EP1634587A3 - Film preparation for biphasic release of pharmacologically active or other substances - Google Patents
Film preparation for biphasic release of pharmacologically active or other substances Download PDFInfo
- Publication number
- EP1634587A3 EP1634587A3 EP05026782A EP05026782A EP1634587A3 EP 1634587 A3 EP1634587 A3 EP 1634587A3 EP 05026782 A EP05026782 A EP 05026782A EP 05026782 A EP05026782 A EP 05026782A EP 1634587 A3 EP1634587 A3 EP 1634587A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- substances
- pharmacologically active
- film preparation
- release
- biphasic release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002051 biphasic effect Effects 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 abstract 3
- 239000007788 liquid Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
Abstract
Eine filmförmige Zubereitung auf Polymer-Basis zur biphasigen Freisetzung von darin enthaltenen Substanzen an eine flüssige Umgebung ist dadurch gekennzeichnet, daß die Zubereitung mindestens zwei Polymermatrixschichten umfaßt, die sich hinsichtlich ihres Aufbaus aus Polymeren unterscheiden, wobei die Freisetzung aus einer der Schichten schnell erfolgt und die Freisetzung aus mindestens einer weiteren Schicht langsam erfolgt.A polymer-based film-like preparation for biphasic release of substances contained therein into a liquid environment is characterized in that the preparation comprises at least two polymer matrix layers which differ in their structure from polymers, wherein the release from one of the layers is rapid and the Release from at least one further layer slowly.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19954421A DE19954421A1 (en) | 1999-11-12 | 1999-11-12 | Film-like preparation for the biphase release of pharmacologically active or other substances |
EP00975993A EP1227802B1 (en) | 1999-11-12 | 2000-11-03 | Film preparation for biphasic release of pharmacologically active or other substances |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00975993A Division EP1227802B1 (en) | 1999-11-12 | 2000-11-03 | Film preparation for biphasic release of pharmacologically active or other substances |
EP00975993.7 Division | 2000-11-03 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1634587A2 EP1634587A2 (en) | 2006-03-15 |
EP1634587A3 true EP1634587A3 (en) | 2008-09-17 |
EP1634587B1 EP1634587B1 (en) | 2010-04-28 |
Family
ID=7928785
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00975993A Expired - Lifetime EP1227802B1 (en) | 1999-11-12 | 2000-11-03 | Film preparation for biphasic release of pharmacologically active or other substances |
EP05026782A Expired - Lifetime EP1634587B1 (en) | 1999-11-12 | 2000-11-03 | Film preparation for biphasic release of pharmacologically active or other substances |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00975993A Expired - Lifetime EP1227802B1 (en) | 1999-11-12 | 2000-11-03 | Film preparation for biphasic release of pharmacologically active or other substances |
Country Status (15)
Country | Link |
---|---|
US (3) | US7037526B1 (en) |
EP (2) | EP1227802B1 (en) |
JP (2) | JP4825385B2 (en) |
KR (1) | KR100677837B1 (en) |
CN (1) | CN100531724C (en) |
AT (2) | ATE465722T1 (en) |
AU (1) | AU777870B2 (en) |
CA (1) | CA2391393C (en) |
CY (1) | CY1105051T1 (en) |
DE (3) | DE19954421A1 (en) |
DK (1) | DK1227802T3 (en) |
ES (2) | ES2260068T3 (en) |
IL (2) | IL149572A0 (en) |
PT (1) | PT1227802E (en) |
