01), while no differences were observed for LS in chronic cases (Table 1).
  • TABLE 1
    RS, LS: Mean (SD); AIM number (%)
    Treatment Group
    PC M Significance
    RS  0.70 (0.63)a 0.50 (0.51)b p = 0.0289
    AIM (%) 10/82 (12.2%)a 2/80 (2.5%)b x2 = 4.226
    LS(chronic)  5.96 (2.28)a 5.91 (2.32)a p = 0.893
    LS (acute)  3.71 (1.81)a 2.64 (2.03)b p = 0.0007
    a,bValues in a row with different superscripts differ significantly
  • The analysis of growth performance data revealed significant differences between groups at d90 to d117 (p<0.05, Table 2).
  • TABLE 2
    ADG: Mean (SD)
    Trial Period
    Group d90 to d117 d117 to d170 d90 to d170
    PC 0.64 (0.09)a 0.89 (0.06)a 0.81 (0.03)a
    M 0.67 (0.10)b 0.89 (0.06)a 0.82 (0.03)a
    a,bValues in a column with different superscripts differ significantly (p < 0.05)
  • TABLE 3
    Mortality: Number of animals/group (%)
    Trial Period
    Group d90 to d117 d117 to d170 d90 to d170
    PC 6/82 (7.32%)a 1/76 (1.22%) 7/82 (8.54%)
    M 0/80 (0.00%)b 1/80 (1.25%) 1/80 (1.25%)
    a,bValues in a column with different superscripts differ significantly (p < 0.05)
  • Under the conditions of this study, the reduction of the prevalence of respiratory signs as well as the reduced overall number of required injectable antibiotic medications are indicative for the potent anti-inflammatory activity of meloxicam. The latter could become a valuable adjunctive measure, especially when respiratory distress is associated with remarkable reduction of the feed intake. The initial differences in growth performance and in mortality rate could be explained by the fact that meloxicam, when combined with proper antimicrobial medication, contributes to faster recovery from a respiratory inflammation and faster restoring of the distorted growth rate of affected animals. Further research on the evaluation of feed intake and the use of meloxicam in PRDC recurring episodes is required.

Claims (22)

1. A method of treating or preventing a respiratory disease in a pig, the method comprising administering to the pig in need thereof an effective amount of the pharmaceutical composition of claim 23.
2. The method according to claim 1, wherein said pharmaceutical composition is administered systemically or orally.
3. The method according to claim 1, wherein said pharmaceutical composition is administered in a daily dose ranging from 0.01 mg/kg to 5.0 mg/kg.
4. The method according to claim 2, wherein said pharmaceutical composition is administered in a daily dose ranging from 0.01 mg/kg to 5.0 mg/kg.
5. The method according to claim 1, wherein said pharmaceutical composition is administered by injection.
6. The method according to claim 2, wherein said pharmaceutical composition is administered by injection.
7. The method according to claim 1, wherein said pharmaceutical composition is administered via drinking water or as top dressing on feed in soluble granules.
8. The method according to claim 2, wherein said pharmaceutical composition is administered via drinking water or as top dressing on feed in soluble granules.
9-10. (canceled)
11. The method according to claim 1, wherein the antibiotic in the pharmaceutical composition of claim 23 is selected from the group consisting of β-lactams, quinolones, tetracyclines, sulfonamides, fenicoles, and macrolides.
12. The method according to claim 2, wherein the antibiotic in said pharmaceutical composition of claim 23 is selected from the group consisting of β-lactams, quinolones, tetracyclines, sulfonamides, fenicoles, and macrolides.
13. The method according to claim 1, wherein the antibiotic in said pharmaceutical composition of claim 23 is oxytetracycline or chlorotetracycline.
14. The method according to claim 2, wherein the antibiotic in said pharmaceutical composition of claim 23 is oxytetracycline or chlorotetracycline.
15. The method according to claim 1, wherein the disease is Porcine Respiratory Disease Complex and the pig is a growing or fattening pig.
16. The method according to claim 2, wherein the disease is Porcine Respiratory Disease Complex and the pig is a growing or fattening pig.
17. The method according to claim 1, wherein the disease is caused by mycoplasmas, bacteria, or viruses.
18. The method according to claim 2, wherein the disease is caused by mycoplasmas, bacteria, or viruses.
19. The method according to claim 1, wherein the disease is caused by Mycoplasma hyopneumoniae, Mycoplasma hyorhinis, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Pasteurella multocida, Arcanobacterium pyogenes, Swine Influenza Virus, Aujetzky's Virus, Porcine Reproductive and Respiratory Syndrome Virus, Porcine Circovirus, and Transmissible Gastroenteritis and Porcine Respiratory Coronavirus.
20. The method according to claim 2, wherein the disease is caused by Mycoplasma hyopneumoniae, Mycoplasma hyorhinis, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Pasteurella multocida, Arcanobacterium pyogenes, Swine Influenza Virus, Aujetzky's Virus, Porcine Reproductive and Respiratory Syndrome Virus, Porcine Circovirus, and Transmissible Gastroenteritis and Porcine Respiratory Coronavirus.
21. The method according to claim 1, wherein the disease is caused by Actinobacillus spp., Streptococcus spp., or Staphylococcus spp.
22. The method according to claim 2, wherein the disease is caused by Actinobacillus spp., Streptococcus spp., or Staphylococcus spp.
23. A ready-to-use two-component pharmaceutical composition for the treatment of respiratory diseases in pigs, the composition comprising:
(a) a first component comprising meloxicam or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier; and
(b) a second component comprising one or more antibiotics selected from the group consisting of β-lactams, quinolones, tetracyclines, sulfonamides, fenicoles, and macrolides, and a pharmaceutically acceptable carrier.
US12/114,509 2004-02-23 2008-05-02 Meloxicam for the treatment of respiratory diseases in pigs Abandoned US20080280840A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US12/114,509 US20080280840A1 (en) 2004-02-23 2008-05-02 Meloxicam for the treatment of respiratory diseases in pigs
US14/183,744 US20140179639A1 (en) 2004-02-23 2014-02-19 Meloxicam for the treatment of respiratory diseases in pigs
US15/908,470 US10548901B2 (en) 2004-02-23 2018-02-28 Meloxicam for the treatment of respiratory diseases in pigs
US16/719,681 US11083731B2 (en) 2004-02-23 2019-12-18 Meloxicam for the treatment of respiratory diseases in pigs

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EPEP04004054.5 2004-02-23
EP04004054A EP1568369A1 (en) 2004-02-23 2004-02-23 Use of meloxicam for the treatment of respiratory diseases in pigs
US11/047,920 US20050187213A1 (en) 2004-02-23 2005-02-01 Meloxicam for the treatment of respiratory diseases in pigs
US12/114,509 US20080280840A1 (en) 2004-02-23 2008-05-02 Meloxicam for the treatment of respiratory diseases in pigs

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US11/047,920 Continuation US20050187213A1 (en) 2004-02-23 2005-02-01 Meloxicam for the treatment of respiratory diseases in pigs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/183,744 Division US20140179639A1 (en) 2004-02-23 2014-02-19 Meloxicam for the treatment of respiratory diseases in pigs

Publications (1)

Publication Number Publication Date
US20080280840A1 true US20080280840A1 (en) 2008-11-13

Family

ID=34745861

Family Applications (5)

Application Number Title Priority Date Filing Date
US11/047,920 Abandoned US20050187213A1 (en) 2004-02-23 2005-02-01 Meloxicam for the treatment of respiratory diseases in pigs
US12/114,509 Abandoned US20080280840A1 (en) 2004-02-23 2008-05-02 Meloxicam for the treatment of respiratory diseases in pigs
US14/183,744 Abandoned US20140179639A1 (en) 2004-02-23 2014-02-19 Meloxicam for the treatment of respiratory diseases in pigs
US15/908,470 Active US10548901B2 (en) 2004-02-23 2018-02-28 Meloxicam for the treatment of respiratory diseases in pigs
US16/719,681 Active US11083731B2 (en) 2004-02-23 2019-12-18 Meloxicam for the treatment of respiratory diseases in pigs

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US11/047,920 Abandoned US20050187213A1 (en) 2004-02-23 2005-02-01 Meloxicam for the treatment of respiratory diseases in pigs

