CN102210764A - Application of sweet almond oil in preparing medicament for treating myocardial ischemia reperfusion injury - Google Patents
Application of sweet almond oil in preparing medicament for treating myocardial ischemia reperfusion injury Download PDFInfo
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- CN102210764A CN102210764A CN2011101436419A CN201110143641A CN102210764A CN 102210764 A CN102210764 A CN 102210764A CN 2011101436419 A CN2011101436419 A CN 2011101436419A CN 201110143641 A CN201110143641 A CN 201110143641A CN 102210764 A CN102210764 A CN 102210764A
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Abstract
The invention provides an application of sweet almond oil in preparing a medicament for treating myocardial ischemia reperfusion injury. The medicament for preventing and treating myocardial ischemia reperfusion injury is prepared from sweet almond oil as an active component and is used in the form of soft capsules which are prepared directly from sweet almond oil by a conventional preparation method of soft capsules. Shown by drug effect tests, the sweet almond oil is capable of improving the hypoxia tolerance of the myocardial tissues of rats, enhancing the tolerance of the myocardial tissues to ischemia reperfusion myocardial injury, improving the antioxidant ability of the myocardial tissues of rats with ischemia reperfusion, and reducing the extent of injury to the myocardial tissues of rats caused by ischemia reperfusion. The almond oil is a natural edible material with unsaturated fatty acid as a main active component, and can not generate toxic side effect on the body when taken in a certain dose range for a long term.
Description
Technical field
The invention belongs to the medicinal preparation technical field of the product that contains raw material or itself and not clear structure, be specifically related to derive from the material of plant.
Background technology
Semen pruni armeniacae oil is to extract a vegetable oil that obtains in the dry fruit of Rosaceae (Rosaceae) cherry Fructus Pruni (Prunus armeniaca L.).Semen pruni armeniacae oil is to use one of vegetable oil the most widely, is faint yellow, and it contains about 90% unsaturated fatty acid, wherein oleic acid 60%, and linoleic acid 30% can reduce the triglyceride in the blood of human body, enhance metabolism, to preventing cardiovascular and cerebrovascular disease and having protected the liver better action.In addition, Semen pruni armeniacae oil also contains needed by human nutrients such as a spot of vitamin E, continues to take, and not only is of value to the growth of cerebrovascular and intelligence, also balanced body hormonal system hypophysis cerebri, the renewal of promotion cell, slow down aging etc. is had special efficacy.Semen pruni armeniacae oil is used for the skin daily nursing, has the magical effect of skin moistening and beauty treatment, therefore is described as by people " natural plants gold ".
Jia Lingyun etc. have inquired into the effect of wild apricot almond oil to hyperlipemia rat liver, the heart, nephridial tissue antioxidant activity; the result shows wild Prunus armeniaca L.var.ansu Maxim. almond oil liver, the heart, the kidney of hyperlipemia rat to be had the anti-oxidation protection effect (almond oil is to experimental hyperlipemia rat Antioxidation Effects; Northwest Normal University's journal; natural science edition; 2008,4 (2): 92-98).Kong Hao measures almond oil and removes the ability of free radical and calculate corresponding IC50 value by setting up hydroxyl radical free radical, ultra-oxygen anion free radical removing system, the result shows, clearance rate can reach (almond oil and the capability study of Oleum Vitis viniferae removing free radical more than 60% when almond oil concentration is 0.1mg/mL, gansu science and technology, 2008,24 (6): 57-58).Wang Jianhuas etc. are organized 108 examples (with almond oil cotton balls vagina administration) and matched group 92 examples (using the interferon suppository vagina administration) by 200 routine patients of cervical ruin being divided at random treatment, 2 groups all treat 3 courses of treatment after, find that almond oil has the (clinical research of almond oil treatment cervical erosion of certain curative effect to cervical erosion, the Jiangxi Chinese medicine, 2006 (6): 32).The west of a river, the Tianjin Wang Wei of hospital has obtained promising result (skilful use almond oil treatment " yellow fluid bubble ", Tianjin nursing, 1996,12 (4): 167-168) with almond oil treatment " yellow fluid bubble " clinical observation 10 examples.Report is arranged, and almond oil has significant protective effect to carbon tetrachloride hepatic injury, and (FoodChem 2011; 125:673-678).