WO (1) | WO2001035934A1 (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19954421A1 (en) * | 1999-11-12 | 2001-05-31 | Lohmann Therapie Syst Lts | Film-like preparation for the biphase release of pharmacologically active or other substances |
EP1504765B1 (en) * | 2002-05-16 | 2015-07-22 | Kyukyu Pharmaceutical Co., Ltd. | Quickly soluble film preparations |
US20040191302A1 (en) | 2003-03-28 | 2004-09-30 | Davidson Robert S. | Method and apparatus for minimizing heat, moisture, and shear damage to medicants and other compositions during incorporation of same with edible films |
US8999372B2 (en) | 2002-11-14 | 2015-04-07 | Cure Pharmaceutical Corporation | Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use |
US9561182B2 (en) | 2003-08-22 | 2017-02-07 | Cure Pharmaceutical Corporation | Edible films for administration of medicaments to animals, methods for their manufacture and methods for their use for the treatment of animals |
US20040131662A1 (en) | 2003-11-12 | 2004-07-08 | Davidson Robert S. | Method and apparatus for minimizing heat, moisture, and shear damage to medicants and other compositions during incorporation of same with edible films |
DE20307771U1 (en) * | 2003-05-19 | 2004-09-23 | Cofresco Frischhalteprodukte Gmbh & Co. Kg | Coating and bag |
US20050186257A1 (en) * | 2004-02-20 | 2005-08-25 | Todd Manegold | Dissolvable film and method of manufacture |
CA2633775A1 (en) | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
EP2471907B1 (en) | 2005-12-29 | 2018-09-26 | Celularity, Inc. | Placental stem cell populations |
US20070175484A1 (en) * | 2006-01-30 | 2007-08-02 | Staab Robert J | Condoms for beneficial agents delivery |
US7993918B2 (en) | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
US8263065B2 (en) | 2007-09-28 | 2012-09-11 | Anthrogenesis Corporation | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
JP5950577B2 (en) | 2008-08-20 | 2016-07-13 | アンスロジェネシス コーポレーション | Treatment of stroke using isolated placental cells |
WO2010021714A2 (en) | 2008-08-20 | 2010-02-25 | Anthrogenesis Corporation | Improved cell composition and methods of making the same |
MX2011005229A (en) | 2008-11-19 | 2011-06-16 | Anthrogenesis Corp | Amnion derived adherent cells. |
DE102008059206A1 (en) * | 2008-11-27 | 2010-06-10 | Bayer Schering Pharma Aktiengesellschaft | Pharmaceutical dosage form containing nifedipine or nisoldipine and an angiotensin II antagonist and / or a diuretic |
DK2952191T3 (en) | 2009-06-12 | 2018-12-10 | Sunovion Pharmaceuticals Inc | Sublingual apomorphine |
US9121007B2 (en) | 2010-01-26 | 2015-09-01 | Anthrogenesis Corporatin | Treatment of bone-related cancers using placental stem cells |
CN103097520B (en) | 2010-07-13 | 2017-12-05 | 人类起源公司 | The method for producing NK |
CN108175762A (en) * | 2010-09-23 | 2018-06-19 | 莫诺索尔克斯有限公司 | For forming the method and system of medicinal product directly on surface of package |
CA3115370A1 (en) | 2010-12-16 | 2012-06-21 | Sunovion Pharmaceuticals Inc. | Sublingual films comprising apomorphine and an organic base |
JP5831239B2 (en) | 2012-01-16 | 2015-12-09 | Tdk株式会社 | Bus bar and electronic equipment |
WO2014018075A1 (en) | 2012-07-23 | 2014-01-30 | Crayola, Llc | Dissolvable films and methods of using the same |
CN115137753A (en) | 2013-02-05 | 2022-10-04 | 细胞结构公司 | Natural killer cells from placenta |
CN107407680B (en) * | 2015-02-05 | 2019-11-01 | Ath澳大利亚私人有限公司 | For detecting the preparation including Organomercurial of disease |
