CA2320878A1 - Microgranules de sulfate de morphine, procede de fabrication et preparations pharmaceutiques - Google Patents

Microgranules de sulfate de morphine, procede de fabrication et preparations pharmaceutiques Download PDF

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Publication number
CA2320878A1
CA2320878A1 CA002320878A CA2320878A CA2320878A1 CA 2320878 A1 CA2320878 A1 CA 2320878A1 CA 002320878 A CA002320878 A CA 002320878A CA 2320878 A CA2320878 A CA 2320878A CA 2320878 A1 CA2320878 A1 CA 2320878A1
Authority
CA
Canada
Prior art keywords
microgranules
pharmaceutical preparations
making same
present
morphine sulfate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002320878A
Other languages
English (en)
Other versions
CA2320878C (fr
Inventor
Patrice Debregeas
Gerard Leduc
Pascal Oury
Pascal Suplie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethypharm SAS
Original Assignee
Laboratoires Des Produits Ethiques Ethypharm
Patrice Debregeas
Gerard Leduc
Pascal Oury
Pascal Suplie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Des Produits Ethiques Ethypharm, Patrice Debregeas, Gerard Leduc, Pascal Oury, Pascal Suplie filed Critical Laboratoires Des Produits Ethiques Ethypharm
Publication of CA2320878A1 publication Critical patent/CA2320878A1/fr
Application granted granted Critical
Publication of CA2320878C publication Critical patent/CA2320878C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Abstract

La présente invention concerne une nouvelle formulation orale à libération immédiate de sulfate de morphine sous forme de microgranules. Chaque microgranule comprend un grain support neutre enrobé d'un mélange de sulfate de morphine et d'un liant comme l'hydroxypropylméthylcellulose, qui représente 10 à 50 % en poids du mélange sulfate de morphine/liant. La présente invention concerne également un procédé de préparation de ces microgranules entièrement réalisé en milieu aqueux sur des grains supports neutres. La présente invention concerne enfin les préparations pharmaceutiques contenant les microgranules selon l'invention.
CA002320878A 1998-02-16 1999-02-15 Microgranules de sulfate de morphine, procede de fabrication et preparations pharmaceutiques Expired - Lifetime CA2320878C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR98/01816 1998-02-16
FR9801816A FR2774910B1 (fr) 1998-02-16 1998-02-16 Microgranules de sulfate de morphine, procede de fabrication et preparations pharmaceutiques
PCT/FR1999/000326 WO1999040918A1 (fr) 1998-02-16 1999-02-15 Microgranules de sulfate de morphine, procede de fabrication et preparations pharmaceutiques

Publications (2)

Publication Number Publication Date
CA2320878A1 true CA2320878A1 (fr) 1999-08-19
CA2320878C CA2320878C (fr) 2009-04-21

Family

ID=9522990

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002320878A Expired - Lifetime CA2320878C (fr) 1998-02-16 1999-02-15 Microgranules de sulfate de morphine, procede de fabrication et preparations pharmaceutiques

Country Status (16)

