DE60045695D1 - Hydromorphinonzusammensetzungen - Google Patents

Hydromorphinonzusammensetzungen

Info

Publication number
DE60045695D1
DE60045695D1 DE60045695T DE60045695T DE60045695D1 DE 60045695 D1 DE60045695 D1 DE 60045695D1 DE 60045695 T DE60045695 T DE 60045695T DE 60045695 T DE60045695 T DE 60045695T DE 60045695 D1 DE60045695 D1 DE 60045695D1
Authority
DE
Germany
Prior art keywords
hydromorphone
hydroxy
dihydromorphone
salt
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60045695T
Other languages
English (en)
Inventor
William H Harclerode
Robert Gault
Mark D Sandison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27389009&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60045695(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of DE60045695D1 publication Critical patent/DE60045695D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
DE60045695T 1999-11-09 2000-11-09 Hydromorphinonzusammensetzungen Expired - Lifetime DE60045695D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16450599P 1999-11-09 1999-11-09
US16453699P 1999-11-09 1999-11-09
US16436499P 1999-11-09 1999-11-09

Publications (1)

Publication Number Publication Date
DE60045695D1 true DE60045695D1 (de) 2011-04-14

Family

ID=27389009

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60045695T Expired - Lifetime DE60045695D1 (de) 1999-11-09 2000-11-09 Hydromorphinonzusammensetzungen
DE60039711T Expired - Lifetime DE60039711D1 (en) 1999-11-09 2000-11-09 Hydromorphinone and hydrocodeinone compositions and methods for their synthesis

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60039711T Expired - Lifetime DE60039711D1 (en) 1999-11-09 2000-11-09 Hydromorphinone and hydrocodeinone compositions and methods for their synthesis

Country Status (10)

Country Link
US (2) US6512117B1 (de)
EP (3) EP2003134B1 (de)
JP (1) JP4886953B2 (de)
AT (2) ATE402937T1 (de)
AU (1) AU1595701A (de)
CA (3) CA2389193A1 (de)
DE (2) DE60045695D1 (de)
ES (1) ES2309001T5 (de)
MX (1) MXPA02004678A (de)
WO (1) WO2001034608A1 (de)

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EP2295043A1 (de) 1999-10-29 2011-03-16 Euro-Celtique S.A. Hydrocodon-Formulierungen mit gesteuerter Freisetzung
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
CN101317825A (zh) 2000-10-30 2008-12-10 欧罗赛铁克股份有限公司 控释氢可酮制剂
US7323565B2 (en) 2002-11-11 2008-01-29 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
US7321038B2 (en) 2002-11-11 2008-01-22 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
WO2005016930A2 (en) * 2003-08-08 2005-02-24 Euro-Celtique, S.A. Methods for detecting morphinone
SK286047B6 (sk) * 2004-04-13 2008-01-07 Zentiva, A. S. Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
US6946556B1 (en) * 2004-05-21 2005-09-20 Acura Pharmaceuticals, Inc. Preparation of opioid analgesics by a one-pot process
US7348430B2 (en) 2005-01-21 2008-03-25 Acura Pharmaceuticals, Inc. Production of opioid analgesics
WO2006104656A1 (en) * 2005-03-28 2006-10-05 Mallinckrodt Inc. Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof
JP2008536934A (ja) * 2005-04-18 2008-09-11 ノランコ・インコーポレーテツド ヒドロモルホン多形体
US20100073766A1 (en) * 2005-10-26 2010-03-25 Angros Lee H Microscope slide testing and identification assembly
US20080069891A1 (en) 2006-09-15 2008-03-20 Cima Labs, Inc. Abuse resistant drug formulation
US8445018B2 (en) 2006-09-15 2013-05-21 Cima Labs Inc. Abuse resistant drug formulation
US7399859B1 (en) 2007-02-06 2008-07-15 Cody Laboratories Inc. Method for catalytic preparation of hydromorphone and hydrocodone
US20080206883A1 (en) * 2007-02-26 2008-08-28 Cody Laboratories, Inc. Hplc method for separation and detection of hydromorphone and related opioid pharmacophores
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
US7999104B2 (en) 2007-06-29 2011-08-16 Brock University Methods for one-pot N-demethylation/N-acylation of morphine and tropane alkaloids
US9226907B2 (en) 2008-02-01 2016-01-05 Abbvie Inc. Extended release hydrocodone acetaminophen and related methods and uses thereof
GB0802351D0 (en) * 2008-02-08 2008-03-12 Owen Mumford Ltd Injection devices
US9040705B2 (en) * 2009-04-09 2015-05-26 Mallinckrodt Llc Preparation of saturated ketone morphinan compounds
US20100261906A1 (en) * 2009-04-09 2010-10-14 Mallinckrodt Inc. Preparation of 6-Keto, 3-Alkoxy Morphinans
EP2417139B1 (de) * 2009-04-09 2016-03-23 Mallinckrodt LLC Herstellung gesättigter ketonmorphinanverbindungen durch katalytische isomerisierung
WO2011035276A2 (en) 2009-09-21 2011-03-24 Mallinckrodt Inc. Heterogeneous ruthenium metal catalyst for the production of hydrocodone, hydromorphone or a derivative thereof
MX2012012991A (es) 2010-05-11 2012-11-30 Cima Labs Inc Formas de dosificacion oral de liberacion prolongada resistentes al alcohol y que contienen metoprolol.
EP2705040B1 (de) 2011-05-06 2016-12-07 Brock University Verfahren zur herstellung von morphinanalogen durch metallkatalysierte n-demethylierung/-funktionalisierung und intramolekulare gruppenübertragung
TWI560170B (en) * 2011-12-06 2016-12-01 Lundbeck & Co As H Process for recovery of nalmefene hydrochloride
US9155734B2 (en) 2012-03-07 2015-10-13 Mallinckrodt Llc Stability of hydromorphone hydrochloride solutions
CN103408553B (zh) * 2013-08-20 2016-02-03 宜昌人福药业有限责任公司 一种氢吗啡酮酸式盐的精制工艺
EP3102576B8 (de) 2014-02-03 2019-06-19 Vitae Pharmaceuticals, LLC Dihydropyrrolopyridininhibitoren von ror-gamma
UA118989C2 (uk) 2014-10-14 2019-04-10 Вітае Фармасьютікалс, Інк. Дигідропіролопіридинові інгібітори ror-гамма
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
US10301261B2 (en) 2015-08-05 2019-05-28 Vitae Pharmaceuticals, Llc Substituted indoles as modulators of ROR-gamma
CA3005658A1 (en) 2015-11-20 2017-05-26 Vitae Pharmaceuticals, Inc. Modulators of ror-gamma
TWI757266B (zh) 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2018009856A1 (en) 2016-07-08 2018-01-11 Cody Laboratories, Inc. Method for catalytic preparation of hydromorphone, hydrocodone and other opiates
CN115650976A (zh) 2017-07-24 2023-01-31 生命医药有限责任公司 RORγ的抑制剂
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
CN108164540B (zh) * 2017-12-14 2019-08-13 宜昌人福药业有限责任公司 一种合成氢吗啡酮的方法
JP2023548356A (ja) * 2020-11-02 2023-11-16 ローズ テクノロジーズ ノルオキシモルホンを精製するための方法
WO2022101408A1 (en) 2020-11-13 2022-05-19 Ferrer Internacional, S.A. Synthesis of hydromorphone base

