DE29724755U1 - Sofortige Benetzbarkeit aufweisende(r) wasserlöslicher Film oder wasserlösliche Schicht zur oralen Applikation - Google Patents
Sofortige Benetzbarkeit aufweisende(r) wasserlöslicher Film oder wasserlösliche Schicht zur oralen ApplikationInfo
- Publication number
- DE29724755U1 DE29724755U1 DE29724755U DE29724755U DE29724755U1 DE 29724755 U1 DE29724755 U1 DE 29724755U1 DE 29724755 U DE29724755 U DE 29724755U DE 29724755 U DE29724755 U DE 29724755U DE 29724755 U1 DE29724755 U1 DE 29724755U1
- Authority
- DE
- Germany
- Prior art keywords
- film according
- water
- layer film
- content
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/90—Block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Description
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Claims (12)
1. Einschichtiger Film bestehend aus einer mucoadhäsiven Zubereitung enthaltend
- a) mindestens ein wasserlösliches Polymer,
- b) einen oberflächenaktiven Stoff allein oder
- c) einen oberflächenaktiven Stoff zusammen mit mindestens einem Stoff aus der Gruppe Polyalkohle und Weichmacher, oder
- d) einen Polyalkohol und einen Weichmacher,
- e) mindestens einen kosmetischen oder pharmazeutischen Wirkstoff, und
- f) einen Geschmacks-, Aroma- oder Duftstoff,
2. Einschichtiger Film gemäß Anspruch 1, dadurch gekennzeichnet, dass die Dicke
des Films im trockenen Zustand ungefähr 70 µm beträgt.
3. Einschichtiger Film gemäß Anspruch 1 oder 2, dadurch gekennzeichnet, dass der
Gehalt des wasserlöslichen Polymers zwischen 20 und 75 Gew.-%, der Gehalt
des oberflächenaktiven Stoffes zwischen 0,1 und 5 Gew.-%, der Gehalt des
Polyalkohols zwischen 0,1 und 5 Gew.-% und der Gehalt des kosmetischen oder
pharmazeutischen Wirkstoffs sowie des Geschmacks-, Aroma- oder Duftstoffs
zwischen 0,01 und 20 Gew.-% beträgt.
4. Einschichtiger Film gemäß Anspruch 1, dadurch gekennzeichnet, dass das
wasserlösliche Polymer ausgewählt ist aus der Gruppe bestehend aus Hydroxy
propylmethylcellusose, Hydroxyethylcellulose, Hydroxypropylcellulose,
Polyvinylpyrrolidon, Carboxylmethylcellulose, Polyvinylalkohol, Natriumalginat,
Polyethylenglycol, Xanthanharz, Traganth, Guarharz, Akazienharz,
Gummiarabicum, Polyacrylsäure, Methylmethacrylatcopolymer,
Carboxyvinylcopolymere und einer Mischung der genannten Polymere.
5. Einschichtiger Film gemäß Anspruch 1, dadurch gekennzeichnet, dass der Gehalt
des wasserlöslichen Polymers zwischen 20 und 75 Gew.-% beträgt.
6. Einschichtiger Film gemäß Anspruch 1, dadurch gekennzeichnet, dass der Poly
alkohol ausgewählt ist aus der Gruppe bestehend aus Glycerin, Polyethylen
glycol, Propylenglycol und Glycerinfettsäuremonoester.
7. Einschichtiger Film gemäß Anspruch 1, dadurch gekennzeichnet, dass die muko
adhäsive Zubereitung einen Polyalkohol und einen oberflächenaktiven Stoff
enthält.
8. Einschichtiger Film gemäß Anspruch 1, dadurch gekennzeichnet, dass der ober
flächenaktive Stoff ausgewählt ist aus einer Gruppe bestehend aus
Polyethoxysorbitanfettsäureester, α-Hydroxy-ω-hydroxypoly(ethoxy)-
poly(propoxy)-poly (ethoxy)-Blockcopolymer, Polyethoxyalkylether,
Polyethoxyrizinusöl-Derivat und eine Mischung der genannten Stoffe.
9. Einschichtiger Film gemäß Anspruch 1, dadurch gekennzeichnet, dass die muko
adhäsive Zubereitung Sorbit und/oder Polyvinylpyrrolidon zusammen mit einem
wasserlöslichen polymeren Cellulose-Derivat enthält.
