EP0746315A4 - Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation - Google Patents

Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation

Info

Publication number
EP0746315A4
EP0746315A4 EP93920350A EP93920350A EP0746315A4 EP 0746315 A4 EP0746315 A4 EP 0746315A4 EP 93920350 A EP93920350 A EP 93920350A EP 93920350 A EP93920350 A EP 93920350A EP 0746315 A4 EP0746315 A4 EP 0746315A4
Authority
EP
European Patent Office
Prior art keywords
carbazolyl
inhibition
treatment
cell proliferation
smooth muscle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93920350A
Other languages
German (de)
French (fr)
Other versions
EP0746315A1 (en
Inventor
Eliot H Ohlstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BOEHRINGER MANNHEIM PHARMACEUTICALS CORPORATION-SMITHKLINE BEECHAM Corp NO 1 LP
Roche Diagnostics Corp
Original Assignee
BOEHRINGER MANNHEIM PHARMACEUTICALS CORPORATION-SMITHKLINE BEECHAM Corp NO 1 LP
Boehringer Mannheim Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/026,892 external-priority patent/US5308862A/en
Application filed by BOEHRINGER MANNHEIM PHARMACEUTICALS CORPORATION-SMITHKLINE BEECHAM Corp NO 1 LP, Boehringer Mannheim Pharmaceuticals Corp filed Critical BOEHRINGER MANNHEIM PHARMACEUTICALS CORPORATION-SMITHKLINE BEECHAM Corp NO 1 LP
Publication of EP0746315A1 publication Critical patent/EP0746315A1/en
Publication of EP0746315A4 publication Critical patent/EP0746315A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
EP93920350A 1993-03-05 1993-08-27 Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation Withdrawn EP0746315A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/US1993/002062 WO1994020096A1 (en) 1993-03-05 1993-03-05 Method of employing carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation
US26892 1993-03-05
WOPCT/US93/02062 1993-03-05
US08/026,892 US5308862A (en) 1993-03-05 1993-03-05 Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation
PCT/US1993/008019 WO1994020097A1 (en) 1993-03-05 1993-08-27 Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation

Publications (2)

Publication Number Publication Date
EP0746315A1 EP0746315A1 (en) 1996-12-11
EP0746315A4 true EP0746315A4 (en) 1999-01-07

Family

ID=26701782

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93920350A Withdrawn EP0746315A4 (en) 1993-03-05 1993-08-27 Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation

Country Status (7)

Country Link
EP (1) EP0746315A4 (en)
JP (1) JPH08508013A (en)
AU (1) AU679462B2 (en)
NO (1) NO307865B1 (en)
RU (1) RU2147433C1 (en)
UA (1) UA41915C2 (en)
WO (2) WO1994020096A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4503067A (en) * 1978-04-13 1985-03-05 Boehringer Mannheim Gmbh Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3319027A1 (en) * 1983-05-26 1984-11-29 Boehringer Mannheim Gmbh, 6800 Mannheim METHOD FOR PRODUCING OPTICALLY ACTIVE CARBAZOL DERIVATIVES, NEW R- AND S-CARBAZOL DERIVATIVES, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4970227A (en) * 1984-11-20 1990-11-13 Burroughs Wellcome Co. Carbazole derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4503067A (en) * 1978-04-13 1985-03-05 Boehringer Mannheim Gmbh Carbazolyl-(4)-oxypropanolamine compounds and therapeutic compositions

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MCTAVISH D ET AL: "CARVEDILOL A REVIEW OF ITS PHAMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, ANDTHERAPEUTIC EFFICACY", DRUGS, vol. 45, no. 2, 1 February 1993 (1993-02-01), pages 232 - 258, XP000578564 *
RUFFOLO R R ET AL: "CARVEDILOL: A NOVEL CARDIOVASCULAR DRUG WITH MULTIPLE ACTIONS", CARDIOVASCULAR DRUG REVIEWS, vol. 10, no. 2, 1 January 1992 (1992-01-01), pages 127 - 157, XP000578562 *
See also references of WO9420097A1 *

Also Published As

Publication number Publication date
WO1994020096A1 (en) 1994-09-15
UA41915C2 (en) 2001-10-15
NO307865B1 (en) 2000-06-13
EP0746315A1 (en) 1996-12-11
NO953480D0 (en) 1995-09-04
WO1994020097A1 (en) 1994-09-15
AU5092393A (en) 1994-09-26
JPH08508013A (en) 1996-08-27
RU2147433C1 (en) 2000-04-20
NO953480L (en) 1995-11-03
AU679462B2 (en) 1997-07-03

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