Cardiovascular disease has become first killer of harm humans health, along with the raising of people's living standard, the quickening of rhythm of life, the increasing of work life stress, the sickness rate of cardiovascular disease, mortality rate are obvious ascendant trend, serious harm human existence quality.Myocardial ischemia reperfusion injury is meant because of blood supply disorder and causes a kind of pathological process of recovering blood supply behind the myocardial ischemia again.The key of myocardial damage treatment is to alleviate the damage after the myocardium severe ischemic anoxia or strengthens the resistivity of myocardial cell to the hypoxic-ischemic damage.The medicine that is usually used in myocardial ischemia reperfusion injury can be divided into five classes: (1) anticoagulation medicine, as aspirin, warfarin; (2) coronary artery dilator class medicine is as nitric acid lipid, calcium ion antagonist; (3) beta-blocker is as atenolol, metoprolol; (4) adrenergic blocking agent is as metoprolol; (5) Folium Digitalis Purpureae class is as digoxin etc.; (6) other also has antihypertensive drug and blood sugar regulation, blood-lipoids medicine, as statins.But the use of these medicines all can produce certain side effect to health to a certain extent.
Summary of the invention
The present invention overcomes the shortcoming of above-mentioned treatment medicament for myocardial ischemia-reperfusion injury, for Semen pruni armeniacae oil provides a kind of new purposes from alleviating the damage after the myocardium severe ischemic anoxia or strengthening the resistivity of myocardial cell to the hypoxic-ischemic damage.
Solving the problems of the technologies described above the technical scheme that is adopted is: the purposes of Semen pruni armeniacae oil in preparation treatment medicament for myocardial ischemia-reperfusion injury.
The purposes of Semen pruni armeniacae oil in preparation myocardial damage protection medicine.
Semen pruni armeniacae oil is purchased the natural articles for use company limited in green fragrant island in the Guangzhou.Medicine with Semen pruni armeniacae oil preparation treatment myocardial ischemia reperfusion injury uses Semen pruni armeniacae oil with the form of soft capsule, described soft capsule is made according to the preparation technology of soft capsule routine, every heavy 0.8g of soft capsule.
Semen pruni armeniacae oil is with the usage and dosage of soft capsule: become human oral, each 12 of prevention myocardial damage dosage, every day 1 time, each 12 of treatment myocardial ischemia reperfusion injury dosage, every day 2 times.
Medicine of the present invention shows through the test of pesticide effectiveness; Semen pruni armeniacae oil is irritated rat myocardium from injury again to ischemia and is had the significant protection effect; can improve the hypoxia-bearing capability of rat heart muscle tissue; strengthen cardiac muscular tissue irritates myocardial damage again to ischemia tolerance; improve ischemia and irritate the oxidation resistance of rat heart muscle tissue again, the reduction ischemia is irritated the degree of injury to the rat heart muscle tissue again.Almond oil is to be the natural edible material of main effective ingredient with unsaturated fatty acid, in certain amount ranges, does not take for a long time and can cause toxic and side effects to health.
The specific embodiment
The present invention is described in more detail below in conjunction with embodiment, but the invention is not restricted to these embodiment.
Embodiment 1
With 1000 of production soft capsule products of the present invention is example, does not add any adjuvant, directly the 800g Semen pruni armeniacae oil is made soft capsule, every heavy 0.8g according to the conventional preparation technology of soft capsule.
Usage and dosage: become human oral, each 12 of preventive dose, every day 1 time, each 12 of therapeutic dose, every day 2 times.
In order to verify the beneficial effect of effective ingredient Semen pruni armeniacae oil treatment myocardial ischemia-reperfusion damage, the inventor has carried out the test of pesticide effectiveness with Semen pruni armeniacae oil, and concrete test situation is as follows:
Be subjected to the reagent thing: Semen pruni armeniacae oil, purchase the natural articles for use company limited in green fragrant island in the Guangzhou.