Family Applications After (3)

Application Number Title Priority Date Filing Date
US14/183,744 Abandoned US20140179639A1 (en) 2004-02-23 2014-02-19 Meloxicam for the treatment of respiratory diseases in pigs
US15/908,470 Active US10548901B2 (en) 2004-02-23 2018-02-28 Meloxicam for the treatment of respiratory diseases in pigs
US16/719,681 Active US11083731B2 (en) 2004-02-23 2019-12-18 Meloxicam for the treatment of respiratory diseases in pigs

Country Status (16)

Country Link
US (5) US20050187213A1 (en)
EP (2) EP1568369A1 (en)
JP (1) JP5009147B2 (en)
KR (1) KR101233359B1 (en)
CN (1) CN1921865B (en)
AU (1) AU2005215122B2 (en)
BR (1) BRPI0507966A (en)
CA (1) CA2554040C (en)
DK (1) DK1720554T3 (en)
ES (1) ES2394038T3 (en)
MX (1) MXPA06009575A (en)
RU (1) RU2360680C2 (en)
SG (1) SG150531A1 (en)
TW (1) TW200533362A (en)
UA (1) UA92584C2 (en)
WO (1) WO2005079806A1 (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040180092A1 (en) * 2002-10-25 2004-09-16 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
US20050245510A1 (en) * 2004-04-29 2005-11-03 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam formulations in veterinary medicine
US20050288280A1 (en) * 2004-06-23 2005-12-29 Boehringer Ingelheim Vetmedica Gmbh Meloxicam in veterinary medicine
US20060079516A1 (en) * 2000-06-20 2006-04-13 Boehringer Ingelheim Vetmedica Gmbh Highly concentrated stable meloxicam solutions
US20070077296A1 (en) * 2005-09-30 2007-04-05 Folger Martin A Pharmaceutical Preparation containing Meloxicam
US20080132493A1 (en) * 2001-12-12 2008-06-05 Martin Andreas Folger Highly concentrated stable meloxicam solutions for needleless injection
US20110083985A1 (en) * 2009-10-12 2011-04-14 Boehringer Ingelheim Vetmedica Gmbh Containers for compositions comprising meloxicam
US9149480B2 (en) 2010-03-03 2015-10-06 Boehringer Ingeleheim Vetmedica GmbH Use of meloxicam for the long-term treatment of musculoskeletal disorders in cats
US9795568B2 (en) 2010-05-05 2017-10-24 Boehringer Ingelheim Vetmedica Gmbh Low concentration meloxicam tablets
US10548901B2 (en) 2004-02-23 2020-02-04 Boehringer Ingelheim Vetmedica Gmbh Meloxicam for the treatment of respiratory diseases in pigs

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100643222B1 (en) 2005-09-01 2006-11-10 빙빙투기술 주식회사 Therapeutic compostion for postweaning multisystemic wasting syndrome
EP1870102A1 (en) * 2006-06-15 2007-12-26 Alpex Pharma SA Solid forms containing meloxicam with improved taste and process for their preparation
US8097419B2 (en) * 2006-09-12 2012-01-17 Longhorn Vaccines & Diagnostics Llc Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009
US9481912B2 (en) 2006-09-12 2016-11-01 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and identifying nucleic acid sequences in biological samples
US20090098527A1 (en) * 2006-09-12 2009-04-16 Fischer Gerald W Biological organism identification product and methods
US8080645B2 (en) 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
US8652782B2 (en) 2006-09-12 2014-02-18 Longhorn Vaccines & Diagnostics, Llc Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids
KR100870077B1 (en) 2006-10-27 2008-11-25 권영득 Pharmaceutical formulation in the treatment of PMWS
BRPI0700969A (en) * 2007-03-22 2008-11-04 Ouro Fino Participacoes E Empr composition for the treatment of bacterial and inflammatory conditions in pet animals
US9683256B2 (en) 2007-10-01 2017-06-20 Longhorn Vaccines And Diagnostics, Llc Biological specimen collection and transport system
US11041215B2 (en) 2007-08-24 2021-06-22 Longhorn Vaccines And Diagnostics, Llc PCR ready compositions and methods for detecting and identifying nucleic acid sequences
RU2468034C2 (en) 2007-08-27 2012-11-27 ЛОНГХОРН ВЭКСИНС ЭНД ДИАГНОСТИКС ЭлЭлСи Immunogenic compositions and methods
US10004799B2 (en) 2007-08-27 2018-06-26 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
AU2008343745B2 (en) 2007-10-01 2012-05-10 Longhorn Vaccines & Diagnostics Llc Biological specimen collection and transport system and methods of use
US11041216B2 (en) 2007-10-01 2021-06-22 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples
US20110092454A1 (en) * 2009-09-30 2011-04-21 Dean Rimoldi Methods For Treating Mycoplasma Related Conditions In Livestock
US8791105B2 (en) 2010-07-14 2014-07-29 Kansas State University Research Foundation Methods for alleviating chronic pain and improving performance of cattle undergoing dehorning or castration
EP3494989A1 (en) 2012-01-26 2019-06-12 Longhorn Vaccines and Diagnostics, LLC Composite antigenic sequences and vaccines
GB2520065A (en) * 2013-11-08 2015-05-13 Norbrook Lab Ltd Tulathromycin and nonsteroidal anti-inflammatory drug compositions
EP2995297A1 (en) * 2014-09-09 2016-03-16 Ceva Sante Animale Parenteral compositions and uses thereof
US9976136B2 (en) 2015-05-14 2018-05-22 Longhorn Vaccines And Diagnostics, Llc Rapid methods for the extraction of nucleic acids from biological samples
AU2018302656A1 (en) * 2017-07-20 2020-01-16 Fuso Pharmaceutical Industries,Ltd. Combination use of inhibitor targeting PD-1/PD-L1 and COX-2 inhibitor
EP4098265A4 (en) * 2020-01-30 2024-03-13 Shenyang Fuyang Pharmaceutical Tech Co Ltd Use of acylated spiramycin in preparation of medicament for treating coronavirus infectious disease

