DE69934781D1 - Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen - Google Patents

Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen

Info

Publication number
DE69934781D1
DE69934781D1 DE69934781T DE69934781T DE69934781D1 DE 69934781 D1 DE69934781 D1 DE 69934781D1 DE 69934781 T DE69934781 T DE 69934781T DE 69934781 T DE69934781 T DE 69934781T DE 69934781 D1 DE69934781 D1 DE 69934781D1
Authority
DE
Germany
Prior art keywords
morphinsulfate
microgranulates
preparation
pharmaceutical compositions
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69934781T
Other languages
English (en)
Other versions
DE69934781T2 (de
Inventor
Patrice Debregeas
Gerard Leduc
Pascal Oury
Pascal Suplie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethypharm SAS
Original Assignee
Ethypharm SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm SAS filed Critical Ethypharm SAS
Application granted granted Critical
Publication of DE69934781D1 publication Critical patent/DE69934781D1/de
Publication of DE69934781T2 publication Critical patent/DE69934781T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
DE69934781T 1998-02-16 1999-02-15 Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen Expired - Lifetime DE69934781T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9801816 1998-02-16
FR9801816A FR2774910B1 (fr) 1998-02-16 1998-02-16 Microgranules de sulfate de morphine, procede de fabrication et preparations pharmaceutiques
PCT/FR1999/000326 WO1999040918A1 (fr) 1998-02-16 1999-02-15 Microgranules de sulfate de morphine, procede de fabrication et preparations pharmaceutiques

Publications (2)

Publication Number Publication Date
DE69934781D1 true DE69934781D1 (de) 2007-02-22
DE69934781T2 DE69934781T2 (de) 2007-10-11

Family

ID=9522990

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69934781T Expired - Lifetime DE69934781T2 (de) 1998-02-16 1999-02-15 Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen

Country Status (16)

Country Link
US (2) US6482437B2 (de)
EP (1) EP1054672B1 (de)
JP (1) JP4447166B2 (de)
CN (1) CN1135981C (de)
AU (1) AU2429899A (de)
BR (1) BR9907908A (de)
CA (1) CA2320878C (de)
CY (1) CY1107559T1 (de)
DE (1) DE69934781T2 (de)
DK (1) DK1054672T3 (de)
ES (1) ES2277427T3 (de)
FR (1) FR2774910B1 (de)
HK (1) HK1036402A1 (de)
NZ (1) NZ506307A (de)
PT (1) PT1054672E (de)
WO (1) WO1999040918A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790668B1 (fr) * 1999-03-12 2002-07-26 D B F Granules contenant une substance vegetale et leur procede de preparation
US20040253310A1 (en) 2001-09-21 2004-12-16 Gina Fischer Morphine polymer release system
US20040234602A1 (en) 2001-09-21 2004-11-25 Gina Fischer Polymer release system
ATE495732T1 (de) 2003-03-26 2011-02-15 Egalet As Morphin-system mit kontrollierter freisetzung
CN1874764B (zh) * 2003-10-10 2012-08-01 埃法尔姆公司 含有银杏提取物的持续释放微粒及其制备方法
FR2883179B1 (fr) 2005-03-18 2009-04-17 Ethypharm Sa Comprime enrobe
US20070190141A1 (en) * 2006-02-16 2007-08-16 Aaron Dely Extended release opiate composition
US20100233257A1 (en) * 2006-06-09 2010-09-16 Ethypharm Low dose sublingual tablets of opioid analgesics and preparation process
US20070286900A1 (en) * 2006-06-09 2007-12-13 Catherine Herry Low dose tablets of opioid analgesics and preparation process
EP2155167A2 (de) 2007-06-04 2010-02-24 Egalet A/S Pharmazeutische zusammensetzungen mit gesteuerter freisetzung für verlängerte wirkung
AU2008296971B2 (en) * 2007-09-03 2014-10-02 Nanoshift, Llc Particulate compositions for delivery of poorly soluble drugs
NZ594207A (en) 2009-02-06 2013-03-28 Egalet Ltd Immediate release composition resistant to abuse by intake of alcohol
NZ603579A (en) 2009-06-24 2014-02-28 Egalet Ltd Controlled release formulations
CA2877183A1 (en) 2012-07-06 2014-01-09 Egalet Ltd. Abuse deterrent pharmaceutical compositions for controlled release
US9683448B2 (en) 2013-03-18 2017-06-20 Honeywell International Inc. Low conductivity thermal barrier coating
US11479846B2 (en) 2014-01-07 2022-10-25 Honeywell International Inc. Thermal barrier coatings for turbine engine components

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4142526A (en) * 1974-12-23 1979-03-06 Alza Corporation Osmotic releasing system with means for changing release therefrom
US4309996A (en) * 1980-04-28 1982-01-12 Alza Corporation System with microporous releasing diffusor
US4673405A (en) * 1983-03-04 1987-06-16 Alza Corporation Osmotic system with instant drug availability
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
DE3708856A1 (de) 1987-03-18 1988-09-29 Kajetan Leitner Mit zaehnen versehene einpressmutter
US5202128A (en) * 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5891471A (en) * 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
US5411745A (en) * 1994-05-25 1995-05-02 Euro-Celtique, S.A. Powder-layered morphine sulfate formulations
US5582838A (en) * 1994-12-22 1996-12-10 Merck & Co., Inc. Controlled release drug suspension delivery device
US6066339A (en) * 1997-10-17 2000-05-23 Elan Corporation, Plc Oral morphine multiparticulate formulation

Also Published As

Publication number Publication date
NZ506307A (en) 2003-11-28
US6482437B2 (en) 2002-11-19
DE69934781T2 (de) 2007-10-11
DK1054672T3 (da) 2007-04-10
PT1054672E (pt) 2007-04-30
AU2429899A (en) 1999-08-30
JP2002502877A (ja) 2002-01-29
BR9907908A (pt) 2002-04-30
CN1291097A (zh) 2001-04-11
US20030129244A1 (en) 2003-07-10
JP4447166B2 (ja) 2010-04-07
EP1054672B1 (de) 2007-01-10
FR2774910B1 (fr) 2001-09-07
CN1135981C (zh) 2004-01-28
CY1107559T1 (el) 2013-03-13
EP1054672A1 (de) 2000-11-29
CA2320878C (fr) 2009-04-21
CA2320878A1 (fr) 1999-08-19
ES2277427T3 (es) 2007-07-01
US20020028246A1 (en) 2002-03-07
HK1036402A1 (en) 2002-01-04
FR2774910A1 (fr) 1999-08-20
WO1999040918A1 (fr) 1999-08-19

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