Experiment material: nitricoxide synthase (NOS), superoxide dismutase (SOD), catalase (CAT), glutathion peroxidase (GSH-Px), nitric oxide and malonaldehyde (MDA) testing cassete build up bio-engineering research by Nanjing to be provided.
Experimental apparatus: DF-101S heat collecting type heated at constant temperature magnetic stirring apparatus, produce by Zhengzhou Greatwall Scientific Industrial ﹠ Trading Co., Ltd.; HR-120 type precise electronic balance is produced by Japan; The BI-90Plus laser particle analyzer is produced by German Brooker Hai Wen instrument company; The TU-1810 ultraviolet-uisible spectrophotometer is produced by the Beijing Puxi General Instrument Co., Ltd; High speed low temperature centrifugal machine UNIVERSAL320R, Hettich-zentrifugen is produced by Germany.
Animal subject: healthy male SD rat, body weight 200～220g is provided by Xi'an Jiaotong University Medical College's Experimental Animal Center, and the animal quality certification moves word 08-005 number for the doctor; The rat solid feed is provided by Xi'an Jiaotong University Medical College's Experimental Animal Center, all experimental animal feeding term harmonizations.
1, laboratory animal and grouping
Healthy male SD rat is divided into sham operated rats, ischemia filling group more at random, dosage group, Semen pruni armeniacae oil high dose group in Semen pruni armeniacae oil low dose group, the Semen pruni armeniacae oil, every group each 12, adaptability is raised after 7 days and is experimentized.Before ischemia is irritated again, sham operated rats and ischemia filling group are again irritated the tap water of stomach 6mL/kg body weight every day, dosage group, Semen pruni armeniacae oil high dose group are irritated the Semen pruni armeniacae oil of stomach 2mL/kg, 6mL/kg, 10mL/kg body weight, continuous irrigation stomach 14 days every day respectively in Semen pruni armeniacae oil low dose group, the Semen pruni armeniacae oil.
2, model preparation
The 15th day be with mass fraction 5% pentobarbital sodium water solution by 30mg/kg body weight intraperitoneal anesthesia rat, dorsal position is fixed, and connects the toy respirator, opens breast in third and fourth intercostal space of left border of sternum and exposes heart, keeps pleura complete.That continues finds out left anterior descending coronary artery between pulmonary conus and left auricle, and places 2mm place ligation under the ramus descendens anterior arteriae coronariae sinistrae initial part, only not ligation of threading of sham operated rats with circular noinvasive sewing needle 4/0 silk thread sub-thread.With ECG T wave toweringly merge with the QRS ripple, the QRS ripple amplitude that broadens adds the greatly sign of ligation success.Ligation is unclamped ligature and was poured into 120 minutes again after 30 minutes.
3, detect index and method
Pour into 120 minutes again after coeliac artery is got blood, preparation serum, the activity of mensuration serum creatine kinase (CK) and glutamic oxaloacetic transaminase, GOT (AST).Get the complete heart of winning rapidly of blood, part is cleaned blood input liquid nitrogen with the ice normal saline and is preserved standby, measure nitricoxide synthase (NOS), superoxide dismutase (SOD), catalase (CAT), the activity of glutathion peroxidase (GSH-Px) and the content of nitric oxide (NO) and malonaldehyde (MDA), measurement result sees Table 1～4.The heart that part is won turns white from aortic arch cannula and with normal saline flushing to heart immediately, the reuse mass fraction is that 5% chloro triphenyltetrazolium chloride (TTC) aqueous solution pours into to heart and reddens, drop into liquid nitrogen immediately, taking out section after 20 minutes, to put mass fraction into be to fix 12 hours in 10% the formalin, the infarction position is pale asphyxia, and other positions are red, and blot with filter paper the back of taking pictures, separate the infarction position and weigh, calculate infarction and gross weight ratio.
Result of calculation sees Table 1.