Citations (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2795529A (en) * 1954-06-17 1957-06-11 American Home Prod Stabilized hyaluronidase solution containing calcium chloride
US3288675A (en) * 1964-03-20 1966-11-29 Hoffmann La Roche Parenteral sulfonamide compositions and processes
US3849549A (en) * 1971-10-06 1974-11-19 Merck & Co Inc Indomethacin suppositories
US3931212A (en) * 1973-07-19 1976-01-06 Warner-Lambert Company Method for treating cardiovascular circulatory insufficiencies and hypotonia with 2-hydroxy-phenyl-1-oxa-4-azaspiroalkane derivatives
US3947576A (en) * 1973-09-27 1976-03-30 Mortell Company Synergistic biostatic composition
US4233299A (en) * 1977-12-16 1980-11-11 Boehringer Ingelheim Gmbh 4-Hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides and salts thereof
US4482554A (en) * 1982-05-08 1984-11-13 Warner-Lambert Company Pharmaceutical compositions containing oxicam derivatives and process for their preparation
US4543200A (en) * 1983-09-28 1985-09-24 Sherman Laboratories, Inc. Contact lens preservative system cleaner and method
US4628053A (en) * 1984-10-10 1986-12-09 Heinrich Mack Nachf. Stabilized injectable solutions of piroxicam
US4748174A (en) * 1986-01-03 1988-05-31 Therapicon S.R.L. Water soluble salts of an NSAID with meglumine/glucamine
US4794117A (en) * 1984-03-03 1988-12-27 Jerome Corbiere Process for solubilizing active ingredients and the thus-obtained pharmaceutical compositions
US4802926A (en) * 1986-03-21 1989-02-07 Dmv-Campina B.V. Spray dried lactose and process for preparing the same
US4835187A (en) * 1987-06-15 1989-05-30 American Home Products Corporation Spray dried ibuprofen
US4942167A (en) * 1988-04-01 1990-07-17 Chiesi Farmaceutici S.P.A. Pharmaceutical compositions of piroxicam in aqueous solutions and process for their preparation
US5169847A (en) * 1990-11-27 1992-12-08 Egis Gyogyszergyar Drug solutions of increased stability and without tissue-damaging effect and process for preparing same
US5283065A (en) * 1989-09-21 1994-02-01 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
US5304561A (en) * 1992-07-24 1994-04-19 Faezeh Sarfarazi New concept in glaucoma treatment
US5360611A (en) * 1988-10-03 1994-11-01 Alcon Laboratories, Inc. Pharmaceutical compositions and methods of treatment of the cornea following ultraviolet laser irradiation
US5380934A (en) * 1992-10-29 1995-01-10 Kyowa Hakko Kogyo Co., Ltd. Process for producing alanylgutamine
US5414011A (en) * 1987-09-11 1995-05-09 Syntex (U.S.A.) Inc. Preservative system for ophthalmic formulations
US5654003A (en) * 1992-03-05 1997-08-05 Fuisz Technologies Ltd. Process and apparatus for making tablets and tablets made therefrom
US5700816A (en) * 1995-06-12 1997-12-23 Isakson; Peter C. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
US5811446A (en) * 1997-04-18 1998-09-22 Cytos Pharmaceuticals Llc Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor
US5824658A (en) * 1990-09-18 1998-10-20 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5886030A (en) * 1994-05-06 1999-03-23 Alcon Laboratories, Inc. Use of vitamin E tocopheryl derivatives in ophthalmic compositions
US5962012A (en) * 1997-11-28 1999-10-05 Caleb Pharmaceuticals, Inc. Cholinergic antagonist patch
US6046191A (en) * 1997-10-10 2000-04-04 Astra Pharmaceuticals Ltd. Combination
US6071539A (en) * 1996-09-20 2000-06-06 Ethypharm, Sa Effervescent granules and methods for their preparation
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6106862A (en) * 1998-08-13 2000-08-22 Andrx Corporation Once daily analgesic tablet
US6136804A (en) * 1998-03-13 2000-10-24 Merck & Co., Inc. Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions
US6156349A (en) * 1998-12-14 2000-12-05 Steinbach, Pylant And Herman, L.L.C. Method of treating HIV infection with suppository containing mammalian liver extract
US6166012A (en) * 1999-07-30 2000-12-26 Allergan Sales, Inc. Antibiotic compositions and method for using same
US6180136B1 (en) * 1998-11-10 2001-01-30 Idexx Laboratories, Inc. Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use
US6183779B1 (en) * 1999-03-22 2001-02-06 Pharmascience Inc. Stabilized pharmaceutical composition of a nonsteroidal anti-inflammatory agent and a prostaglandin
US6184220B1 (en) * 1998-03-27 2001-02-06 Boehringer Ingelheim Pharma Kg Oral suspension of pharmaceutical substance
US6187800B1 (en) * 1996-06-20 2001-02-13 Novartis Animal Health U.S., Inc. Method for the prevention and treatment of mastitis
US6221377B1 (en) * 1995-11-13 2001-04-24 Pitmy International N.V. Administration media for analgesic, anti-inflammatory and anti-pyretic drugs containing nitrous oxide and pharmaceutical compositions containing such media and drugs
US6284269B1 (en) * 1997-08-27 2001-09-04 Hexal Ag Pharmaceutical compositions of meloxicam with improved solubility and bioavailability
US6319519B2 (en) * 1998-07-07 2001-11-20 Norton Healthcare Ltd. Anti-inflammatory pharmaceutical formulations
US20020006440A1 (en) * 2000-07-05 2002-01-17 Cherukuri Subraman Rao Rapid-melt semi-solid compositions, methods of making same and methods of using same
US20020016342A1 (en) * 2000-05-15 2002-02-07 Edward Scolnick Combination therapy using COX-2 selective inhibitor and thromboxane inhibitor and compositions therefor
US20020035107A1 (en) * 2000-06-20 2002-03-21 Stefan Henke Highly concentrated stable meloxicam solutions
US20020068088A1 (en) * 1996-08-15 2002-06-06 Peter Gruber Easy to swallow oral medicament composition
US20020077328A1 (en) * 2000-07-13 2002-06-20 Fred Hassan Selective cyclooxygenase-2 inhibitors and vasomodulator compounds for generalized pain and headache pain
US20020099049A1 (en) * 1997-09-17 2002-07-25 Burch Ronald M. Analgesic combination of oxycodone and meloxicam
US20020106345A1 (en) * 1999-12-07 2002-08-08 Uhrich Kathryn E. Therapeutic compositions and methods
US20020187187A1 (en) * 2001-04-21 2002-12-12 Toshimitsu Ohki Fast disintegrating meloxicam tablet
US6495603B1 (en) * 1998-05-15 2002-12-17 Wakamoto Pharmaceutical Co., Ltd. Anti-inflammatory eye drop
US20030050305A1 (en) * 2000-05-22 2003-03-13 Tejada Inigo Saenz De Thromboxane inhibitors, compositions and methods of use
US20030055051A1 (en) * 1999-11-24 2003-03-20 Wakamoto Pharmaceutical Co., Ltd. Ophthalmic aqueous pharmaceutical preparation
US6550955B2 (en) * 2000-05-03 2003-04-22 D'silva Joe Process for producing liquid dosage formulations of medicinal compounds on demand from tablets and capsules using a mixing cup with an abrasive interior surface
US20030109701A1 (en) * 2001-12-11 2003-06-12 Laura Coppi Crystalline forms of meloxicam and processes for their preparation and interconversion
US20030119825A1 (en) * 2001-12-12 2003-06-26 Boehringer Ingelheim Vetmedica Gmbh Highly concentrated stable meloxicam solutions for needleless injection
US6599529B1 (en) * 1997-09-11 2003-07-29 Nycomed Danmark A/S Modified release multiple-units compositions of non-steroid anti-inflammatory drug substances (NSAIDs)
US6605295B1 (en) * 1997-07-11 2003-08-12 Bausch & Lomb Incorporated Storage-stable ophthalmic compositions comprising diclofenac and ofloxacin
US6630056B1 (en) * 1997-07-10 2003-10-07 Thibierge & Comar Color tracing paper
US20030199482A1 (en) * 2001-03-28 2003-10-23 Pharmacia Corporation Therapeutic combinations for cardiovascular and inflammatory indications
US20030220306A1 (en) * 2001-09-28 2003-11-27 Daniel Simmons Novel cyclooxygenase variants and methods of use
US6669957B1 (en) * 1999-09-15 2003-12-30 Cll Pharma Galenic formulations fast disintegrating in the mouth and method for preparing same
US20040001883A1 (en) * 2002-03-30 2004-01-01 Boehringer Ingelheim International Gmbh Meloxicam suppositories
US20040024041A1 (en) * 2000-07-01 2004-02-05 Torsten Selzer Dermal therapeutic system containing non-steroidal antiphlogistics with selective cox-2 inhibition
US20040024042A1 (en) * 2002-04-02 2004-02-05 Vanderbilt University COX2 inhibition in the prevention and treatment of autosomal dominant polycystic kidney disease
US20040037869A1 (en) * 2002-08-16 2004-02-26 Douglas Cleverly Non-animal product containing veterinary formulations
US20040043992A1 (en) * 2002-05-22 2004-03-04 Boehringer Ingelheim International Gmbh Meloxicam for alleviating organ injury during organ operation or transplantation
US20040110747A1 (en) * 2002-12-06 2004-06-10 Boehringer Ingelheim International Gmbh Use of meloxicam in combination with an antiplatelet agent for treatment of acute coronary syndrome and related conditions
US20040171611A1 (en) * 2002-09-30 2004-09-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline acetic acid solvate of meloxicam
US20040180092A1 (en) * 2002-10-25 2004-09-16 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
US20040198826A1 (en) * 2003-04-07 2004-10-07 Boehringer Ingelheim International Gmbh Pharmaceutical combination for treating benign prostatic hyperplasia or for treating abacterial prostatitis
US20040204472A1 (en) * 2003-03-04 2004-10-14 Pharmacia Corporation Treatment and prevention of obesity with COX-2 inhibitors alone or in combination with weight-loss agents
US20040204413A1 (en) * 2001-01-26 2004-10-14 Joaquina Faour Pharmaceutical compositions containing a COX-II inhibitor and a muscle relaxant
US20040214753A1 (en) * 2003-03-20 2004-10-28 Britten Nancy Jean Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
US20040229038A1 (en) * 2003-03-03 2004-11-18 Elan Pharma International Ltd. Nanoparticulate meloxicam formulations
US20040253312A1 (en) * 2001-09-28 2004-12-16 Sowden Harry S. Immediate release dosage form comprising shell having openings therein
US20050038018A1 (en) * 2003-07-09 2005-02-17 Boehringer Ingelheim International Gmbh Meloxicam compositions
US6869948B1 (en) * 1998-03-27 2005-03-22 Boehringer Ingelheim Pharma Kg Meloxicam for oral administration
US20050147664A1 (en) * 2003-11-13 2005-07-07 Elan Pharma International Ltd. Compositions comprising antibodies and methods of using the same for targeting nanoparticulate active agent delivery
US20050187213A1 (en) * 2004-02-23 2005-08-25 Boehringer Ingelheim Vetmedica Gmbh Meloxicam for the treatment of respiratory diseases in pigs
US20050187212A1 (en) * 2002-09-17 2005-08-25 Nippon Boehringer Ingelheim Co., Ltd. Pharmaceutical composition for topical delivery of meloxicam
US20050197332A1 (en) * 2002-12-10 2005-09-08 Boehringer Ingelheim International Use of meloxicam in combination with an antiplatelet agent for treatment of acute coronary syndrome and related conditions
US20050245510A1 (en) * 2004-04-29 2005-11-03 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam formulations in veterinary medicine
US20050277634A1 (en) * 2004-05-19 2005-12-15 Boehringer Ingelheim Vetmedica Gmbh Liquid composition for veterinary medicine and process for the preparation and use thereof
US20050288280A1 (en) * 2004-06-23 2005-12-29 Boehringer Ingelheim Vetmedica Gmbh Meloxicam in veterinary medicine
US6986346B2 (en) * 1998-10-17 2006-01-17 Boehringer Ingelheim Pharma Kg Closure-cap and container as a two-chamber cartridge for nebulisers for producing aerosols and active substance formulations, suitable for storage
US20060217431A1 (en) * 2005-03-23 2006-09-28 Boehringer Ingelheim International Gmbh Composition comprising a combined thromboxane receptor antagonist and thromboxane synthase inhibitor and a COX-2 inhibitor
US20070077296A1 (en) * 2005-09-30 2007-04-05 Folger Martin A Pharmaceutical Preparation containing Meloxicam
US20080234380A1 (en) * 1992-06-30 2008-09-25 Shapiro Howard K Compositions and method for treatment of chronic inflammatory diseases
US7969206B2 (en) * 2007-05-21 2011-06-28 Denso Corporation Semiconductor element drive circuit
US20110275618A1 (en) * 2010-05-05 2011-11-10 Boehringer Ingelheim Vetmedica Gmbh Novel low concentration meloxicam tablets
US20120077764A1 (en) * 2003-05-29 2012-03-29 Freehauf Keith A Compositions and method for treating infection in cattle and swine