JP7211706B2 (en) | 2015-04-21 | 2023-01-24 | サノヴィオン ファーマシュティカルズ インコーポレーテッド | Method for treating Parkinson's disease by administering apomorphine to oral mucosa |
CN105997958B (en) * | 2016-07-12 | 2019-03-26 | 中国人民解放军白求恩医务士官学校 | A kind of oral cavity external preparation and preparation method thereof |
WO2020077081A1 (en) * | 2018-10-11 | 2020-04-16 | Vitiprints, LLC | Dissolvable composition having indicia |
US20200281889A1 (en) * | 2019-03-07 | 2020-09-10 | Terpene Therapeutics Inc. | Edible Film Comprising Adjacent Conjoined Strips |
EP4076417A4 (en) * | 2019-12-20 | 2024-02-21 | Oye Therapeutics Inc | Caffeine citrate formulations |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4765983A (en) * | 1985-06-05 | 1988-08-23 | Yamanouchi Pharmaceutical Co., Ltd. | Adhesive medical tapes for oral mucosa |
US5085865A (en) * | 1989-04-12 | 1992-02-04 | Warner-Lambert Company | Sustained release pharmaceutical preparations containing an analgesic and a decongestant |
US5393528A (en) * | 1992-05-07 | 1995-02-28 | Staab; Robert J. | Dissolvable device for contraception or delivery of medication |
WO1996041617A1 (en) * | 1995-06-09 | 1996-12-27 | Apr Applied Pharma Research S.A. | Solid pharmaceutical form for oral use |
US5681583A (en) * | 1993-07-09 | 1997-10-28 | Apr Applied Pharma Research Sa | Multilayered controlled-release oral solid pharmaceutical forms |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4713243A (en) * | 1986-06-16 | 1987-12-15 | Johnson & Johnson Products, Inc. | Bioadhesive extruded film for intra-oral drug delivery and process |
JPH01279838A (en) * | 1988-04-30 | 1989-11-10 | Kiyuukiyuu Yakuhin Kogyo Kk | Lysozyme chloride-containing plaster for gingivitis and pyorrhea |
US4985467A (en) * | 1989-04-12 | 1991-01-15 | Scotfoam Corporation | Highly absorbent polyurethane foam |
KR100274734B1 (en) * | 1991-11-22 | 2000-12-15 | 제이코버스 코넬리스 레이서 | Risedronate delayed-release compositions |
EP0717761A4 (en) * | 1993-08-19 | 1998-01-07 | Cygnus Therapeutic Systems | Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavity |
JP3496727B2 (en) * | 1993-12-27 | 2004-02-16 | 救急薬品工業株式会社 | Pharmaceutical base |
JP3629283B2 (en) * | 1994-02-15 | 2005-03-16 | ポーラ化成工業株式会社 | Skin preparation |
DE19503336C2 (en) * | 1995-02-02 | 1998-07-30 | Lohmann Therapie Syst Lts | Pharmaceutical form for delivering active substances to wounds, process for their preparation and their use |
IT1282576B1 (en) * | 1996-02-06 | 1998-03-31 | Jagotec Ag | PHARMACEUTICAL TABLET SUITABLE TO GIVE THE ACTIVE SUBSTANCE IN SUBSEQUENT AND PREDETERMINABLE TIMES |
SE9603667D0 (en) * | 1996-10-08 | 1996-10-08 | Astra Ab | Pharmaceutical compositions |
ES2237104T3 (en) * | 1998-04-29 | 2005-07-16 | Virotex Corporation | CARRIER DEVICE FOR PHARMACEUTICAL PRODUCTS SUITABLE FOR THE CONTRIBUTION OF PHARMACEUTICAL COMPOUNDS TO MUCOUS SURFACES. |
US6277401B1 (en) * | 1999-05-07 | 2001-08-21 | U.S. Dermatologics, Inc. | Drug delivery device |
DE19954421A1 (en) * | 1999-11-12 | 2001-05-31 | Lohmann Therapie Syst Lts | Film-like preparation for the biphase release of pharmacologically active or other substances |
-
1999
- 1999-11-12 DE DE19954421A patent/DE19954421A1/en not_active Withdrawn
-
2000
- 2000-11-03 EP EP00975993A patent/EP1227802B1/en not_active Expired - Lifetime
- 2000-11-03 WO PCT/EP2000/010861 patent/WO2001035934A1/en active IP Right Grant