4, statistical procedures
Each is organized data and represents that with mean+SD the significance degree of difference between each group is judged in employing t-check, uses the SPSS of statistical software deal with data.
5, experimental result and analysis
(1) Semen pruni armeniacae oil is to the influence of sero-enzyme activity and myocardial infarction degree
By table 1 as seen, ischemia filling group again serum CK and AST activity are apparently higher than sham operated rats (p＜0.05), and the rising amplitude is respectively 23.81% and 22.61%; The rat blood serum enzymatic activity of respectively organizing of taking Semen pruni armeniacae oil obviously reduces; significant difference (p＜0.05) is all arranged; along with the increase rat blood serum enzymatic activity of irritating stomach dosage has descended 7.69%, 35.90%, 82.05% respectively, illustrate that damage may have the certain protection effect to Semen pruni armeniacae oil to myocardial ischemia-reperfusion.
The TTC coloration result shows, dosage group, Semen pruni armeniacae oil high dose group rat myocardium from injury or infarction weight rate are respectively 5.14%, 20.41%, 19.65%, 14.60%, 7.35% in sham operated rats, ischemia filling group again, Semen pruni armeniacae oil low dose group, the Semen pruni armeniacae oil, ischemia filling group again weight ratio almost is 4 times of sham operated rats, take each group of Semen pruni armeniacae oil along with the rising infarction weight ratio of irritating stomach dosage reduces gradually, low dose group is compared with sham operated rats does not have significant difference (P＞0.05), the high dose group effect is the most obvious, has reduced nearly 3 times than ischemia filling group again.This experiment has further confirmed the protective effect of Semen pruni armeniacae oil to the myocardial ischemia-reperfusion damage.
Table 1 is respectively organized rat blood serum enzymatic activity and myocardial infarction weight rate
| Group | CK activity (U/ml) | AST activity (U/ml) | Infarction weight rate (%) |
| Sham operated rats | 0.63±0.08 | 44.68±3.94 | 5.14±0.37 |
| Ischemia filling group again | 0.78±0.10 ▲ | 54.78±2.40 ▲ | 20.41±1.04 ▲ |
| The Semen pruni armeniacae oil low dose group | 0.72±0.04 ▲ | 39.14±3.75 ★ | 19.65±0.60 ▲ |
| Dosage group in the Semen pruni armeniacae oil | 0.50±0.06 ▲★# | 39.86±2.43 ★ | 14.60±0.62 ▲★# |
| The Semen pruni armeniacae oil high dose group | 0.14±0.02 ▲#★＊ | 40.79±4.22 ★ | 7.35±0.43 ▲★#＊ |
In the table ▲ represent significant difference (P＜0.05) is arranged with sham operated rats; ★ represents with ischemia filling group again significant difference (P＜0.05) is arranged; # represents with the Semen pruni armeniacae oil low dose group significant difference (P＜0.05) is arranged; * the dosage group has significant difference (P＜0.05) in expression and the Semen pruni armeniacae oil.
(2) Semen pruni armeniacae oil is to the influence of myocardium CK and AST enzymatic activity
Table 2 is respectively organized rat heart muscle CK and AST enzymatic activity
In the table ▲ represent significant difference (P＜0.05) is arranged with sham operated rats; ★ represents with ischemia filling group again significant difference (P＜0.05) is arranged.
By table 2 as seen, ischemia irritates in the rear myocardium tissue that CK and AST enzymatic activity are all in rising trend again, and ascensional range is respectively 6.24% and 13.68%, and the AST enzymatic activity changes to compare with sham operated rats and has significant difference (P＜0.05).The active reason that raises of CK may be a kind of biological compensatory response that cardiac muscular tissue takes place in order to obtain more adenosine triphosphate under ischemia/anaerobic condition.In addition, under ischemia/anaerobic condition, aerobic metabolism is obstructed, cardiac muscular tissue also can obtain more adenosine triphosphate by glycolytic pathway, cause the accumulation of aerobic metabolism intermediate product α-Tong Wuersuan, α-Tong Wuersuan activates AST as the substrate of the catalytic transamination reaction of AST, makes the AST activity raise.The experiment of having taken Semen pruni armeniacae oil organizes respectively that rat heart muscle is organized CK and AST is active obviously descends, and comparing with ischemia filling group more all has significant difference (P＜0.05), but does not have tangible dose relationship.Illustrate that Semen pruni armeniacae oil can improve the hypoxia-bearing capability of rat heart muscle tissue, strengthen cardiac muscular tissue irritates myocardial damage again to ischemia tolerance.