Family Cites Families (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089818A (en) 1960-06-02 1963-05-14 Baxter Laboratories Inc Water dispersible antibiotics
JPS477352Y1 (en) 1969-06-13 1972-03-17
JPS52102416A (en) 1976-02-19 1977-08-27 Okawara Mfg Granule making method of herb medicine and like
FR2437838A1 (en) 1978-07-25 1980-04-30 Roecar Holdings Nv Prostaglandin inhibitors for benign adenoma of the prostate - includes salicylic, anthranilic and phenylacetic acid derivs., indole(s), indene(s), pyrrole(s) and pyrazolidine(s)
IE49768B1 (en) 1979-05-21 1985-12-11 Leo Pharm Prod Ltd 6beta-halopenicillanic acid derivatives
JPS56110665A (en) 1980-02-08 1981-09-01 Yamanouchi Pharmaceut Co Ltd Sulfamoyl-substituted phenetylamine derivative and its preparation
IE51846B1 (en) 1980-11-17 1987-04-15 Leo Pharm Prod Ltd Pharmaceutical preparation for veterinary use and an appliance containing it
US4447443A (en) 1982-11-15 1984-05-08 Merck & Co., Inc. Anti-inflammatory/analgesic combination of α-fluoromethylhistidine and a selected non-steroidal anti-inflammatory drug (NSAID)
EP0127400A3 (en) 1983-05-31 1986-06-11 Stauffer Chemical Company Magnesium oxide containing vehicle for direct compression tableting
IT1212778B (en) 1983-10-07 1989-11-30 Lisapharma Spa PHARMACEUTICAL COMPOSITIONS ANTI-INFLAMMATORY AND / OR ANALGESIC ADAPTERITY, NON ULCEROGENE.
JPH0753663B2 (en) 1984-10-09 1995-06-07 武田薬品工業株式会社 Thiamine salt granules, their production and tablets
IT1196307B (en) 1984-10-22 1988-11-16 Chiesi Farma Spa AQUEOUS PHARMACEUTICAL FORMULATIONS OF PIROXICAM MONOHYDRATE
US4687662A (en) 1985-08-30 1987-08-18 Warner-Lambert Company Therapeutic effervescent composition
SE8605515D0 (en) 1986-12-22 1986-12-22 Astra Laekemedel Ab A LIQUID DOSAGE FORM FOR ORAL ADMINISTRATION OF A PHARMACEUTICALLY ACTIVE SUBSTANCE
US5026560A (en) 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
IL83086A (en) 1987-07-06 1991-03-10 Teva Pharma Stable,injectable solutions of vincristine salts
FI94924C (en) 1987-09-11 1995-11-27 Syntex Inc Process for the preparation of an antimicrobial acting preservative system for ophthalmologically acceptable drugs
JPH02134375A (en) 1988-09-21 1990-05-23 G D Searle & Co 3-oxiranyl benzoic acid and its derivative
DE68916497T2 (en) 1988-09-30 1994-11-17 Rhone Poulenc Rorer Ltd Pharmaceutical granules.
US5178878A (en) 1989-10-02 1993-01-12 Cima Labs, Inc. Effervescent dosage form with microparticles
IL95942A0 (en) 1989-10-13 1991-07-18 Syntex Inc Collagen-containing ophthalmic formulation
KR920002148A (en) 1990-07-03 1992-02-28 안드레아 엘. 콜비 Pharmaceutical compositions for alleviating gastrointestinal symptoms caused by nonsteroidal anti-inflammatory drugs and methods for alleviating the same
US5552160A (en) 1991-01-25 1996-09-03 Nanosystems L.L.C. Surface modified NSAID nanoparticles
HU221677B1 (en) 1991-01-30 2002-12-28 Wellcome Foundation Ltd. Water-dispersible tablets and process for production of them
JP3541849B2 (en) 1991-04-19 2004-07-14 久光製薬株式会社 Anti-inflammatory analgesic patch
FR2679135B1 (en) 1991-07-18 1995-05-19 Europhta Sa Laboratoire NOVEL OPHTHALMIC COMPOSITIONS WITH IMPROVED ADHESIVITY AND METHODS OF PREPARING THE SAME.
US5464632C1 (en) 1991-07-22 2001-02-20 Prographarm Lab Rapidly disintegratable multiparticular tablet
GB9122820D0 (en) 1991-10-28 1991-12-11 Wellcome Found Stabilised antibodies
IT1251650B (en) 1991-10-29 1995-05-17 Boehringer Ingelheim Italia Inclusion compounds of meloxicam with cyclodextrin
JP2860729B2 (en) 1992-03-10 1999-02-24 エスエス製薬株式会社 Planoprofen suspension syrup
DE4217971C1 (en) 1992-05-30 1993-10-21 Boehringer Ingelheim Vetmed Process and fluid bed apparatus for granulating and / or wrapping
US5455271A (en) 1992-06-18 1995-10-03 The Scripps Research Institute Tight-binding inhibitors of leukotriene A4 hydrolase
KR0169505B1 (en) 1992-09-11 1999-01-15 오오쓰끼 아끼히꼬 Drug packing polyolefinic material, process for producing the same and container for drug packing
JPH06157312A (en) 1992-11-12 1994-06-03 Shionogi & Co Ltd Bitterness-improved dry syrup granule of terfenadine
IT1264020B (en) 1993-01-28 1996-09-09 Recordati Chem Pharm PROCEDURE FOR THE PREPARATION OF MICROGRANULES SUITABLE FOR SUSPENSION IN LIQUIDS
ES2065846B1 (en) 1993-04-20 1995-10-01 Cusi Lab PHARMACEUTICAL FORMULATION BASED ON A STEROID OR NON-STEROID ANTI-INFLAMMATORY AGENT AND AN ANTIBIOTIC BELONGING TO THE GIRASE DNA INHIBITORS GROUP FOR ITS TOPICAL OPHTHALMIC USE.
DE4322826A1 (en) 1993-07-08 1995-01-12 Galenik Labor Freiburg Gmbh Pharmaceutical preparation
US5676944A (en) 1993-10-06 1997-10-14 The Regents Of The University Of California Ocular therapy with homologous macrophages
US5474985A (en) 1993-12-22 1995-12-12 The Regents Of The University Of California Preventing and treating elevated intraocular pressure associated with administered or endogenous steroids using non-steroidal cyclooxygenase inhibitors
AU1249395A (en) 1994-01-11 1995-08-01 Ciba-Geigy Ag Topical treatment of ocular photophobia
US5620999A (en) 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
US5616601A (en) 1994-07-28 1997-04-01 Gd Searle & Co 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation
US5585492A (en) 1994-10-11 1996-12-17 G. D. Searle & Co. LTA4 Hydrolase inhibitors
US6506876B1 (en) 1994-10-11 2003-01-14 G.D. Searle & Co. LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
JP3550782B2 (en) 1995-03-14 2004-08-04 大日本インキ化学工業株式会社 Expandable particles of lactic acid-based polyester
US5599535A (en) 1995-06-07 1997-02-04 Regents Of The University Of California Methods for the cyto-protection of the trabecular meshwork
US5674888A (en) 1995-06-07 1997-10-07 University Of California Method for the treatment of a trabecular meshwork whose cells are subject to inhibition of cell division
JPH0912426A (en) 1995-06-29 1997-01-14 Asahi Chem Ind Co Ltd Hygroscopic material composition
EA005073B1 (en) 1995-07-19 2004-10-28 Мерк Энд Ко., Инк. Use of 3-phenyl-4-(4-methylsulfonylphenyl)-2-(5h)-furanone for treating or preventing of a colonic adenoma
EP0839029A1 (en) 1995-07-20 1998-05-06 PHARMACIA &amp; UPJOHN COMPANY Stable clear solutions of non-steroidal anti-inflammatory drugs for incorporation into gelatin capsules
FR2739562B1 (en) 1995-10-09 1998-04-24 Moreau Defarges Alain JET INJECTION DEVICE WITHOUT NEEDLE, INCLUDING AN OVER-MOLDED CARTRIDGE
US5686414A (en) 1995-11-14 1997-11-11 Xoma Corporation Methods of treating conditions associated with corneal transplantation
DE69709069T2 (en) 1996-02-13 2002-07-04 Searle & Co COMPOSITIONS WITH IMMUNOSUPPRESSIVE EFFECTS CONTAINING 5-LIPOXYGENASE INHIBITORS AND CYCLOOXYGENASE-2 INHIBITORS
EP0889724A1 (en) 1996-02-27 1999-01-13 Rpms Technology Limited Cox-2 selective inhibitors for managing labour and uterine contractions
US6048557A (en) 1996-03-26 2000-04-11 Dsm N.V. PUFA coated solid carrier particles for foodstuff
ATA156496A (en) 1996-09-03 1997-10-15 Nycomed Austria Gmbh PHARMACEUTICAL COMPOSITION
GB2318511A (en) 1996-10-23 1998-04-29 Eurand Int Process for the preparation of a pharmaceutical composition for rapid suspension in water
JP3338064B2 (en) 1997-01-06 2002-10-28 ファイザー・インク Cyclic sulfone derivative
