CA2136411A1 - Immediate Release Tablet Cores of Insoluble Drugs Having Sustained Release Coating - Google Patents

Immediate Release Tablet Cores of Insoluble Drugs Having Sustained Release Coating

Info

Publication number
CA2136411A1
CA2136411A1 CA2136411A CA2136411A CA2136411A1 CA 2136411 A1 CA2136411 A1 CA 2136411A1 CA 2136411 A CA2136411 A CA 2136411A CA 2136411 A CA2136411 A CA 2136411A CA 2136411 A1 CA2136411 A1 CA 2136411A1
Authority
CA
Canada
Prior art keywords
tablet
active agent
tablet cores
therapeutically active
insoluble drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2136411A
Other languages
French (fr)
Other versions
CA2136411C (en
Inventor
Benjamin Oshlack
Mark Chasin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Benjamin Oshlack
Mark Chasin
Euro-Celtique, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Benjamin Oshlack, Mark Chasin, Euro-Celtique, S.A. filed Critical Benjamin Oshlack
Publication of CA2136411A1 publication Critical patent/CA2136411A1/en
Application granted granted Critical
Publication of CA2136411C publication Critical patent/CA2136411C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide

Abstract

A controlled release tablet for oral administration is disclosed which has a tablet core including an insoluble therapeutically active agent having an aqueous solubility of less than or equal to about 5 mg/ml in a sufficient amount to render a therapeutic effect. The core provides rapid release of said therapeutically active agent upon exposure to aqueous solutions. The tablet core is coated with a controlled release coating permitting sustained release of said therapeutically active agent when said coated tablet is exposed to aqueous solutions.
CA002136411A 1993-11-23 1994-11-22 Immediate release tablet cores of insoluble drugs having sustained release coating Expired - Fee Related CA2136411C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US156,460 1993-11-23
US08/156,460 US5500227A (en) 1993-11-23 1993-11-23 Immediate release tablet cores of insoluble drugs having sustained-release coating
CNB94118420XA CN1247190C (en) 1993-11-23 1994-11-23 Immediate release tablet cores of insoluble drugs having sustained release coating

Publications (2)

Publication Number Publication Date
CA2136411A1 true CA2136411A1 (en) 1995-05-24
CA2136411C CA2136411C (en) 2000-05-02

Family

ID=36954597

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002136411A Expired - Fee Related CA2136411C (en) 1993-11-23 1994-11-22 Immediate release tablet cores of insoluble drugs having sustained release coating

Country Status (16)

Country Link
US (2) US5500227A (en)
EP (1) EP0655240B1 (en)
JP (1) JPH07252140A (en)
KR (1) KR100220163B1 (en)
CN (1) CN1247190C (en)
AT (1) ATE202473T1 (en)
CA (1) CA2136411C (en)
DE (1) DE69427568T2 (en)
ES (1) ES2157944T3 (en)
FI (1) FI115824B (en)
HU (1) HU227381B1 (en)
IL (2) IL111519A (en)
NO (1) NO314711B1 (en)
PT (1) PT655240E (en)
TW (2) TW577757B (en)
ZA (1) ZA948677B (en)

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