(3) Semen pruni armeniacae oil is to the influence of myocardium activities of antioxidant enzymes and MDA content
Table 3 is respectively organized rat heart muscle SOD, CAT, GSH-Px enzymatic activity and MDA content
In the table ▲ represent significant difference (P＜0.05) is arranged with sham operated rats; ★ represents with ischemia filling group again significant difference (P＜0.05) is arranged.
By table 3 as seen, SOD, CAT and GSH-Px activity all have decline in various degree after ischemia is irritated again, MDA content has rising slightly, SOD compares with sham operated rats with the GSH-Px activity change has significant difference (P＜0.05), and CAT is active to compare there was no significant difference (P＞0.05) with the MDA changes of contents with sham operated rats.After taking Semen pruni armeniacae oil, several activities of antioxidant enzymes all have rising in various degree in the rat heart muscle tissue, but all do not present tangible dose-effect relationship.Wherein the SOD activity change of three kinds of dosage groups of Semen pruni armeniacae oil is compared with ischemia filling group more all has significant difference (P＜0.05), low, the middle dosage group of Semen pruni armeniacae oil GSH-Px activity change is compared with ischemia filling group more all has significant difference (P＜0.05), three kinds of dosage groups of Semen pruni armeniacae oil CAT activity change is the most obvious, and comparing with ischemia filling group again with sham operated rats all has significant difference (P＜0.05).Result of the test shows that Semen pruni armeniacae oil can improve the oxidation resistance that ischemia is irritated the rat heart muscle tissue again, and the reduction ischemia is irritated the degree of injury to the rat heart muscle tissue again.
(4) Semen pruni armeniacae oil is to the influence of myocardium NOS activity and NO content
Table 4 is respectively organized the active and NO content of rat NOS
In the table ▲ represent significant difference (P＜0.05) is arranged with sham operated rats; ★ represents with ischemia filling group again significant difference (P＜0.05) is arranged.
By table 4 as seen, ischemia irritates in the rear myocardium tissue that cNOS is active to descend again, and iNOS is active to rise, but with sham operated rats there was no significant difference (P＞0.05), NO content significantly reduces (P＜0.05); Active obviously rise (P＜0.05) of the cNOS of three kinds of dosage groups of Semen pruni armeniacae oil, the iNOS activity is on a declining curve, Semen pruni armeniacae oil low dose group and high dose group and ischemia filling group again have significant difference (P＜0.05), and each group of NO content all has significance rising (P＜0.05)., result of the test explanation, Semen pruni armeniacae oil is irritated the protective effect of myocardial damage of rat again to ischemia relevant with the blood vessel dilating effect of NO.
6, conclusion (of pressure testing)
Semen pruni armeniacae oil is irritated rat myocardium from injury again to ischemia and is had significant protection and therapeutical effect; it can improve the hypoxia-bearing capability of rat heart muscle tissue; strengthen cardiac muscular tissue irritates myocardial damage again to ischemia tolerance; improve ischemia and irritate the oxidation resistance of rat heart muscle tissue again, the reduction ischemia is irritated the degree of injury to the rat heart muscle tissue again.
Claims (2)
1. Semen pruni armeniacae oil is preparing the purposes for the treatment of in the medicament for myocardial ischemia-reperfusion injury.
2. the purposes of Semen pruni armeniacae oil in preparation myocardial damage protection medicine.
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| CN105395967A (en) * | 2015-11-30 | 2016-03-16 | 杨文灿 | Medicinal composition for treating myocardial ischemia |
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