CN1062161C (en) 1997-01-08 2001-02-21 大连弘丰制药厂 Stable prescription and process of fleabane extract injection
FR2758459B1 (en) 1997-01-17 1999-05-07 Pharma Pass FENOFIBRATE PHARMACEUTICAL COMPOSITION HAVING HIGH BIODAVAILABILITY AND PROCESS FOR PREPARING THE SAME
US5891129A (en) 1997-02-28 1999-04-06 Abbott Laboratories Container cap assembly having an enclosed penetrator
JP3608800B2 (en) 1997-03-26 2005-01-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Pellet with core coated with antifungal agent and polymer
US6479473B1 (en) 1997-05-06 2002-11-12 Norbrook Laboratories Ltd. Long-acting antimicrobials
JP4936579B2 (en) 1997-09-05 2012-05-23 第一三共株式会社 Loxoprofen-containing pharmaceutical preparation
GB9726701D0 (en) 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
CN1205921C (en) 1997-12-03 2005-06-15 麦克公司 Long cating injectable formulations contg. hydrogenated castor oil
WO1999039730A1 (en) 1998-02-09 1999-08-12 Kaken Pharmaceutical Co., Ltd. Oral preparations containing peptides promoting the secretion of growth hormone
EP0945131A1 (en) 1998-03-27 1999-09-29 Boehringer Ingelheim Pharma KG Peroral drug suspension
AU3536299A (en) 1998-04-29 1999-11-16 Sumitomo Pharmaceuticals Company, Limited Oral formulation comprising biguanide and an organic acid
US6132758A (en) 1998-06-01 2000-10-17 Schering Corporation Stabilized antihistamine syrup
EP1109534B1 (en) 1998-09-10 2003-02-12 Nycomed Danmark A/S Quick release pharmaceutical compositions of drug substances
US7067144B2 (en) 1998-10-20 2006-06-27 Omeros Corporation Compositions and methods for systemic inhibition of cartilage degradation
GB9823246D0 (en) 1998-10-24 1998-12-16 Danbiosyst Uk A nasal drug delivery composition
FR2796840B1 (en) 1999-07-26 2003-06-20 Ethypharm Lab Prod Ethiques LOW-DOSE TABLETS AND METHOD OF PREPARATION
US6552020B1 (en) 1999-07-30 2003-04-22 Allergan, Inc. Compositions including antibiotics and methods for using same
EP1202716A1 (en) 1999-08-17 2002-05-08 Novartis Consumer Health S.A. Rapidly dissolving dosage form and process for making same
KR200182299Y1 (en) 1999-12-08 2000-05-15 장지일 Floss holder having floss case
JP2001172183A (en) 1999-12-21 2001-06-26 Wakamoto Pharmaceut Co Ltd Ophthalmic pharmaceutical composition
IN191512B (en) 2000-01-21 2003-12-06 Panacea Biotech
DE10010123A1 (en) 2000-03-03 2001-09-20 Boehringer Ingelheim Int Needle-less injector for liquids comprises a tensioning system, an energy storing spring, a hollow piston in a cylinder, and a nozzle
US6689092B2 (en) 2000-03-03 2004-02-10 Boehringer International Gmbh Needle-less injector of miniature type
DE10024752A1 (en) 2000-05-16 2001-11-29 Ben Pfeifer Composition for treating prostate diseases, especially inflammation, hyperplasia or cancer, comprises active agent solution containing dimethyl sulfoxide or hyaluronidase as diffusion promoter, applied using catheter
DE10030345A1 (en) 2000-06-20 2002-01-10 Boehringer Ingelheim Vetmed Highly concentrated stable meloxicam solutions
GB0022215D0 (en) 2000-09-11 2000-10-25 Boehringer Ingelheim Pharma Method for the treatment of thromboembolic disorders in patients with aspirin« resistance
US6787568B1 (en) 2000-11-27 2004-09-07 Phoenix Scientific, Inc. Antibiotic/analgesic formulation and a method of making this formulation
ES2307568T3 (en) * 2000-12-08 2008-12-01 Coley Pharmaceutical Gmbh CPG TYPE NUCLEIC ACIDS AND SAME USE METHODS.
DE10300323A1 (en) 2003-01-09 2004-10-14 Baxter Healthcare S.A. Safety container filled with a biologically active substance, especially a cytostatic agent, is at least partially coated
US6995190B2 (en) 2001-03-09 2006-02-07 Veterinary Solutions Method and treatment with ketoprofen solution
EP1250921A1 (en) 2001-04-21 2002-10-23 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Fast disintegrating meloxicam tablet
AUPR527801A0 (en) 2001-05-25 2001-06-21 University Of Sydney, The Animal husbandry iii
EP1348436A1 (en) 2002-03-30 2003-10-01 Boehringer Ingelheim International GmbH Meloxicam suppositories
US20050020657A1 (en) 2002-07-09 2005-01-27 B.M.R.A. Corporation B.V. Compositions and methods involving the combination of a thromboxane A2 receptor antagonist and an inhibitor of cyclooxygenase-2
WO2004026116A2 (en) 2002-09-19 2004-04-01 The Regents Of The University Of California Use of etodoclac to treat hyperplasia
DE10250081A1 (en) * 2002-10-25 2004-05-13 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
US20040170687A1 (en) 2003-02-27 2004-09-02 Integrity Pharmaceutical Corporation Compositions with improved stability and methods of formulation thereof
DE10315702A1 (en) 2003-04-07 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of drug combinations for the treatment of benign prostatic hyperplasia or for the treatment of abacterial prostatitis
JP4018022B2 (en) 2003-04-10 2007-12-05 株式会社ホシモト Opening and closing handle device
WO2004103283A2 (en) 2003-05-14 2004-12-02 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a central nervous system stimulant for the treatment of central nervous system damage
JP2009513512A (en) 2003-07-09 2009-04-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Composition comprising meloxicam
CN1233323C (en) 2003-12-09 2005-12-28 成都圣诺科技发展有限公司 Orally disintegrating tablet of meloxicam and its preparation
CA2562305A1 (en) 2004-04-08 2005-10-20 Idd-Eal Manufacturing Company Limited Container for constituting a formulation in liquid form
CN101005830B (en) 2004-08-13 2010-09-29 贝林格尔·英格海姆国际有限公司 Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
ATE404206T1 (en) 2004-12-06 2008-08-15 Janssen Pharmaceutica Nv ORAL SUSPENSION WITH MELOXICAM
DE602006012732D1 (en) 2005-12-20 2010-04-15 Basell Poliolefine Srl EL
US20070187405A1 (en) 2006-01-23 2007-08-16 Pujara Chetan P Container for compositions containing cefdinir
JP4965130B2 (en) 2006-01-26 2012-07-04 日本臓器製薬株式会社 Dry type quick-disintegrating tablet
US20070249727A1 (en) 2006-04-21 2007-10-25 The Proctor & Gamble Company Compositions and kits useful for treatment of respiratory illness
ITMI20060983A1 (en) 2006-05-18 2007-11-19 Formevet S P A VETERINARY PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PAIN AND INFLAMMATION
EP2117506A2 (en) 2006-12-13 2009-11-18 Stephen M. Tuel Methods of making pharmaceutical components for customized drug products
BRPI0700969A (en) 2007-03-22 2008-11-04 Ouro Fino Participacoes E Empr composition for the treatment of bacterial and inflammatory conditions in pet animals
FR2917381B1 (en) 2007-06-15 2009-10-16 Ceva Sante Animale Sa MULTILAYER PLASTIC PACKAGING FOR PRESERVING A PHARMACEUTICAL COMPOSITION
WO2009049304A1 (en) 2007-10-12 2009-04-16 Map Pharmaceuticals, Inc. Inhalation drug delivery
GB0724707D0 (en) 2007-12-19 2008-01-30 Burke Michael H A process for the preparation of an orally administered unit dose tablet
JP5559339B2 (en) 2009-10-12 2014-07-23 ベーリンガー インゲルハイム フェトメディカ ゲゼルシャフト ミット ベシュレンクテル ハフツング Container for compositions containing meloxicam
MX2012010077A (en) 2010-03-03 2012-09-12 Boehringer Ingelheim Vetmed Use of meloxicam for the long-term treatment of musculoskeletal disorders in cats.
US20110218191A1 (en) 2010-03-03 2011-09-08 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam for the long term-treatment of kidney disorders in cats