10. Einschichtiger Film gemäß Anspruch 1, dadurch gekennzeichnet, dass der thera
peutische Wirkstoff ausgewählt ist, aus der Gruppe bestehend aus Hypnotica,
Sedativa, Antiepileptica, Weckaminen, Psychoneurotropica, Neuro-
Muskelblockern, Antispasmodica, Antihistaminica, Antiallergica, Cardiotonica,
Antiarrhythmica, Diuretica, Hypotensiva, Vasopressoren, Antitussiva,
Expectorantia, Thyroidhormonen, Sexualhormonen, Antidiabetica, Antitumor-
Wirkstoffen, Antibiotica, Chemotherapeutica und Narcotica.
11. Einschichtiger Film gemäß Anspruch 1, dadurch gekennzeichnet, dass der kos
metische Wirkstoff ein Atemerfrischer, der geeignet für die Mundhygiene ist, ein
Wirkstoff zur Zahn- oder Mundpflege oder eine Mischung der genannten Stoffe
ist.
12. Einschichtiger Film gemäß Anspruch 1, gekennzeichnet durch eine Form, die für
die Anwendung im Mund geeignet ist.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE29724755U DE29724755U1 (de) | 1996-11-11 | 1997-10-22 | Sofortige Benetzbarkeit aufweisende(r) wasserlöslicher Film oder wasserlösliche Schicht zur oralen Applikation |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19646392A DE19646392A1 (de) | 1996-11-11 | 1996-11-11 | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
DE29724755U DE29724755U1 (de) | 1996-11-11 | 1997-10-22 | Sofortige Benetzbarkeit aufweisende(r) wasserlöslicher Film oder wasserlösliche Schicht zur oralen Applikation |
EP97911237A EP0936905B1 (de) | 1996-11-11 | 1997-10-22 | Sofortige benetzbarkeit aufweisende(r) wasserlöslicher film oder wasserlösliche schicht zur oralen applikation |
Publications (1)
Publication Number | Publication Date |
---|---|
DE29724755U1 true DE29724755U1 (de) | 2003-10-02 |
Family
ID=7811214
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19646392A Withdrawn DE19646392A1 (de) | 1996-11-11 | 1996-11-11 | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
DE59712993T Expired - Lifetime DE59712993D1 (de) | 1996-11-11 | 1997-10-22 | Sofortige Benetzbarkeit aufweisende(r) wasserlöslicher Film oder wasserlösliche Schicht zur oralen Applikation |
DE59710670T Expired - Lifetime DE59710670D1 (de) | 1996-11-11 | 1997-10-22 | Sofortige benetzbarkeit aufweisende(r) wasserlöslicher film oder wasserlösliche schicht zur oralen applikation |
DE29724755U Expired - Lifetime DE29724755U1 (de) | 1996-11-11 | 1997-10-22 | Sofortige Benetzbarkeit aufweisende(r) wasserlöslicher Film oder wasserlösliche Schicht zur oralen Applikation |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19646392A Withdrawn DE19646392A1 (de) | 1996-11-11 | 1996-11-11 | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
DE59712993T Expired - Lifetime DE59712993D1 (de) | 1996-11-11 | 1997-10-22 | Sofortige Benetzbarkeit aufweisende(r) wasserlöslicher Film oder wasserlösliche Schicht zur oralen Applikation |
DE59710670T Expired - Lifetime DE59710670D1 (de) | 1996-11-11 | 1997-10-22 | Sofortige benetzbarkeit aufweisende(r) wasserlöslicher film oder wasserlösliche schicht zur oralen applikation |
Country Status (26)
Country | Link |
---|---|
US (8) | US5948430A (de) |
EP (2) | EP0936905B1 (de) |
JP (3) | JP4063331B2 (de) |
KR (2) | KR100569847B1 (de) |
AT (2) | ATE247954T1 (de) |
AU (1) | AU739698B2 (de) |
CA (1) | CA2265651C (de) |
CZ (1) | CZ297354B6 (de) |
DE (4) | DE19646392A1 (de) |
DK (2) | DK0936905T3 (de) |
ES (2) | ES2206692T3 (de) |
HK (1) | HK1035316A1 (de) |
HU (2) | HU228464B1 (de) |
ID (1) | ID22526A (de) |
IL (2) | IL129819A0 (de) |
MY (1) | MY125548A (de) |
NO (2) | NO325073B1 (de) |
NZ (1) | NZ335063A (de) |
PL (1) | PL190376B1 (de) |
PT (2) | PT936905E (de) |
SI (1) | SI0936905T1 (de) |
SK (2) | SK285999B6 (de) |
TR (1) | TR199901633T2 (de) |
TW (2) | TWI250029B (de) |
WO (1) | WO1998020862A1 (de) |
ZA (1) | ZA9710093B (de) |
Families Citing this family (388)
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DE19636001A1 (de) * | 1996-09-05 | 1998-03-12 | Hoechst Ag | Sulfoxidgruppenhaltige Polymermischungen |
US5800832A (en) * | 1996-10-18 | 1998-09-01 | Virotex Corporation | Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces |
DE19646392A1 (de) * | 1996-11-11 | 1998-05-14 | Lohmann Therapie Syst Lts | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