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB285404A (de)
DE260233C (de)
DE365683C (de) 1921-03-22 1922-12-22 Knoll & Co Chem Fab Verfahren zur Darstellung von Ketoderivaten der Morphinreihe
DE607931C (de) 1934-01-26 1935-01-11 Chemische Fabriken Verfahren zur Darstellung von Dihydromorphinonen
US2544291A (en) 1949-04-05 1951-03-06 New York Quinine And Chemical Alkaloid manufacture
US2654756A (en) * 1949-10-20 1953-10-06 Mallinckrodt Chemical Works Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
US2628962A (en) 1949-10-20 1953-02-17 Mallinckrodt Chemical Works Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone
US2649454A (en) 1951-08-20 1953-08-18 Univ California Method for preparing dihydromorphinone, dihydrocodeinone, and dihydropseudocodeinone
GB9616253D0 (en) * 1996-08-01 1996-09-11 Johnson Matthey Plc Preparation of narcotic analgesics

Also Published As

Publication number Publication date
EP2003134B1 (de) 2011-03-02
EP2003134A2 (de) 2008-12-17
CA2854796A1 (en) 2001-05-17
ES2309001T5 (es) 2011-12-28
WO2001034608A1 (en) 2001-05-17
CA2674424C (en) 2012-10-02
DE60039711D1 (en) 2008-09-11
US6512117B1 (en) 2003-01-28
EP2338891A2 (de) 2011-06-29
EP1233966A1 (de) 2002-08-28
US20030045720A1 (en) 2003-03-06
JP2003513980A (ja) 2003-04-15
ES2309001T3 (es) 2008-12-16
US6589960B2 (en) 2003-07-08
CA2674424A1 (en) 2001-05-17
ATE500257T1 (de) 2011-03-15
CA2389193A1 (en) 2001-05-17
ATE402937T1 (de) 2008-08-15
JP4886953B2 (ja) 2012-02-29
MXPA02004678A (es) 2005-10-05
EP2338891A3 (de) 2011-10-26
EP1233966B1 (de) 2008-07-30
AU1595701A (en) 2001-06-06
EP2003134A3 (de) 2009-02-25
EP1233966B2 (de) 2011-10-19

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