Patent Citations (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2795529A (en) * 1954-06-17 1957-06-11 American Home Prod Stabilized hyaluronidase solution containing calcium chloride
US3288675A (en) * 1964-03-20 1966-11-29 Hoffmann La Roche Parenteral sulfonamide compositions and processes
US3849549A (en) * 1971-10-06 1974-11-19 Merck & Co Inc Indomethacin suppositories
US3931212A (en) * 1973-07-19 1976-01-06 Warner-Lambert Company Method for treating cardiovascular circulatory insufficiencies and hypotonia with 2-hydroxy-phenyl-1-oxa-4-azaspiroalkane derivatives
US3947576A (en) * 1973-09-27 1976-03-30 Mortell Company Synergistic biostatic composition
US4233299A (en) * 1977-12-16 1980-11-11 Boehringer Ingelheim Gmbh 4-Hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides and salts thereof
US4482554A (en) * 1982-05-08 1984-11-13 Warner-Lambert Company Pharmaceutical compositions containing oxicam derivatives and process for their preparation
US4543200A (en) * 1983-09-28 1985-09-24 Sherman Laboratories, Inc. Contact lens preservative system cleaner and method
US4794117A (en) * 1984-03-03 1988-12-27 Jerome Corbiere Process for solubilizing active ingredients and the thus-obtained pharmaceutical compositions
US4628053A (en) * 1984-10-10 1986-12-09 Heinrich Mack Nachf. Stabilized injectable solutions of piroxicam
US4748174A (en) * 1986-01-03 1988-05-31 Therapicon S.R.L. Water soluble salts of an NSAID with meglumine/glucamine
US4802926A (en) * 1986-03-21 1989-02-07 Dmv-Campina B.V. Spray dried lactose and process for preparing the same
US4835187A (en) * 1987-06-15 1989-05-30 American Home Products Corporation Spray dried ibuprofen
US5414011A (en) * 1987-09-11 1995-05-09 Syntex (U.S.A.) Inc. Preservative system for ophthalmic formulations
US4942167A (en) * 1988-04-01 1990-07-17 Chiesi Farmaceutici S.P.A. Pharmaceutical compositions of piroxicam in aqueous solutions and process for their preparation
US5360611A (en) * 1988-10-03 1994-11-01 Alcon Laboratories, Inc. Pharmaceutical compositions and methods of treatment of the cornea following ultraviolet laser irradiation
US5283065A (en) * 1989-09-21 1994-02-01 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
US5824658A (en) * 1990-09-18 1998-10-20 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5169847A (en) * 1990-11-27 1992-12-08 Egis Gyogyszergyar Drug solutions of increased stability and without tissue-damaging effect and process for preparing same
US5654003A (en) * 1992-03-05 1997-08-05 Fuisz Technologies Ltd. Process and apparatus for making tablets and tablets made therefrom
US20080234380A1 (en) * 1992-06-30 2008-09-25 Shapiro Howard K Compositions and method for treatment of chronic inflammatory diseases
US5304561A (en) * 1992-07-24 1994-04-19 Faezeh Sarfarazi New concept in glaucoma treatment
US5380934A (en) * 1992-10-29 1995-01-10 Kyowa Hakko Kogyo Co., Ltd. Process for producing alanylgutamine
US5886030A (en) * 1994-05-06 1999-03-23 Alcon Laboratories, Inc. Use of vitamin E tocopheryl derivatives in ophthalmic compositions
US5700816A (en) * 1995-06-12 1997-12-23 Isakson; Peter C. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
US6221377B1 (en) * 1995-11-13 2001-04-24 Pitmy International N.V. Administration media for analgesic, anti-inflammatory and anti-pyretic drugs containing nitrous oxide and pharmaceutical compositions containing such media and drugs
US6187800B1 (en) * 1996-06-20 2001-02-13 Novartis Animal Health U.S., Inc. Method for the prevention and treatment of mastitis
US20020068088A1 (en) * 1996-08-15 2002-06-06 Peter Gruber Easy to swallow oral medicament composition
US6071539A (en) * 1996-09-20 2000-06-06 Ethypharm, Sa Effervescent granules and methods for their preparation
US5811446A (en) * 1997-04-18 1998-09-22 Cytos Pharmaceuticals Llc Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6630056B1 (en) * 1997-07-10 2003-10-07 Thibierge & Comar Color tracing paper
US6605295B1 (en) * 1997-07-11 2003-08-12 Bausch & Lomb Incorporated Storage-stable ophthalmic compositions comprising diclofenac and ofloxacin
US6284269B1 (en) * 1997-08-27 2001-09-04 Hexal Ag Pharmaceutical compositions of meloxicam with improved solubility and bioavailability
US6599529B1 (en) * 1997-09-11 2003-07-29 Nycomed Danmark A/S Modified release multiple-units compositions of non-steroid anti-inflammatory drug substances (NSAIDs)
US20020099049A1 (en) * 1997-09-17 2002-07-25 Burch Ronald M. Analgesic combination of oxycodone and meloxicam
US6046191A (en) * 1997-10-10 2000-04-04 Astra Pharmaceuticals Ltd. Combination
US5962012A (en) * 1997-11-28 1999-10-05 Caleb Pharmaceuticals, Inc. Cholinergic antagonist patch
US6136804A (en) * 1998-03-13 2000-10-24 Merck & Co., Inc. Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions
US6869948B1 (en) * 1998-03-27 2005-03-22 Boehringer Ingelheim Pharma Kg Meloxicam for oral administration
US6184220B1 (en) * 1998-03-27 2001-02-06 Boehringer Ingelheim Pharma Kg Oral suspension of pharmaceutical substance
US6682747B1 (en) * 1998-03-27 2004-01-27 Boehringer Ingelheim Pharma Kg Process for preparing an oral suspension of a pharmaceutical substance
US6495603B1 (en) * 1998-05-15 2002-12-17 Wakamoto Pharmaceutical Co., Ltd. Anti-inflammatory eye drop
US6319519B2 (en) * 1998-07-07 2001-11-20 Norton Healthcare Ltd. Anti-inflammatory pharmaceutical formulations
US6106862A (en) * 1998-08-13 2000-08-22 Andrx Corporation Once daily analgesic tablet
US6986346B2 (en) * 1998-10-17 2006-01-17 Boehringer Ingelheim Pharma Kg Closure-cap and container as a two-chamber cartridge for nebulisers for producing aerosols and active substance formulations, suitable for storage
US6180136B1 (en) * 1998-11-10 2001-01-30 Idexx Laboratories, Inc. Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use
US6156349A (en) * 1998-12-14 2000-12-05 Steinbach, Pylant And Herman, L.L.C. Method of treating HIV infection with suppository containing mammalian liver extract
US6183779B1 (en) * 1999-03-22 2001-02-06 Pharmascience Inc. Stabilized pharmaceutical composition of a nonsteroidal anti-inflammatory agent and a prostaglandin
US6166012A (en) * 1999-07-30 2000-12-26 Allergan Sales, Inc. Antibiotic compositions and method for using same
US6669957B1 (en) * 1999-09-15 2003-12-30 Cll Pharma Galenic formulations fast disintegrating in the mouth and method for preparing same
US20030055051A1 (en) * 1999-11-24 2003-03-20 Wakamoto Pharmaceutical Co., Ltd. Ophthalmic aqueous pharmaceutical preparation
US7105512B2 (en) * 1999-11-24 2006-09-12 Wakamoto Pharmaceutical Co., Ltd. Ophthalmic aqueous pharmaceutical preparation
US20020106345A1 (en) * 1999-12-07 2002-08-08 Uhrich Kathryn E. Therapeutic compositions and methods
US6550955B2 (en) * 2000-05-03 2003-04-22 D'silva Joe Process for producing liquid dosage formulations of medicinal compounds on demand from tablets and capsules using a mixing cup with an abrasive interior surface
US20020016342A1 (en) * 2000-05-15 2002-02-07 Edward Scolnick Combination therapy using COX-2 selective inhibitor and thromboxane inhibitor and compositions therefor
US20030050305A1 (en) * 2000-05-22 2003-03-13 Tejada Inigo Saenz De Thromboxane inhibitors, compositions and methods of use
US20020035107A1 (en) * 2000-06-20 2002-03-21 Stefan Henke Highly concentrated stable meloxicam solutions
US20060079516A1 (en) * 2000-06-20 2006-04-13 Boehringer Ingelheim Vetmedica Gmbh Highly concentrated stable meloxicam solutions
US20040024041A1 (en) * 2000-07-01 2004-02-05 Torsten Selzer Dermal therapeutic system containing non-steroidal antiphlogistics with selective cox-2 inhibition
US20020006440A1 (en) * 2000-07-05 2002-01-17 Cherukuri Subraman Rao Rapid-melt semi-solid compositions, methods of making same and methods of using same
US20020077328A1 (en) * 2000-07-13 2002-06-20 Fred Hassan Selective cyclooxygenase-2 inhibitors and vasomodulator compounds for generalized pain and headache pain
US20040204413A1 (en) * 2001-01-26 2004-10-14 Joaquina Faour Pharmaceutical compositions containing a COX-II inhibitor and a muscle relaxant
US20030199482A1 (en) * 2001-03-28 2003-10-23 Pharmacia Corporation Therapeutic combinations for cardiovascular and inflammatory indications
US20020187187A1 (en) * 2001-04-21 2002-12-12 Toshimitsu Ohki Fast disintegrating meloxicam tablet
US20050244491A1 (en) * 2001-04-21 2005-11-03 Boehringer Ingelheim International Gmbh Fast disintegrating meloxicam tablet
US20040234596A1 (en) * 2001-04-21 2004-11-25 Boehringer Ingelheim International Gmbh Fast disintegrating meloxicam tablet
US20040253312A1 (en) * 2001-09-28 2004-12-16 Sowden Harry S. Immediate release dosage form comprising shell having openings therein
US20030220306A1 (en) * 2001-09-28 2003-11-27 Daniel Simmons Novel cyclooxygenase variants and methods of use
US20030109701A1 (en) * 2001-12-11 2003-06-12 Laura Coppi Crystalline forms of meloxicam and processes for their preparation and interconversion
US20080132493A1 (en) * 2001-12-12 2008-06-05 Martin Andreas Folger Highly concentrated stable meloxicam solutions for needleless injection
US20030119825A1 (en) * 2001-12-12 2003-06-26 Boehringer Ingelheim Vetmedica Gmbh Highly concentrated stable meloxicam solutions for needleless injection
US20040001883A1 (en) * 2002-03-30 2004-01-01 Boehringer Ingelheim International Gmbh Meloxicam suppositories
US20040024042A1 (en) * 2002-04-02 2004-02-05 Vanderbilt University COX2 inhibition in the prevention and treatment of autosomal dominant polycystic kidney disease
US20040043992A1 (en) * 2002-05-22 2004-03-04 Boehringer Ingelheim International Gmbh Meloxicam for alleviating organ injury during organ operation or transplantation
US20040037869A1 (en) * 2002-08-16 2004-02-26 Douglas Cleverly Non-animal product containing veterinary formulations
US20050187212A1 (en) * 2002-09-17 2005-08-25 Nippon Boehringer Ingelheim Co., Ltd. Pharmaceutical composition for topical delivery of meloxicam
US20040171611A1 (en) * 2002-09-30 2004-09-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline acetic acid solvate of meloxicam
US20040180092A1 (en) * 2002-10-25 2004-09-16 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
US20040110747A1 (en) * 2002-12-06 2004-06-10 Boehringer Ingelheim International Gmbh Use of meloxicam in combination with an antiplatelet agent for treatment of acute coronary syndrome and related conditions
US20050197332A1 (en) * 2002-12-10 2005-09-08 Boehringer Ingelheim International Use of meloxicam in combination with an antiplatelet agent for treatment of acute coronary syndrome and related conditions
US20070099907A1 (en) * 2002-12-10 2007-05-03 Raul Altman Use of meloxicam in combination with an antiplatelet agent for treatment of acute coronary syndrome and related conditions
US20060160793A1 (en) * 2002-12-10 2006-07-20 Boehringer Ingelheim International Gmbh Use of meloxicam in combination with an antiplatelet agent for treatment of acute coronary syndrome and related conditions
US20040229038A1 (en) * 2003-03-03 2004-11-18 Elan Pharma International Ltd. Nanoparticulate meloxicam formulations
US20040204472A1 (en) * 2003-03-04 2004-10-14 Pharmacia Corporation Treatment and prevention of obesity with COX-2 inhibitors alone or in combination with weight-loss agents
US20040214753A1 (en) * 2003-03-20 2004-10-28 Britten Nancy Jean Dispersible pharmaceutical composition for treatment of mastitis and otic disorders
US20040198826A1 (en) * 2003-04-07 2004-10-07 Boehringer Ingelheim International Gmbh Pharmaceutical combination for treating benign prostatic hyperplasia or for treating abacterial prostatitis
US20120077764A1 (en) * 2003-05-29 2012-03-29 Freehauf Keith A Compositions and method for treating infection in cattle and swine
US20050038018A1 (en) * 2003-07-09 2005-02-17 Boehringer Ingelheim International Gmbh Meloxicam compositions
US20050147664A1 (en) * 2003-11-13 2005-07-07 Elan Pharma International Ltd. Compositions comprising antibodies and methods of using the same for targeting nanoparticulate active agent delivery
US20050187213A1 (en) * 2004-02-23 2005-08-25 Boehringer Ingelheim Vetmedica Gmbh Meloxicam for the treatment of respiratory diseases in pigs
US20050245510A1 (en) * 2004-04-29 2005-11-03 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam formulations in veterinary medicine
US20050277634A1 (en) * 2004-05-19 2005-12-15 Boehringer Ingelheim Vetmedica Gmbh Liquid composition for veterinary medicine and process for the preparation and use thereof
US20050288280A1 (en) * 2004-06-23 2005-12-29 Boehringer Ingelheim Vetmedica Gmbh Meloxicam in veterinary medicine
US20060217431A1 (en) * 2005-03-23 2006-09-28 Boehringer Ingelheim International Gmbh Composition comprising a combined thromboxane receptor antagonist and thromboxane synthase inhibitor and a COX-2 inhibitor
US20070077296A1 (en) * 2005-09-30 2007-04-05 Folger Martin A Pharmaceutical Preparation containing Meloxicam
US7969206B2 (en) * 2007-05-21 2011-06-28 Denso Corporation Semiconductor element drive circuit
US20110275618A1 (en) * 2010-05-05 2011-11-10 Boehringer Ingelheim Vetmedica Gmbh Novel low concentration meloxicam tablets

