CA2447807A1 - Abuse resistant pharmaceutical composition containing capsaicin - Google Patents

Abuse resistant pharmaceutical composition containing capsaicin Download PDF

Info

Publication number
CA2447807A1
CA2447807A1 CA002447807A CA2447807A CA2447807A1 CA 2447807 A1 CA2447807 A1 CA 2447807A1 CA 002447807 A CA002447807 A CA 002447807A CA 2447807 A CA2447807 A CA 2447807A CA 2447807 A1 CA2447807 A1 CA 2447807A1
Authority
CA
Canada
Prior art keywords
composition
pharmaceutical composition
capsaicin
composition containing
abuse resistant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002447807A
Other languages
French (fr)
Other versions
CA2447807C (en
Inventor
Michael Goldberg
Bradley Stuart Galer
Huai-Hung Kao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Endo Pharmaceuticals Inc
Original Assignee
Endo Pharmaceuticals, Inc.
Michael Goldberg
Bradley Stuart Galer
Huai-Hung Kao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endo Pharmaceuticals, Inc., Michael Goldberg, Bradley Stuart Galer, Huai-Hung Kao filed Critical Endo Pharmaceuticals, Inc.
Publication of CA2447807A1 publication Critical patent/CA2447807A1/en
Application granted granted Critical
Publication of CA2447807C publication Critical patent/CA2447807C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A pharmaceutical composition intended for oral use contains the effective ingredient(s), capsaicin, and other typical fillers and excipients. The composition is preferably in the form of a solid oral dosage form.
Transdermally administered compositions are also within the purview of the invention. Aside from the effective pharmaceutical ingredient(s) the composition includes an amount of capsaicin which serves as a deterrent to the intranasal, intravenous, or oral abuse of the composition. Such a composition deters abusers from crushing prescription pharmaceutical tablets for abusive snorting, injection, or ingestion.
CA002447807A 2001-05-23 2002-05-16 Abuse resistant pharmaceutical composition containing capsaicin Expired - Fee Related CA2447807C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29280901P 2001-05-23 2001-05-23
US60/292,809 2001-05-23
PCT/US2002/015553 WO2002094254A2 (en) 2001-05-23 2002-05-16 Abuse resistant pharmaceutical composition containing capsaicin

Publications (2)

Publication Number Publication Date
CA2447807A1 true CA2447807A1 (en) 2002-11-28
CA2447807C CA2447807C (en) 2009-10-13

Family

ID=23126288

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002447807A Expired - Fee Related CA2447807C (en) 2001-05-23 2002-05-16 Abuse resistant pharmaceutical composition containing capsaicin

Country Status (10)

Country Link
US (1) US20030064122A1 (en)
EP (1) EP1392270B1 (en)
JP (2) JP4315687B2 (en)
CN (1) CN1511030A (en)
AT (1) ATE423556T1 (en)
AU (1) AU2002309885B2 (en)
CA (1) CA2447807C (en)
DE (1) DE60231298D1 (en)
ES (1) ES2321589T3 (en)
WO (1) WO2002094254A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9763886B2 (en) 2006-08-25 2017-09-19 Purdue Pharma L.P. Tamper resistant dosage forms

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Cited By (17)

* Cited by examiner, † Cited by third party
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US9763886B2 (en) 2006-08-25 2017-09-19 Purdue Pharma L.P. Tamper resistant dosage forms
US9763933B2 (en) 2006-08-25 2017-09-19 Purdue Pharma L.P. Tamper resistant dosage forms
US9770416B2 (en) 2006-08-25 2017-09-26 Purdue Pharma L.P. Tamper resistant dosage forms
US9770417B2 (en) 2006-08-25 2017-09-26 Purdue Pharma L.P. Tamper resistant dosage forms
US9775810B2 (en) 2006-08-25 2017-10-03 Purdue Pharma L.P. Tamper resistant dosage forms
US9775812B2 (en) 2006-08-25 2017-10-03 Purdue Pharma L.P. Tamper resistant dosage forms
US9775809B2 (en) 2006-08-25 2017-10-03 Purdue Pharma L.P. Tamper resistant dosage forms
US9775808B2 (en) 2006-08-25 2017-10-03 Purdue Pharma L.P. Tamper resistant dosage forms
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US10076499B2 (en) 2006-08-25 2018-09-18 Purdue Pharma L.P. Tamper resistant dosage forms
US10076498B2 (en) 2006-08-25 2018-09-18 Purdue Pharma L.P. Tamper resistant dosage forms
US11298322B2 (en) 2006-08-25 2022-04-12 Purdue Pharma L.P. Tamper resistant dosage forms
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US11904055B2 (en) 2006-08-25 2024-02-20 Purdue Pharma L.P. Tamper resistant dosage forms
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Also Published As

Publication number Publication date
ATE423556T1 (en) 2009-03-15
CA2447807C (en) 2009-10-13
CN1511030A (en) 2004-07-07
WO2002094254A2 (en) 2002-11-28
JP4315687B2 (en) 2009-08-19
WO2002094254A3 (en) 2003-03-27
EP1392270A2 (en) 2004-03-03
JP2009149696A (en) 2009-07-09
ES2321589T3 (en) 2009-06-09
JP2005515153A (en) 2005-05-26
US20030064122A1 (en) 2003-04-03
EP1392270B1 (en) 2009-02-25
DE60231298D1 (en) 2009-04-09
AU2002309885B2 (en) 2007-11-01

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