US20050048102A1 (en) * | 1997-10-16 | 2005-03-03 | Virotex Corporation | Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces |
DE19832169A1 (de) * | 1998-07-17 | 2000-01-27 | Jenapharm Gmbh | Lokal anwendbare pharmazeutische Präparate zur Prophylaxe und Therapie atrophischer Erscheinungen in der Mundhöhle |
US20020098264A1 (en) * | 1998-11-27 | 2002-07-25 | Cherukuri Subraman R. | Medicated chewing gum delivery system for nicotine |
US6358060B2 (en) | 1998-09-03 | 2002-03-19 | Jsr Llc | Two-stage transmucosal medicine delivery system for symptom relief |
US20030206942A1 (en) * | 1998-09-25 | 2003-11-06 | Neema Kulkarni | Fast dissolving orally consumable films containing an antitussive and a mucosa coating agent |
US20030211136A1 (en) * | 1998-09-25 | 2003-11-13 | Neema Kulkarni | Fast dissolving orally consumable films containing a sweetener |
US6596298B2 (en) * | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
DK1135112T3 (da) * | 1998-11-27 | 2005-02-14 | Kanji Takada | Oral formulering til gastrointestinal lægemiddeladministration |
DE19856101A1 (de) * | 1998-12-04 | 2000-06-08 | Labtec Gmbh | Mundhöhlen-Matrixpflaster |
PT1139793E (pt) | 1998-12-23 | 2010-01-19 | Sinai School Medicine | Inibidores da resposta ao sabor amargo |
US6552024B1 (en) * | 1999-01-21 | 2003-04-22 | Lavipharm Laboratories Inc. | Compositions and methods for mucosal delivery |
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US7258869B1 (en) | 1999-02-08 | 2007-08-21 | Alza Corporation | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
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US6231957B1 (en) * | 1999-05-06 | 2001-05-15 | Horst G. Zerbe | Rapidly disintegrating flavor wafer for flavor enrichment |
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-
1996
- 1996-11-11 DE DE19646392A patent/DE19646392A1/de not_active Withdrawn
-
1997
- 1997-08-01 US US08/904,607 patent/US5948430A/en not_active Expired - Lifetime
- 1997-10-21 TW TW092105140A patent/TWI250029B/zh not_active IP Right Cessation
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- 1997-10-22 KR KR1020057014063A patent/KR100569847B1/ko active IP Right Grant
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- 1997-10-22 DE DE59712993T patent/DE59712993D1/de not_active Expired - Lifetime
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- 1997-10-22 CA CA002265651A patent/CA2265651C/en not_active Expired - Lifetime
- 1997-10-22 AT AT03014213T patent/ATE422157T1/de active
- 1997-10-22 DK DK03014213T patent/DK1362584T3/da active
- 1997-10-22 NZ NZ335063A patent/NZ335063A/xx not_active IP Right Cessation
- 1997-10-22 JP JP52208898A patent/JP4063331B2/ja not_active Expired - Lifetime
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- 1997-10-22 EP EP03014213A patent/EP1362584B1/de not_active Expired - Lifetime
- 1997-10-22 ES ES03014213T patent/ES2322699T3/es not_active Expired - Lifetime
- 1997-10-22 TR TR1999/01633T patent/TR199901633T2/xx unknown
- 1997-10-22 HU HU0500666A patent/HU230022B1/hu unknown
- 1997-10-22 SK SK5041-2005A patent/SK285999B6/sk not_active IP Right Cessation
- 1997-10-22 SK SK622-99A patent/SK285100B6/sk not_active IP Right Cessation
- 1997-11-10 ZA ZA9710093A patent/ZA9710093B/xx unknown
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1999
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2000
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- 2000-08-02 US US09/630,562 patent/US6284264B1/en not_active Expired - Lifetime
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2001
- 2001-08-13 US US09/927,327 patent/US20010046511A1/en not_active Abandoned
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2002
- 2002-05-14 US US10/143,962 patent/US6709671B2/en not_active Expired - Lifetime
- 2002-06-05 US US10/161,670 patent/US6592887B2/en not_active Expired - Lifetime
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2004
- 2004-02-05 US US10/771,388 patent/US8865202B2/en not_active Expired - Fee Related
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2005
- 2005-06-01 JP JP2005161714A patent/JP4817721B2/ja not_active Expired - Fee Related
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