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Zaghawa et al. (Clinical and Etiological study on respiratory affections of sheep By Zaghawa A., Hassan H., and El-Sify A. Faculty of veterinary medicine-Sadat city -Menoufia University Animal medicine and infectiuos diseases department Abstract). *

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060079516A1 (en) * 2000-06-20 2006-04-13 Boehringer Ingelheim Vetmedica Gmbh Highly concentrated stable meloxicam solutions
US9993557B2 (en) 2000-06-20 2018-06-12 Boehringer Ingelheim Vetmedica Gmbh Highly concentrated stable meloxicam solutions
US9956288B2 (en) 2000-06-20 2018-05-01 Boehringer Ingelheim Vetmedica Gmbh Highly concentrated stable meloxicam solutions
US20080132493A1 (en) * 2001-12-12 2008-06-05 Martin Andreas Folger Highly concentrated stable meloxicam solutions for needleless injection
US10098891B2 (en) 2001-12-12 2018-10-16 Boehringer Ingelheim Vetmedica Gmbh Highly concentrated stable meloxicam solutions for needleless injection
US8920820B2 (en) 2001-12-12 2014-12-30 Boehringer Ingelheim Vetmedica Gmbh Highly concentrated stable meloxicam solutions for needleless injection
US20040180092A1 (en) * 2002-10-25 2004-09-16 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
US8992980B2 (en) 2002-10-25 2015-03-31 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
US9066955B2 (en) 2002-10-25 2015-06-30 Boehringer Ingelheim Vetmedica Gmbh Water-soluble meloxicam granules
US11083731B2 (en) 2004-02-23 2021-08-10 Boehringer Ingelheim Vetmedica Gmbh Meloxicam for the treatment of respiratory diseases in pigs
US10548901B2 (en) 2004-02-23 2020-02-04 Boehringer Ingelheim Vetmedica Gmbh Meloxicam for the treatment of respiratory diseases in pigs
US20050245510A1 (en) * 2004-04-29 2005-11-03 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam formulations in veterinary medicine
US20050288280A1 (en) * 2004-06-23 2005-12-29 Boehringer Ingelheim Vetmedica Gmbh Meloxicam in veterinary medicine
US20070077296A1 (en) * 2005-09-30 2007-04-05 Folger Martin A Pharmaceutical Preparation containing Meloxicam
US9186296B2 (en) 2009-10-12 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh Containers for compositions comprising meloxicam
US9101529B2 (en) 2009-10-12 2015-08-11 Boehringer Ingelheim Vetmedica Gmbh Containers for compositions comprising meloxicam
US20110083985A1 (en) * 2009-10-12 2011-04-14 Boehringer Ingelheim Vetmedica Gmbh Containers for compositions comprising meloxicam
US9149480B2 (en) 2010-03-03 2015-10-06 Boehringer Ingeleheim Vetmedica GmbH Use of meloxicam for the long-term treatment of musculoskeletal disorders in cats
US9795568B2 (en) 2010-05-05 2017-10-24 Boehringer Ingelheim Vetmedica Gmbh Low concentration meloxicam tablets
US9943486B2 (en) 2010-05-05 2018-04-17 Boehringer Ingelheim Vetmedica Gmbh Low concentration meloxicam tablets