Country Link
US (2) US6482437B2 (fr)
EP (1) EP1054672B1 (fr)
JP (1) JP4447166B2 (fr)
CN (1) CN1135981C (fr)
AU (1) AU2429899A (fr)
BR (1) BR9907908A (fr)
CA (1) CA2320878C (fr)
CY (1) CY1107559T1 (fr)
DE (1) DE69934781T2 (fr)
DK (1) DK1054672T3 (fr)
ES (1) ES2277427T3 (fr)
FR (1) FR2774910B1 (fr)
HK (1) HK1036402A1 (fr)
NZ (1) NZ506307A (fr)
PT (1) PT1054672E (fr)
WO (1) WO1999040918A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790668B1 (fr) * 1999-03-12 2002-07-26 D B F Granules contenant une substance vegetale et leur procede de preparation
US20040253310A1 (en) 2001-09-21 2004-12-16 Gina Fischer Morphine polymer release system
US20040234602A1 (en) 2001-09-21 2004-11-25 Gina Fischer Polymer release system
ES2360102T3 (es) 2003-03-26 2011-05-31 Egalet A/S Sistema para la liberación controlada de morfina.
BRPI0415242B8 (pt) * 2003-10-10 2021-05-25 Ethypharm Sa microgrânulos de liberação gradual contendo extrato de gingko biloba e o processo para fabricar estes
FR2883179B1 (fr) 2005-03-18 2009-04-17 Ethypharm Sa Comprime enrobe
US20070190141A1 (en) * 2006-02-16 2007-08-16 Aaron Dely Extended release opiate composition
US20070286900A1 (en) * 2006-06-09 2007-12-13 Catherine Herry Low dose tablets of opioid analgesics and preparation process
US20100233257A1 (en) * 2006-06-09 2010-09-16 Ethypharm Low dose sublingual tablets of opioid analgesics and preparation process
AU2008258596B2 (en) 2007-06-04 2013-02-14 Egalet Ltd Controlled release pharmaceutical compositions for prolonged effect
KR101545874B1 (ko) * 2007-09-03 2015-08-20 나노테라퓨틱스, 인코포레이티드 난용성 약물의 전달을 위한 입상 조성물
NZ594207A (en) 2009-02-06 2013-03-28 Egalet Ltd Immediate release composition resistant to abuse by intake of alcohol
EP2445487A2 (fr) 2009-06-24 2012-05-02 Egalet Ltd. Formulations à libération contrôlée
EP2877161A1 (fr) 2012-07-06 2015-06-03 Egalet Ltd. Compositions pharmaceutiques de dissuasion d'abus à libération contrôlée
US9683448B2 (en) 2013-03-18 2017-06-20 Honeywell International Inc. Low conductivity thermal barrier coating
US11479846B2 (en) 2014-01-07 2022-10-25 Honeywell International Inc. Thermal barrier coatings for turbine engine components

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4096238A (en) * 1974-12-23 1978-06-20 Alza Corporation Method for administering drug to the gastrointestinal tract
US4309996A (en) * 1980-04-28 1982-01-12 Alza Corporation System with microporous releasing diffusor
US4673405A (en) * 1983-03-04 1987-06-16 Alza Corporation Osmotic system with instant drug availability
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
DE3708856A1 (de) 1987-03-18 1988-09-29 Kajetan Leitner Mit zaehnen versehene einpressmutter
US5202128A (en) * 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5891471A (en) * 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
US5411745A (en) * 1994-05-25 1995-05-02 Euro-Celtique, S.A. Powder-layered morphine sulfate formulations
US5582838A (en) * 1994-12-22 1996-12-10 Merck & Co., Inc. Controlled release drug suspension delivery device
US6066339A (en) * 1997-10-17 2000-05-23 Elan Corporation, Plc Oral morphine multiparticulate formulation

Also Published As

Publication number Publication date
AU2429899A (en) 1999-08-30
EP1054672B1 (fr) 2007-01-10
CN1135981C (zh) 2004-01-28
DE69934781D1 (de) 2007-02-22
US20020028246A1 (en) 2002-03-07
PT1054672E (pt) 2007-04-30
JP2002502877A (ja) 2002-01-29
DK1054672T3 (da) 2007-04-10
DE69934781T2 (de) 2007-10-11
FR2774910B1 (fr) 2001-09-07
US20030129244A1 (en) 2003-07-10
US6482437B2 (en) 2002-11-19
CN1291097A (zh) 2001-04-11
HK1036402A1 (en) 2002-01-04
EP1054672A1 (fr) 2000-11-29
NZ506307A (en) 2003-11-28
CA2320878C (fr) 2009-04-21
BR9907908A (pt) 2002-04-30
FR2774910A1 (fr) 1999-08-20
JP4447166B2 (ja) 2010-04-07
WO1999040918A1 (fr) 1999-08-19
ES2277427T3 (es) 2007-07-01
CY1107559T1 (el) 2013-03-13

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Effective date: 20190215