- 2000-11-03 PT PT00975993T patent/PT1227802E/en unknown
- 2000-11-03 CN CNB008167354A patent/CN100531724C/en not_active Expired - Lifetime
- 2000-11-03 ES ES00975993T patent/ES2260068T3/en not_active Expired - Lifetime
- 2000-11-03 DK DK00975993T patent/DK1227802T3/en active
- 2000-11-03 AT AT05026782T patent/ATE465722T1/en active
- 2000-11-03 IL IL14957200A patent/IL149572A0/en active IP Right Grant
- 2000-11-03 EP EP05026782A patent/EP1634587B1/en not_active Expired - Lifetime
- 2000-11-03 JP JP2001537927A patent/JP4825385B2/en not_active Expired - Fee Related
- 2000-11-03 KR KR1020027006105A patent/KR100677837B1/en active IP Right Grant
- 2000-11-03 AU AU13916/01A patent/AU777870B2/en not_active Expired
- 2000-11-03 AT AT00975993T patent/ATE320245T1/en active
- 2000-11-03 DE DE50015917T patent/DE50015917D1/en not_active Expired - Lifetime
- 2000-11-03 ES ES05026782T patent/ES2344954T3/en not_active Expired - Lifetime
- 2000-11-03 CA CA002391393A patent/CA2391393C/en not_active Expired - Lifetime
- 2000-11-03 DE DE50012412T patent/DE50012412D1/en not_active Expired - Lifetime
- 2000-11-03 US US10/129,837 patent/US7037526B1/en not_active Expired - Lifetime
-
2002
- 2002-05-09 IL IL149572A patent/IL149572A/en unknown
-
2006
- 2006-04-24 US US11/408,958 patent/US9084731B2/en not_active Expired - Fee Related
- 2006-06-14 CY CY20061100798T patent/CY1105051T1/en unknown
-
2011
- 2011-03-09 JP JP2011051364A patent/JP2011144193A/en active Pending
-
2015
- 2015-06-17 US US14/742,171 patent/US9211267B2/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4765983A (en) * | 1985-06-05 | 1988-08-23 | Yamanouchi Pharmaceutical Co., Ltd. | Adhesive medical tapes for oral mucosa |
US5085865A (en) * | 1989-04-12 | 1992-02-04 | Warner-Lambert Company | Sustained release pharmaceutical preparations containing an analgesic and a decongestant |
US5393528A (en) * | 1992-05-07 | 1995-02-28 | Staab; Robert J. | Dissolvable device for contraception or delivery of medication |
US5681583A (en) * | 1993-07-09 | 1997-10-28 | Apr Applied Pharma Research Sa | Multilayered controlled-release oral solid pharmaceutical forms |
WO1996041617A1 (en) * | 1995-06-09 | 1996-12-27 | Apr Applied Pharma Research S.A. | Solid pharmaceutical form for oral use |
Also Published As
Publication number | Publication date |
---|---|
KR100677837B1 (en) | 2007-02-05 |
DE50012412D1 (en) | 2006-05-11 |
US20060198878A1 (en) | 2006-09-07 |
JP2003514009A (en) | 2003-04-15 |
JP4825385B2 (en) | 2011-11-30 |
DE19954421A1 (en) | 2001-05-31 |
IL149572A (en) | 2007-08-19 |
US9211267B2 (en) | 2015-12-15 |
ES2260068T3 (en) | 2006-11-01 |
EP1634587A2 (en) | 2006-03-15 |
ATE465722T1 (en) | 2010-05-15 |
JP2011144193A (en) | 2011-07-28 |
IL149572A0 (en) | 2002-11-10 |
KR20020058008A (en) | 2002-07-12 |
DK1227802T3 (en) | 2006-07-24 |
CN100531724C (en) | 2009-08-26 |
CA2391393C (en) | 2008-07-15 |
DE50015917D1 (en) | 2010-06-10 |
EP1227802A1 (en) | 2002-08-07 |
ATE320245T1 (en) | 2006-04-15 |
US9084731B2 (en) | 2015-07-21 |
US20150272904A1 (en) | 2015-10-01 |
ES2344954T3 (en) | 2010-09-10 |
AU1391601A (en) | 2001-05-30 |
WO2001035934A1 (en) | 2001-05-25 |
CA2391393A1 (en) | 2001-05-25 |
EP1634587B1 (en) | 2010-04-28 |
PT1227802E (en) | 2006-08-31 |
CY1105051T1 (en) | 2009-11-04 |
AU777870B2 (en) | 2004-11-04 |
EP1227802B1 (en) | 2006-03-15 |
US7037526B1 (en) | 2006-05-02 |
CN1407888A (en) | 2003-04-02 |
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