Also Published As

Publication number Publication date
ES2394038T3 (en) 2013-01-16
CA2554040C (en) 2014-08-05
US20140179639A1 (en) 2014-06-26
JP5009147B2 (en) 2012-08-22
US11083731B2 (en) 2021-08-10
EP1720554A1 (en) 2006-11-15
CN1921865A (en) 2007-02-28
KR20070033960A (en) 2007-03-27
BRPI0507966A (en) 2007-07-17
AU2005215122A1 (en) 2005-09-01
EP1720554B1 (en) 2012-07-18
CN1921865B (en) 2010-06-16
US10548901B2 (en) 2020-02-04
SG150531A1 (en) 2009-03-30
US20050187213A1 (en) 2005-08-25
TW200533362A (en) 2005-10-16
WO2005079806A1 (en) 2005-09-01
US20180185380A1 (en) 2018-07-05
JP2007523205A (en) 2007-08-16
KR101233359B1 (en) 2013-02-13
MXPA06009575A (en) 2007-03-15
DK1720554T3 (en) 2012-10-15
US20200121692A1 (en) 2020-04-23
EP1568369A1 (en) 2005-08-31
RU2360680C2 (en) 2009-07-10
CA2554040A1 (en) 2005-09-01
RU2006133829A (en) 2008-03-27
UA92584C2 (en) 2010-11-25
AU2005215122B2 (en) 2011-08-11

Similar Documents

Publication Publication Date Title
US11083731B2 (en) Meloxicam for the treatment of respiratory diseases in pigs
Wilson Rational selection of antimicrobials for use in horses
EP1462101B1 (en) Drinkable preparation comprising ketoprofen and use thereof in the simultaneous treatment of a group of animals of respiratory diseases
EP2293777B1 (en) Pharmaceutical transdermal compositions and method for treating inflammation in cattle
Constable et al. Guidelines for antimicrobial use in cattle
US7910620B2 (en) Uses of neuraminidase inhibitors in infectious diseases
US20210196685A1 (en) Composition for eradicating helicobacter pylori
ES2230802T3 (en) TREATMENT OF VIRAL INFECTION IN CERCOS.
JP5322649B2 (en) Cefquinome composition and method of use thereof
SK284791B6 (en) Use of 8a-azalides in the treatment or prevention of bacterial respiratory and enteric infections in livestock animals
US20180235941A1 (en) Pediatric oral suspension formulations of amoxicillin and clavulanate potassium and methods for using same
US20130005804A1 (en) Novel Uses of Neuraminidase Inhibitors in Infectious Diseases
Wormer Diagnosis: HELMINTHIASIS Prescription

Legal Events

Date Code Title Description
STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION

AS Assignment

Owner name: BOEHRINGER INGELHEIM VETMEDICA GMBH, GERMANY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:LANG, INGO;PAPATSAS, IOANNIS;SIGNING DATES FROM 20050330 TO 20050404;REEL/FRAME:051177/0810